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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Clinical Patterns of Hair Loss in Men Is DHT the Only Culprit?
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<blockquote data-quote="madman" data-source="post: 208435" data-attributes="member: 13851"><p><strong>INTRODUCTION</strong></p><p><strong></strong></p><p><strong><em>The pathophysiology of male androgenetic alopecia (AGA) has focused on the role of androgens, mainly dihydrotestosterone (DHT) and its production by 5a-reductase. </em></strong><em>Inhibitors of 5a-reductase have been developed and studied for male AGA including finasteride, which was approved by the US Food and Drug Administration for the treatment of male AGA in 1998.<strong> Overall, the important role of DHT in the pathophysiology of male AGA and as a therapeutic target has been well-established. However, there is increasing evidence of other important pathways and factors in the development and pathophysiology of male AGA, which are discussed herein.</strong></em></p><p></p><p></p><p></p><p></p><p><strong>*OXIDATIVE STRESS</strong></p><p><strong></strong></p><p><strong>*INFLAMMATION</strong></p><p><strong></strong></p><p><strong>*PROSTAGLANDINS</strong></p><p><strong></strong></p><p><strong>*VASCULOGENESIS</strong></p><p><strong></strong></p><p><strong>*WNT/b-CATENIN AND TRANSFORMING GROWTH FACTOR-b PATHWAYS</strong></p><p><strong></strong></p><p><strong>*AGING</strong></p><p><strong></strong></p><p><strong>*LIFESTYLE FACTORS AND COMORBIDITIES</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>SUMMARY </strong></p><p><strong></strong></p><p><strong><em>The role of 5a-reductase activity and DHT and its usefulness as a therapeutic target for male AGA has been well-established. Additionally, a number of other contributing factors and pathways have been investigated and shown to be involved in AGA in men. Further studies of these pathways in how they relate to AGA and how these translate to potential therapeutic options are still needed.</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 208435, member: 13851"] [B]INTRODUCTION [I]The pathophysiology of male androgenetic alopecia (AGA) has focused on the role of androgens, mainly dihydrotestosterone (DHT) and its production by 5a-reductase. [/I][/B][I]Inhibitors of 5a-reductase have been developed and studied for male AGA including finasteride, which was approved by the US Food and Drug Administration for the treatment of male AGA in 1998.[B] Overall, the important role of DHT in the pathophysiology of male AGA and as a therapeutic target has been well-established. However, there is increasing evidence of other important pathways and factors in the development and pathophysiology of male AGA, which are discussed herein.[/B][/I] [B]*OXIDATIVE STRESS *INFLAMMATION *PROSTAGLANDINS *VASCULOGENESIS *WNT/b-CATENIN AND TRANSFORMING GROWTH FACTOR-b PATHWAYS *AGING *LIFESTYLE FACTORS AND COMORBIDITIES SUMMARY [I]The role of 5a-reductase activity and DHT and its usefulness as a therapeutic target for male AGA has been well-established. Additionally, a number of other contributing factors and pathways have been investigated and shown to be involved in AGA in men. Further studies of these pathways in how they relate to AGA and how these translate to potential therapeutic options are still needed.[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Clinical Patterns of Hair Loss in Men Is DHT the Only Culprit?
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