Dhea supplements and hypertension or

[Rabbit91476]

Can dhea supplementation cause hypertension. I started 25 mg/day about three weeks ago. No I don’t have labs yet. Yes I know blood pressure increase can be multifaceted. Three days ago I drank to much I I assumed it was that. But it’s been 36 hours with out alcohol and my blood pressure is averaging 15 pts higher than normal. Sup now 148-1160. . And I’m just curious is the dhea could be playing a small role

 

[BigTex]

I have heard of a few anecdotal reports of increases but it appears this meta-analysis of randomized clinical trialsl found the opposite. Might be a good idea to stop taking it and see if your blood pressure returns to normal.

Wang F, He Y, O Santos H, Sathian B, C Price J, Diao J. The effects of dehydroepiandrosterone (DHEA) supplementation on body composition and blood pressure: A meta-analysis of randomized clinical trials. Steroids. 2020 Nov;163:108710. doi: 10.1016/j.steroids.2020.108710. Epub 2020 Jul 31. PMID: 32745490.

Abstract​

Dehydroepiandrosterone (DHEA) supplementation has been anecdotally considered as a tool to improve body composition and health status. We aimed to verify the impact of DHEA supplementation on traditional measurements of body composition and blood pressure (BP) due to their clinical applicability. A meta-analysis of randomized clinical trials was conducted based on the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. Regarding anthropometric characteristics, DHEA supplementation did not change body weight (weighted mean difference (WMD): -0.16 kg, 95% CI: -1.02 to 0.70, p = 0.72) or body mass index (WMD: -0.18 kg/m2, 95% CI: -0.48 to 0.12, p = 0.24), but increased lean body mass (WMD: 0.45 kg, 95% CI: 0.15 to 0.75, p = 0.004) and decreased fat mass (WMD: -0.85%, 95% CI: -1.18 to -0.51, p = 0.000), when compared to control groups. Neither systolic (WMD: 0.98 mm Hg, 95% CI: -2.31 to 4.29, p = 0.56) nor diastolic BP were significantly changed (WMD: -1.62 mm Hg, 95% CI: -5.49 to 2.24, p = 0.49). Our findings demonstrate that DHEA supplementation increased lean body mass and decreased fat mass, but debate persists when translating the results into clinical benefit. Lastly, DHEA supplementation had a neutral effect on BP.

 

[Willyt]

DHEA seems to cause more problems to forum members than it solves. I've never understood why its so popular in TRT world

 

[Rabbit91476]

DHEA seems to cause more problems to forum members than it solves. I've never understood why its so popular in TRT world

Like what other problems

 

[Willyt]

Like what other problems

Agitation, headache, anxiety, high E2. Look at some of the DHEA threads on here and you will find plenty. Then again, some guys swear by it. Definitely did not agree with my body.

 

[BigTex]

I think the problem with DHEA is levels peak between ages 20 and 30, then decline at a rate of roughly 5% every year as we grow older. Seems having low DHEA levels is where the problems start. Probably a good idea to find out what your DHEA-S levels are before making the decision to use DHEA supplements or not. Having levels towards the high end of normal are probably not a bad idea.

 

[Rabbit91476]

Not that I think about it. My average weight is up about three pounds in the last week

 

[D0UG]

My hormone doctor recommended DHEA and said to take it at night. I wonder when others take it.

 

[Shawn]

are you still using DHEA? did the hypertension resolve on its own? i believe this is a side effect of either DHT -> CNS stimulation or estrogen -> edema.