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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Clomid-Associated Suicide Behavior in Hypogonadal Man
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<blockquote data-quote="Stormer" data-source="post: 54535" data-attributes="member: 12916"><p>Clomid has definitely given me some really extreme depression. I get transient improvement with almost full resolution of all symptoms and return to my normal self briefly for like 2 days in the 3rd week. Then the next week I get sudden onset of depression and the depression starts to deepen and get aggravated by my personality. I am unable to tolerate negative mood states and can't stop dwelling on how I feel. Then slowly the clomid exits the system and I feel better every day. </p><p></p><p>So I'm not surprised by this at all. But I wonder if it was the Zoloft stopping that contributed in this study.</p><p></p><p>For the record Clomid gets my levels way up there to 900+ even at the low 12.5 mg eod dose. 90+% improvement in the 3rd week such that I almost feel "high on life" followed by a terrifying depression in the next week. I'm not sure but I think its the "bad" isomer accumulating over time cause zuclomiphene has a half life for 1 week while enclomiphene is 2 days. </p><p></p><p>I'm really curious what would happen if theoretically the isomers had the same half life. Or if these things were made in ratios such that the concentrations of both remained the same. And whether that would make a difference. I know you are chemE so maybe you are interested in that too reagarding the whole pharmacokinetics stuff.</p></blockquote><p></p>
[QUOTE="Stormer, post: 54535, member: 12916"] Clomid has definitely given me some really extreme depression. I get transient improvement with almost full resolution of all symptoms and return to my normal self briefly for like 2 days in the 3rd week. Then the next week I get sudden onset of depression and the depression starts to deepen and get aggravated by my personality. I am unable to tolerate negative mood states and can't stop dwelling on how I feel. Then slowly the clomid exits the system and I feel better every day. So I'm not surprised by this at all. But I wonder if it was the Zoloft stopping that contributed in this study. For the record Clomid gets my levels way up there to 900+ even at the low 12.5 mg eod dose. 90+% improvement in the 3rd week such that I almost feel "high on life" followed by a terrifying depression in the next week. I'm not sure but I think its the "bad" isomer accumulating over time cause zuclomiphene has a half life for 1 week while enclomiphene is 2 days. I'm really curious what would happen if theoretically the isomers had the same half life. Or if these things were made in ratios such that the concentrations of both remained the same. And whether that would make a difference. I know you are chemE so maybe you are interested in that too reagarding the whole pharmacokinetics stuff. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Clomid-Associated Suicide Behavior in Hypogonadal Man
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