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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
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<blockquote data-quote="madman" data-source="post: 213399" data-attributes="member: 13851"><p>Again taking such a dose is overkill!</p><p></p><p>Pissing your $$$ out the window.</p><p></p><p>The dose for <u>on-demand</u> is 10-20 mg (maximum).</p><p></p><p>The dose, when taken <u>daily</u>, is 2.5-5 mg and some may choose to run up to 10 mg (far from common).</p><p></p><p>Most men are started on 5 mg daily.</p><p></p><p>Some may end up dropping down to 2.5 mg daily if sides become unbearable.</p><p></p><p>Even if one chose to take a dose of 10 mg daily the blood levels achieved would be equivalent to taking an on-demand dose of 16 mg!</p><p></p><p></p><p></p><p><strong>Evaluation of the Efficacy and Safety of Once-a-Day Dosing of Tadalafil 5 mg and 10 mg in the Treatment of Erectile Dysfunction: Results of a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial</strong></p><p></p><p><em><strong>*Historically, tadalafil has been taken on-demand at doses of 10 or 20 mg.</strong> The ability of a drug to reach steady-state results from the frequency of administration relative to half-life. The 17.5-hour half-life of tadalafil makes it an ideal candidate for once-daily therapy because steady-state plasma concentrations are attained within five days of daily dosing, and exposure is approximately 1.6-fold greater than after a single dose [11].<strong> If <u>5-mg and 10-mg doses are taken daily</u>, a cumulative tadalafil plasma exposure equivalent to <u>on-demand doses of 8 mg and 16 mg</u>, respectively, could be achieved in a few days</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong>*the efficacy and tolerability of 5 mg tadalafil taken daily appear to be comparable to the efficacy and tolerability of 20 mg taken on-demand or every other day.</strong> Further studies that address this comparison could be useful for clinicians</em></p><p></p><p></p><p></p><p></p><p></p><p><strong>CIALIS® (Tadalafil Tablets)</strong></p><p><strong></strong></p><p><strong><u>CIALIS for “On-Demand” Dosing</u>:</strong> <em>The recommended dose is one tablet (20 mg) before sexual activity, as needed. You should NOT take more than the prescribed dose of one CIALIS 10 mg or 20 mg tablet per day. <strong>The 10 mg and 20 mg doses are not recommended for continuous daily use. </strong></em></p><p><em></em></p><p><em>You can engage in sexual activity within 30 minutes of taking the tablet and up to 36 hours later. The amount of time CIALIS takes to work varies from person to person.</em></p><p></p><p></p><p><strong><u>CIALIS for Once-a-Day Use</u>:</strong> <strong><u>Treatment of ED</u>:</strong> <em>Your doctor may recommend that you take </em><strong><em>one tablet of CIALIS (5 mg or 2.5 mg) Once-a-Day every day</em></strong><em>, at approximately the same time each day, regardless of when you are planning to have sex. </em></p><p></p><p><strong><u>Treatment of BPH and ED/BPH</u>: </strong><em>Your doctor may recommend that you take <strong>one tablet of CIALIS 5 mg Once-a-Day every day</strong>, at approximately the same time each day.</em></p></blockquote><p></p>
[QUOTE="madman, post: 213399, member: 13851"] Again taking such a dose is overkill! Pissing your $$$ out the window. The dose for [U]on-demand[/U] is 10-20 mg (maximum). The dose, when taken [U]daily[/U], is 2.5-5 mg and some may choose to run up to 10 mg (far from common). Most men are started on 5 mg daily. Some may end up dropping down to 2.5 mg daily if sides become unbearable. Even if one chose to take a dose of 10 mg daily the blood levels achieved would be equivalent to taking an on-demand dose of 16 mg! [B]Evaluation of the Efficacy and Safety of Once-a-Day Dosing of Tadalafil 5 mg and 10 mg in the Treatment of Erectile Dysfunction: Results of a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial[/B] [I][B]*Historically, tadalafil has been taken on-demand at doses of 10 or 20 mg.[/B] The ability of a drug to reach steady-state results from the frequency of administration relative to half-life. The 17.5-hour half-life of tadalafil makes it an ideal candidate for once-daily therapy because steady-state plasma concentrations are attained within five days of daily dosing, and exposure is approximately 1.6-fold greater than after a single dose [11].[B] If [U]5-mg and 10-mg doses are taken daily[/U], a cumulative tadalafil plasma exposure equivalent to [U]on-demand doses of 8 mg and 16 mg[/U], respectively, could be achieved in a few days *the efficacy and tolerability of 5 mg tadalafil taken daily appear to be comparable to the efficacy and tolerability of 20 mg taken on-demand or every other day.[/B] Further studies that address this comparison could be useful for clinicians[/I] [B]CIALIS® (Tadalafil Tablets) [U]CIALIS for “On-Demand” Dosing[/U]:[/B] [I]The recommended dose is one tablet (20 mg) before sexual activity, as needed. You should NOT take more than the prescribed dose of one CIALIS 10 mg or 20 mg tablet per day. [B]The 10 mg and 20 mg doses are not recommended for continuous daily use. [/B] You can engage in sexual activity within 30 minutes of taking the tablet and up to 36 hours later. The amount of time CIALIS takes to work varies from person to person.[/I] [B][U]CIALIS for Once-a-Day Use[/U]:[/B] [B][U]Treatment of ED[/U]:[/B] [I]Your doctor may recommend that you take [/I][B][I]one tablet of CIALIS (5 mg or 2.5 mg) Once-a-Day every day[/I][/B][I], at approximately the same time each day, regardless of when you are planning to have sex. [/I] [B][U]Treatment of BPH and ED/BPH[/U]: [/B][I]Your doctor may recommend that you take [B]one tablet of CIALIS 5 mg Once-a-Day every day[/B], at approximately the same time each day.[/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
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