Coronavirus COVID-19 Update: Hydroxychloroquine and Other Treatments

[Rock H. Johnson]

Covid-19 had us all fooled, but now we might have finally found its secret.

In the last 3–5 days, a mountain of anecdotal evidence has come out of NYC, Italy, Spain, etc. about COVID-19 and characteristics of…

web.archive.org

 

[Rock H. Johnson]

So far the PM is getting oxygen but not on require a ventilator. At least not yet.

I don't think there are any good treatments, but I would try blood with antibodies as the most likely helpful.

Any treatment that had any kind of good success we would already know about since the USA is the world leader in cases of covid and there are plenty of opps to try a treatment.

They did not put him on a ventilator as it is the wrong way of treatment....the ventilators are doing more harm then good. They already knew that in Europe from the experiences in Spain and Italy.

 

[MarkLA]

"We focused on fourteen phenolic compounds grouped according to their chemical structure, including the flavonoids quercetin (QCT), epigallocatechin-3-gallate (EGCG)(FROM GREEN TEA), luteolin (LUT), narin- genin (NAR), phloretin (PHLO), genistein (GEN), catechin hydrate (CAT HYD), rutin (RUT) and dihydroquercetin or taxifolin (TAX); the phenolic acids gallic acid (GAL), tannic acid (TAN) and caffeic acid (CAF); the stilbene resveratrol (RSV); and other polyphenols such as catechol (CAT). Two different zinc ionophore agents, clioquinol and pyrithione, were used to compare the ionophore activity of the selected polyphenols"

Any thoughts on how to dose EGCG/QCT + Zinc in humans if one needed to use them therapeutically?

 

[DragonBits]

They did not put him on a ventilator as it is the wrong way of treatment....the ventilators are doing more harm then good. They already knew that in Europe from the experiences in Spain and Italy.

When they put someone on a ventilator, it's because they cannot breathe even with oxygen, choice is death or ventilator.

There is the ECMO treatment, which does sound better to me.

But not sure how you do more harm than death.

 

[Rock H. Johnson]

When they put someone on a ventilator, it's because they cannot breathe even with oxygen, choice is death or ventilator.

Not sure how you do more harm than death.

Short version:
They can physically breath but because they can not absorb the oxygen into the alveoli as there is no iron to bind to as the blood is desaturated.... the ventilators do not help the lungs as this destroys the tissue.

Long version:
Your red blood cells carry oxygen from your lungs to all your organs and the rest of your body. Red blood cells can do this thanks to hemoglobin, which is a protein consisting of four “hemes”. Hemes have a special kind of iron ion, which is normally quite toxic in its free form, locked away in its center with a porphyrin acting as it’s ‘container’. In this way, the iron ion can be ‘caged’ and carried around safely by the hemoglobin, but used to bind to oxygen when it gets to your lungs.

When the red blood cell gets to the alveoli, or the little sacs in your lungs where all the gas exchange happens, that special little iron ion can flip between FE2+ and FE3+ states with electron exchange and bond to some oxygen, then it goes off on its little merry way to deliver o2 elsewhere.

Here’s where COVID-19 comes in. Its glycoproteins bond to the heme, and in doing so that special and toxic oxidative iron ion is “disassociated” (released). It’s basically let out of the cage and now freely roaming around on its own. This is bad for two reasons:

1) Without the iron ion, hemoglobin can no longer bind to oxygen. Once all the hemoglobin is impaired, the red blood cell is essentially turned into a Freightliner truck cab with no trailer and no ability to store its cargo.. it is useless and just running around with COVID-19 virus attached to its porphyrin. All these useless trucks running around not delivering oxygen is what starts to lead to desaturation, or watching the patient’s spo2 levels drop. It is INCORRECT to assume traditional ARDS and in doing so, you’re treating the WRONG DISEASE. Think of it a lot like carbon monoxide poisoning, in which CO is bound to the hemoglobin, making it unable to carry oxygen. In those cases, ventilators aren’t treating the root cause; the patient’s lungs aren’t ‘tiring out’, they’re pumping just fine. The red blood cells just can’t carry o2, end of story. Only in this case, unlike CO poisoning in which eventually the CO can break off, the affected hemoglobin is permanently stripped of its ability to carry o2 because it has lost its iron ion. The body compensates for this lack of o2 carrying capacity and deliveries by having your kidneys release hormones like erythropoietin, which tell your bone marrow factories to ramp up production on new red blood cells with freshly made and fully functioning hemoglobin. This is the reason you find elevated hemoglobin and decreased blood oxygen saturation as one of the 3 primary indicators of whether the shit is about to hit the fan for a particular patient or not.

2) That little iron ion, along with millions of its friends released from other hemes, are now floating through your blood freely. As I mentioned before, this type of iron ion is highly reactive and causes oxidative damage. It turns out that this happens to a limited extent naturally in our bodies and we have cleanup & defense mechanisms to keep the balance. The lungs, in particular, have 3 primary defenses to maintain “iron homeostasis”, 2 of which are in the alveoli, those little sacs in your lungs we talked about earlier. The first of the two are little macrophages that roam around and scavenge up any free radicals like this oxidative iron. The second is a lining on the walls (called the epithelial surface) which has a thin layer of fluid packed with high levels of antioxidant molecules.. things like abscorbic acid (AKA Vitamin C) among others. Well, this is usually good enough for naturally occurring rogue iron ions but with COVID-19 running rampant your body is now basically like a progressive state letting out all the prisoners out of the prisons… it’s just too much iron and it begins to overwhelm your lungs’ countermeasures, and thus begins the process of pulmonary oxidative stress. This leads to damage and inflammation, which leads to all that nasty stuff and damage you see in CT scans of COVID-19 patient lungs. Ever noticed how it’s always bilateral? (both lungs at the same time) Pneumonia rarely ever does that, but COVID-19 does… EVERY. SINGLE. TIME.

 

[GreenMachineX]

View attachment 9479

"We focused on fourteen phenolic compounds grouped according to their chemical structure, including the flavonoids quercetin (QCT), epigallocatechin-3-gallate (EGCG)(FROM GREEN TEA), luteolin (LUT), narin- genin (NAR), phloretin (PHLO), genistein (GEN), catechin hydrate (CAT HYD), rutin (RUT) and dihydroquercetin or taxifolin (TAX); the phenolic acids gallic acid (GAL), tannic acid (TAN) and caffeic acid (CAF); the stilbene resveratrol (RSV); and other polyphenols such as catechol (CAT). Two different zinc ionophore agents, clioquinol and pyrithione, were used to compare the ionophore activity of the selected polyphenols"

Do you interpret that as quercetin and EGCG as being valuable?

 

[GreenMachineX]

Any thoughts on how to dose EGCG/QCT + Zinc in humans if one needed to use them therapeutically?

Good question.

 

[Nelson Vergel]

Good question.

I am taking them for the last month after I saw some non COVID-19 data.

 

[Nelson Vergel]

When we have the antibody test available. It got approved two weeks ago. Here is how antibodies develop. The question is how long IgG will last.

Cellex Receives First FDA Emergency Use Authorization for Coronavirus Serology Test
Apr 02, 2020

NEW YORK – On Wednesday, Cellex became the first firm to receive Emergency Use Authorization from the US Food and Drug Administration for a coronavirus serology test. The assay, which resembles a pregnancy test, is authorized for use in laboratories certified under CLIA to perform as moderate- and highly-complexity tests.

Called the qSARS-CoV-2 IgG/IgM Rapid Test, the Cellex test is a lateral flow immunoassay to detect IgG and IgM in blood serum, plasma, or venipuncture whole blood specimens from patients suspected by a healthcare provider of COVID-19 infection. Results can be read from the test device after approximately 15 minutes according to the instructions for use, and labs must report positive results to public health authorities.

The levels of IgM in a patient's blood begin to rise to detectable levels a few days after infection, while IgG levels become elevated later. Positive results for both IgG and IgM could occur after infection and be indicative of acute or recent infection.

The FDA has guided in its "Policy D" that serology tests that are not intended for sole diagnosis do not need only to notify the agency prior to marketing in the US and do not need to come through the EUA process. However, it has also guided that manufacturers claiming a test can be used as a sole diagnostic should come submit an EUA.

The test's clinical validation, as noted in the IFU, involved 98 positive serum or plasma samples collected from individuals who tested positive with a RT- PCR method for SARS-CoV-2 infection who exhibited mild or no clinical symptoms and 180 negative serum or plasma samples collected prior to September 2019.

Of the 98 positive samples, 91 were positive with IgG or IgM or both. Of the 180 negative samples, 174 were negative.

Another 30 samples were collected from hospitalized individuals who were clinically confirmed positive for SARSCoV-2 infection and exhibited severe symptoms. These samples, along with 70 negative serum or plasma samples, were tested with the qSARS-CoV-2 IgG/IgM Rapid Test. Of the 30 positive samples, 29 were positive with IgG or IgM or both. Of the 70 negative samples, 65 were negative.

Taken together, the qSARS-CoV-2 IgG/IgM Rapid Test had a 94 percent positive percent agreement and 96 percent negative percent agreement.

 

[DragonBits]

Short version:
They can physically breath but because they can not absorb the oxygen into the alveoli as there is no iron to bind to as the blood is desaturated.... the ventilators do not help the lungs as this destroys the tissue.

Long version:
Your red blood cells carry oxygen from your lungs to all your organs and the rest of your body. Red blood cells can do this thanks to hemoglobin, which is a protein consisting of four “hemes”. Hemes have a special kind of iron ion, which is normally quite toxic in its free form, locked away in its center with a porphyrin acting as it’s ‘container’. In this way, the iron ion can be ‘caged’ and carried around safely by the hemoglobin, but used to bind to oxygen when it gets to your lungs.

When the red blood cell gets to the alveoli, or the little sacs in your lungs where all the gas exchange happens, that special little iron ion can flip between FE2+ and FE3+ states with electron exchange and bond to some oxygen, then it goes off on its little merry way to deliver o2 elsewhere.

Here’s where COVID-19 comes in. Its glycoproteins bond to the heme, and in doing so that special and toxic oxidative iron ion is “disassociated” (released). It’s basically let out of the cage and now freely roaming around on its own. This is bad for two reasons:

1) Without the iron ion, hemoglobin can no longer bind to oxygen. Once all the hemoglobin is impaired, the red blood cell is essentially turned into a Freightliner truck cab with no trailer and no ability to store its cargo.. it is useless and just running around with COVID-19 virus attached to its porphyrin. All these useless trucks running around not delivering oxygen is what starts to lead to desaturation, or watching the patient’s spo2 levels drop. It is INCORRECT to assume traditional ARDS and in doing so, you’re treating the WRONG DISEASE. Think of it a lot like carbon monoxide poisoning, in which CO is bound to the hemoglobin, making it unable to carry oxygen. In those cases, ventilators aren’t treating the root cause; the patient’s lungs aren’t ‘tiring out’, they’re pumping just fine. The red blood cells just can’t carry o2, end of story. Only in this case, unlike CO poisoning in which eventually the CO can break off, the affected hemoglobin is permanently stripped of its ability to carry o2 because it has lost its iron ion. The body compensates for this lack of o2 carrying capacity and deliveries by having your kidneys release hormones like erythropoietin, which tell your bone marrow factories to ramp up production on new red blood cells with freshly made and fully functioning hemoglobin. This is the reason you find elevated hemoglobin and decreased blood oxygen saturation as one of the 3 primary indicators of whether the shit is about to hit the fan for a particular patient or not.

2) That little iron ion, along with millions of its friends released from other hemes, are now floating through your blood freely. As I mentioned before, this type of iron ion is highly reactive and causes oxidative damage. It turns out that this happens to a limited extent naturally in our bodies and we have cleanup & defense mechanisms to keep the balance. The lungs, in particular, have 3 primary defenses to maintain “iron homeostasis”, 2 of which are in the alveoli, those little sacs in your lungs we talked about earlier. The first of the two are little macrophages that roam around and scavenge up any free radicals like this oxidative iron. The second is a lining on the walls (called the epithelial surface) which has a thin layer of fluid packed with high levels of antioxidant molecules.. things like abscorbic acid (AKA Vitamin C) among others. Well, this is usually good enough for naturally occurring rogue iron ions but with COVID-19 running rampant your body is now basically like a progressive state letting out all the prisoners out of the prisons… it’s just too much iron and it begins to overwhelm your lungs’ countermeasures, and thus begins the process of pulmonary oxidative stress. This leads to damage and inflammation, which leads to all that nasty stuff and damage you see in CT scans of COVID-19 patient lungs. Ever noticed how it’s always bilateral? (both lungs at the same time) Pneumonia rarely ever does that, but COVID-19 does… EVERY. SINGLE. TIME.

I am amused as your tag line on your profile.

"A wise man once said nothing"

 

[Nelson Vergel]

Short version:
They can physically breath but because they can not absorb the oxygen into the alveoli as there is no iron to bind to as the blood is desaturated.... the ventilators do not help the lungs as this destroys the tissue.

Long version:
Your red blood cells carry oxygen from your lungs to all your organs and the rest of your body. Red blood cells can do this thanks to hemoglobin, which is a protein consisting of four “hemes”. Hemes have a special kind of iron ion, which is normally quite toxic in its free form, locked away in its center with a porphyrin acting as it’s ‘container’. In this way, the iron ion can be ‘caged’ and carried around safely by the hemoglobin, but used to bind to oxygen when it gets to your lungs.

When the red blood cell gets to the alveoli, or the little sacs in your lungs where all the gas exchange happens, that special little iron ion can flip between FE2+ and FE3+ states with electron exchange and bond to some oxygen, then it goes off on its little merry way to deliver o2 elsewhere.

Here’s where COVID-19 comes in. Its glycoproteins bond to the heme, and in doing so that special and toxic oxidative iron ion is “disassociated” (released). It’s basically let out of the cage and now freely roaming around on its own. This is bad for two reasons:

1) Without the iron ion, hemoglobin can no longer bind to oxygen. Once all the hemoglobin is impaired, the red blood cell is essentially turned into a Freightliner truck cab with no trailer and no ability to store its cargo.. it is useless and just running around with COVID-19 virus attached to its porphyrin. All these useless trucks running around not delivering oxygen is what starts to lead to desaturation, or watching the patient’s spo2 levels drop. It is INCORRECT to assume traditional ARDS and in doing so, you’re treating the WRONG DISEASE. Think of it a lot like carbon monoxide poisoning, in which CO is bound to the hemoglobin, making it unable to carry oxygen. In those cases, ventilators aren’t treating the root cause; the patient’s lungs aren’t ‘tiring out’, they’re pumping just fine. The red blood cells just can’t carry o2, end of story. Only in this case, unlike CO poisoning in which eventually the CO can break off, the affected hemoglobin is permanently stripped of its ability to carry o2 because it has lost its iron ion. The body compensates for this lack of o2 carrying capacity and deliveries by having your kidneys release hormones like erythropoietin, which tell your bone marrow factories to ramp up production on new red blood cells with freshly made and fully functioning hemoglobin. This is the reason you find elevated hemoglobin and decreased blood oxygen saturation as one of the 3 primary indicators of whether the shit is about to hit the fan for a particular patient or not.

2) That little iron ion, along with millions of its friends released from other hemes, are now floating through your blood freely. As I mentioned before, this type of iron ion is highly reactive and causes oxidative damage. It turns out that this happens to a limited extent naturally in our bodies and we have cleanup & defense mechanisms to keep the balance. The lungs, in particular, have 3 primary defenses to maintain “iron homeostasis”, 2 of which are in the alveoli, those little sacs in your lungs we talked about earlier. The first of the two are little macrophages that roam around and scavenge up any free radicals like this oxidative iron. The second is a lining on the walls (called the epithelial surface) which has a thin layer of fluid packed with high levels of antioxidant molecules.. things like abscorbic acid (AKA Vitamin C) among others. Well, this is usually good enough for naturally occurring rogue iron ions but with COVID-19 running rampant your body is now basically like a progressive state letting out all the prisoners out of the prisons… it’s just too much iron and it begins to overwhelm your lungs’ countermeasures, and thus begins the process of pulmonary oxidative stress. This leads to damage and inflammation, which leads to all that nasty stuff and damage you see in CT scans of COVID-19 patient lungs. Ever noticed how it’s always bilateral? (both lungs at the same time) Pneumonia rarely ever does that, but COVID-19 does… EVERY. SINGLE. TIME.

You guys should watch this video. He debunks this

 

[Rock H. Johnson]

You guys should watch this video. He debunks this

He says at the end(16:00+), he has not seen it and this does not exclude the possibility that this is happening with other patients elsewhere. As with the ventilators, some have a form were they do more harm then good.

 

[GreenMachineX]

I am taking them for the last month after I saw some non COVID-19 data.

Would you mind sharing brand and dose of each?

 

[Westin]

Hydroxychloroquine rated ‘most effective therapy’ by doctors for coronavirus: Global survey

An international poll of more than 6,000 doctors released Thursday found that the antimalarial drug hydroxychloroquine was the most highly rated treatment for the novel coronavirus.

m.washingtontimes.com

An international poll of more than 6,000 doctors released Thursday found that the antimalarial drug hydroxychloroquine was the most highly rated treatment for the novel coronavirus.

The survey conducted by Sermo, a global health care polling company, of 6,227 physicians in 30 countries found that 37% of those treating COVID-19 patients rated hydroxychloroquine as the “most effective therapy” from a list of 15 options.

A poll is much different then a randomized double blind study, and that takes time. Until the data comes back it’s just a guess and hope. Not there is much wrong with that when you have nothing else. Don’t bank on anything until it has been proved. Everyone is touting something, but at this point we have nothing.

 

[Nelson Vergel]

Would you mind sharing brand and dose of each?

I bought these three two months ago when I first read about the virus and did some research on zinc ionophores.

Two per day (one dose)
Jarrow Formulas Quercetin, for Cardiovascular Support, 500mg, 200 Capsules


One per day (one dose)
Bluebonnet Nutrition Zinc Picolinate 50 mg Vegetable Capsules


One per day (morning time)
Green Tea 98% Extract with EGCG - 120 Capsules (Non-GMO) for Weight Loss & Metabolism Boost - Natural Diet Pills - Leaf Polyphenol Catechins

Of course, before someone says it, we have no data on this particular SARS-COV2 virus.

World-First Trial to Test Benefit of Intravenous Zinc in COVID-19 Fight

/PRNewswire/ -- A world-first trial will see researchers from Austin Health and the University of Melbourne use intravenous zinc to fight the symptoms of...

www.prnewswire.co.uk

Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

Quercetin inhibits rhinovirus replication in vitro and in vivo

Rhinovirus (RV), which is responsible for the majority of common colds, also causes exacerbations in patients with asthma and chronic obstructive pulm…

www.sciencedirect.com

Antiviral Mechanism of Action of Epigallocatechin-3-O-gallate and Its Fatty Acid Esters

Epigallocatechin-3-O-gallate (EGCG) is the major catechin component of green tea (Cameria sinensis), and is known to possess antiviral activities against a wide range of DNA viruses and RNA viruses. However, few studies have examined chemical modifications ...

www.ncbi.nlm.nih.gov

A simple liposome assay for the screening of zinc ionophore activity of polyphenols

An efficient liposomal system for screening the zinc ionophore activity of a selected library consisting of the most relevant dietary polyphenols is p…

www.sciencedirect.com

Zinc Ionophore Activity of Quercetin and Epigallocatechin-gallate

If you research around, quercetin seems to show broad spectrum antiviral activity across the board. It's most likely due to this zinc ionophore activity.

Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry

Effect of Quercetin on Hepatitis C Virus Life Cycle: From Viral to Host Targets

Antiviral activity of four types of bioflavonoid against dengue virus type-2


Dr. Paul Marik has an interesting protocol depending on the stage


COVID Care Protocol
Last Updated 04-07-2020 5:17 p.m.

The EVMS Medical Group is providing guidance for healthcare providers treating COVID-19 patients. This approach to COVID-19 is based on the best (and most recent) available literature and the Shanghai Management Guideline for COVID.

• Download the latest EVMS Critical Care COVID-19 Protocol developed by Dr. Paul Marik.
• Download the one-page Marik COVID-19 Protocol Summary.

This protocol often changes daily. Please bookmark and share evms.edu/covidcare to find the most up-to-date version of the guidelines.

 

[Nelson Vergel]

Join this national study if you don’t have symptoms. They do a phone interview and mail you a kit.

NIH begins study to quantify undetected cases of coronavirus infection

Blood samples from healthy volunteers needed to inform public health decision making.

www.nih.gov

Criteria

INCLUSION CRITERIA:

1. >= 18 years of age.
2. Willing and able to complete a verbal telephone consent.
3. Willing to undergo one blood draw or home blood sampling.
4. Willing to have blood samples stored for future research.

EXCLUSION CRITERIA:

1. Confirmed history of COVID19 infection or exposure
2. Current symptoms consistent with COVID19 infection
3. Any condition or event that, in the PI s opinion, may substantially increase the risk associated with study participation or compromise the study's scientific objectives. Conditions that exclude a subject are considered to be unlikely, but an example would include having an acute respiratory infection or recent exposure that would prevent participants that would make it unsafe to obtain blood samples.
4. Not willing to have blood samples stored for future research.

Participants will enroll and give consent over the phone. They will be screened over the phone with a health assessment questionnaire. They will be screened for COVID19 using the NIH COVID19 screening questionnaire.

Participants will give a blood sample. They can go to the NIH Clinical Center or do home blood sampling. In-person collection at NIH is preferred.

If participants go to NIH, 2 tubes of blood will be taken.

If participants do home sampling, they will be sent a home sampling kit. The kit contains gauze, an alcohol pad, a lancet, collection devices, and shipping materials. It also contains detailed instructions. They will collect 80ul of blood and mail it to the NIH lab.

Participants may enroll in the study up to 4 times. They cannot enroll within 30 days of previous enrollment.

 

[GreenMachineX]

I bought these three two months ago when I first read about the virus and did some research on zinc ionophores.

Two per day (one dose)
Jarrow Formulas Quercetin, for Cardiovascular Support, 500mg, 200 Capsules


One per day (one dose)
Bluebonnet Nutrition Zinc Picolinate 50 mg Vegetable Capsules


One per day (morning time)
Green Tea 98% Extract with EGCG - 120 Capsules (Non-GMO) for Weight Loss & Metabolism Boost - Natural Diet Pills - Leaf Polyphenol Catechins

Of course, before someone says it, we have no data on this particular SARS-COV2 virus.

World-First Trial to Test Benefit of Intravenous Zinc in COVID-19 Fight

/PRNewswire/ -- A world-first trial will see researchers from Austin Health and the University of Melbourne use intravenous zinc to fight the symptoms of...

www.prnewswire.co.uk

Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

Quercetin inhibits rhinovirus replication in vitro and in vivo

Rhinovirus (RV), which is responsible for the majority of common colds, also causes exacerbations in patients with asthma and chronic obstructive pulm…

www.sciencedirect.com

Antiviral Mechanism of Action of Epigallocatechin-3-O-gallate and Its Fatty Acid Esters

Epigallocatechin-3-O-gallate (EGCG) is the major catechin component of green tea (Cameria sinensis), and is known to possess antiviral activities against a wide range of DNA viruses and RNA viruses. However, few studies have examined chemical modifications ...

www.ncbi.nlm.nih.gov

A simple liposome assay for the screening of zinc ionophore activity of polyphenols

An efficient liposomal system for screening the zinc ionophore activity of a selected library consisting of the most relevant dietary polyphenols is p…

www.sciencedirect.com

Zinc Ionophore Activity of Quercetin and Epigallocatechin-gallate

If you research around, quercetin seems to show broad spectrum antiviral activity across the board. It's most likely due to this zinc ionophore activity.

Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry

Effect of Quercetin on Hepatitis C Virus Life Cycle: From Viral to Host Targets

Antiviral activity of four types of bioflavonoid against dengue virus type-2


Dr. Paul Marik has an interesting protocol depending on the stage


COVID Care Protocol
Last Updated 04-07-2020 5:17 p.m.

The EVMS Medical Group is providing guidance for healthcare providers treating COVID-19 patients. This approach to COVID-19 is based on the best (and most recent) available literature and the Shanghai Management Guideline for COVID.

• Download the latest EVMS Critical Care COVID-19 Protocol developed by Dr. Paul Marik.
• Download the one-page Marik COVID-19 Protocol Summary.

This protocol often changes daily. Please bookmark and share evms.edu/covidcare to find the most up-to-date version of the guidelines.

My typical daily supplementation includes 10,000iu vitamin D to keep my blood levels about 70, 6g vitamin C, 5mg melatonin, 500mg quercetin cocrystals (supposedly enhanced absorption), and 200mg EGCG. But now I’ve increased my vitamin C to 10g per day. This study below and many like it have made previous flus and colds I’ve contracted a joke.

The effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infections - PubMed

Vitamin C in megadoses administered before or after the appearance of cold and flu symptoms relieved and prevented the symptoms in the test population compared with the control group.

pubmed.ncbi.nlm.nih.gov

Like you said, it’s not corona bin the study, but mega dosing vitamin C has worked for all illnesses I’ve had since adopting this protocol 15 years ago.

Edit: I only take 7.5mg zinc picolinate from my multivitamin and taking anymore than that gives me side effects like anxiety and brain fog (detached from reality feeling). I get over 30mg zinc in my diet already, so maybe taking too much more lowers aromatase or throws off copper balance...?

 

[MarkLA]

I only take 7.5mg zinc picolinate from my multivitamin and taking anymore than that gives me side effects like anxiety and brain fog (detached from reality feeling). I get over 30mg zinc in my diet already, so maybe taking too much more lowers aromatase or throws off copper balance...?

Zinc seems to be one of the anti-viral keys. The NY Doc who has had very good results with treating Coronavirus uses HCQ + ZPack + 220 mg Zinc (!). This is for treatment, not prophylaxis and only for a few days,

I am upping my Zinc and adding Quercetin and EGCG per the suggestions from the studies. EGCG seems to have more ionophore activity, but Quercetin seems to have a longer half-life.

Previously, I think I was taking about 30mg zinc, now I will take 55mg zinc. I wasn't taking copper before but I know there's supposed to be a 10:1 Zinc:Copper ratio. That would mean 5mg Copper. I'm thinking to start with 2mg. @Nelson Vergel what are your thoughts on supplementing copper when supplementing zinc?

 

[Nelson Vergel]

what are your thoughts on supplementing copper when supplementing zinc?

I just eat a hand full of almond, cashews and sesame. That is enough copper.

 

[Nelson Vergel]

First set of data from their compassionate program. Not a randomized study. Those are to be finished in a few weeks. It is a drug given by intravenous infusion. It failed for Ebola but may work for SARS-COV2 although not for all patients.

Two thirds of COVID-19 patients improve after Gilead drug: NEJM

More than two-thirds of severely ill COVID-19 patients saw their condition improve after treatment with remdesivir, an experimental drug being developed by Gilead Sciences Inc. <GILD.O>, according to new data based on patient observation.

www.reuters.com