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General Health & Fitness
Nutrition and Supplements
DHEA dose, blood levels, half life, estrogen
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<blockquote data-quote="Cataceous" data-source="post: 171315" data-attributes="member: 38109"><p>Regarding variations in serum DHEA-S levels, for me the dose-response relationship with DHEA supplementation is very consistent. Mostly I take 12.5 mg a day, which keeps DHEA-S at 260-300 ug/dL.</p><p></p><p>Wikipedia says the half-life of DHEA-S is 7-10 hours. This suggests that serum levels stabilize in under two days.</p><p></p><p>In younger men with functional HPTAs it's pretty unambiguous that DHEA supplementation does not raise estradiol, even at enormous doses, like 400 mg/d. I think Nelson found a study suggesting a measurable effect in older guys, but it wasn't large, maybe 10% if I'm remembering correctly. In general it doesn't make sense that DHEA is going to increase E2 because this would greatly suppress testosterone production, which is not seen. The situation is less clear when TRT is involved, as then there's not the same type of regulation. Even so, all we have in these cases are scattered anecdotal reports of effects or no effects.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 171315, member: 38109"] Regarding variations in serum DHEA-S levels, for me the dose-response relationship with DHEA supplementation is very consistent. Mostly I take 12.5 mg a day, which keeps DHEA-S at 260-300 ug/dL. Wikipedia says the half-life of DHEA-S is 7-10 hours. This suggests that serum levels stabilize in under two days. In younger men with functional HPTAs it's pretty unambiguous that DHEA supplementation does not raise estradiol, even at enormous doses, like 400 mg/d. I think Nelson found a study suggesting a measurable effect in older guys, but it wasn't large, maybe 10% if I'm remembering correctly. In general it doesn't make sense that DHEA is going to increase E2 because this would greatly suppress testosterone production, which is not seen. The situation is less clear when TRT is involved, as then there's not the same type of regulation. Even so, all we have in these cases are scattered anecdotal reports of effects or no effects. [/QUOTE]
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General Health & Fitness
Nutrition and Supplements
DHEA dose, blood levels, half life, estrogen
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