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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
DESSICATED THYROID CONTINUES HAVING ZERO EFFECT ON TSH; ELEVATED FT3, NORMAL FT4
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<blockquote data-quote="mcs" data-source="post: 211724" data-attributes="member: 12"><p>My last labs were done 24h after my last dose as I posted in this <a href="https://app.box.com/file/822535801925?s=3jlf4hf6n2ht1cek36msmkot6xo9ttn1" target="_blank">historical chart</a> (see 09/07/21 date). I periodically run labs soon after taking my dose to check how well it's working.</p><p></p><p>I'm now wondering if it's a problem with my pituitary/hypothalamus. Like a bad thermostat, I keep "adjusting the dial" (i.e. adding T3/T4) but the temperature (i.e. TSH) stays the same.</p><p></p><p>A <a href="https://app.box.com/s/fztcybgpjzmwll9z9lzpvjtvy1wsff26" target="_blank">partially-empty sella</a> was found in my sella turcica as an incidental discovery on a brain MRI some years ago. I have mentioned this finding to just about every practitioner I can think of and the answer was always the same: you would know if you had <a href="https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3990803/" target="_blank">ESS</a> (empty sella syndrome) because most or all of your hormone levels would be out of range.</p><p></p><p>Maybe I should look into getting a TRH (Thyrotropin-releasing hormone, what the hypothalamus releases to get the pituitary to release TRH) drawn and see if it is unusually high.</p><p></p><p>If the TRH is good then it may be a "stuck" pituitary (i.e. hypothalamus properly senses T3/T4 but pituitary keeps pumping out TSH). If the TRH is unusually high it may signal that the hypothalamus is the issue. Despite proper levels of T3/T4 it continues to release too much TRH.</p><p></p><p>It may therefore be an exercise in futility, but to rule it out, neither Quest nor LabCorp offer TRH since it’s a <a href="https://www.verywellhealth.com/trh-stimulation-test-thyroid-testing-3232910" target="_blank">stim test</a>, so definitely haven’t had that done. Needs to be performed in a doc’s clinic or hospital. May also be a challenge to get the endo to do it since I have no other signs or sxs of ESS.</p><p></p><p>At the end of the day though, the treatment for that is usually T4 as indicated in <a href="https://link.springer.com/article/10.1007/BF03349796" target="_blank">this study</a>. Re-trialing T4 was on my above list of possible actions to take anyways, so maybe give it a shot again to see if it corrects? My guess is that's what any endo would advise before subjecting myself to a TRH stim test.</p></blockquote><p></p>
[QUOTE="mcs, post: 211724, member: 12"] My last labs were done 24h after my last dose as I posted in this [URL='https://app.box.com/file/822535801925?s=3jlf4hf6n2ht1cek36msmkot6xo9ttn1']historical chart[/URL] (see 09/07/21 date). I periodically run labs soon after taking my dose to check how well it's working. I'm now wondering if it's a problem with my pituitary/hypothalamus. Like a bad thermostat, I keep "adjusting the dial" (i.e. adding T3/T4) but the temperature (i.e. TSH) stays the same. A [URL='https://app.box.com/s/fztcybgpjzmwll9z9lzpvjtvy1wsff26']partially-empty sella[/URL] was found in my sella turcica as an incidental discovery on a brain MRI some years ago. I have mentioned this finding to just about every practitioner I can think of and the answer was always the same: you would know if you had [URL='https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3990803/']ESS[/URL] (empty sella syndrome) because most or all of your hormone levels would be out of range. Maybe I should look into getting a TRH (Thyrotropin-releasing hormone, what the hypothalamus releases to get the pituitary to release TRH) drawn and see if it is unusually high. If the TRH is good then it may be a "stuck" pituitary (i.e. hypothalamus properly senses T3/T4 but pituitary keeps pumping out TSH). If the TRH is unusually high it may signal that the hypothalamus is the issue. Despite proper levels of T3/T4 it continues to release too much TRH. It may therefore be an exercise in futility, but to rule it out, neither Quest nor LabCorp offer TRH since it’s a [URL='https://www.verywellhealth.com/trh-stimulation-test-thyroid-testing-3232910']stim test[/URL], so definitely haven’t had that done. Needs to be performed in a doc’s clinic or hospital. May also be a challenge to get the endo to do it since I have no other signs or sxs of ESS. At the end of the day though, the treatment for that is usually T4 as indicated in [URL='https://link.springer.com/article/10.1007/BF03349796']this study[/URL]. Re-trialing T4 was on my above list of possible actions to take anyways, so maybe give it a shot again to see if it corrects? My guess is that's what any endo would advise before subjecting myself to a TRH stim test. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
DESSICATED THYROID CONTINUES HAVING ZERO EFFECT ON TSH; ELEVATED FT3, NORMAL FT4
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