Cialis versus Flomax in Men with Prostate Enlargement

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Nelson Vergel

Founder, ExcelMale.com
Treatment satisfaction with tadalafil or tamsulosin versus placebo in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: Results from a randomized, placebo-controlled study - Abstract

OBJECTIVES: To assess treatment satisfaction with tadalafil or tamsulosin versus placebo in a 12-week, randomized, double-blind study of men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH).

PATIENTS AND METHODS: Following a 4-week placebo lead-in period, men aged over 45 years with IPSS 13 received placebo (N=172), tadalafil 5-mg (N=171), or tamsulosin 0.4-mg (N=168) once daily for 12 weeks. Treatment Satisfaction Scale-BPH (TSS-BPH) responses were assessed based on median treatment differences using the van Elteren test.

RESULTS: Overall treatment satisfaction was greater for tadalafil versus placebo (p=0.005), based on greater satisfaction with efficacy (p=0.003); neither overall treatment satisfaction nor satisfaction with efficacy was greater for tamsulosin versus placebo (p&#8805;0.409). For individual questions, 66.5% of men rated tadalafil treatment as effective/very effective (Q1; versus placebo, p=0.011), 72.6% would definitely/probably recommend their treatment (Q3; p=0.043), 71.8% were generally very satisfied/satisfied with their medication (Q8; p< 0.003), and 65.0% would definitely/probably continue therapy (Q10; p=0.035). With tamsulosin, differences versus placebo were not statistically significant. Subgroup analyses of overall TSS-BPH by baseline age (65/>65), history of erectile dysfunction (yes/no), LUTS/BPH severity (IPSS < 20), total testosterone level (< 300 ng/dL), and age-specific predicted prostate volume (< 40 mL) showed no statistically significant treatment-subgroup interactions. Men with recent prior alpha-blocker therapy demonstrated greater treatment satisfaction with tadalafil versus placebo, with only borderline difference for men without prior therapy.

CONCLUSION: Treatment satisfaction was greater with tadalafil versus placebo, with no significant difference between tamsulosin and placebo.

Written by:
Oelke M, Giuliano F, Baygani SK, Melby T, Sontag A.
Department of Urology, Hannover Medical School, Hannover, Germany.
Reference: BJU Int. 2014 Mar 10. Epub ahead of print.
 
Last edited:
Defy Medical TRT clinic doctor
The erectile dysfunction drug Cialis is now approved to treat symptoms of prostate gland enlargement, the Food and Drug Administration announced today.

Cialis, manufactured by Eli Lilly and Co., was approved for the treatment of erectile dysfunction (ED ) in 2003. It can now be used to treat ED and prostate gland enlargement, or both if symptoms of the two conditions occur together, the FDA said.
 

Gene Devine

Super Moderator
The erectile dysfunction drug Cialis is now approved to treat symptoms of prostate gland enlargement, the Food and Drug Administration announced today.

Cialis, manufactured by Eli Lilly and Co., was approved for the treatment of erectile dysfunction (ED ) in 2003. It can now be used to treat ED and prostate gland enlargement, or both if symptoms of the two conditions occur together, the FDA said.


It's just a wonderful anti aging drug for men.

It has so many health benefits beyond just ED and BPH.

A low daily dose is just what the Doctor ordered:)
 

Nelson Vergel

Founder, ExcelMale.com
[Improved] Sexual Function in Men with Lower Urinary Tract Symptoms and Prostatic Enlargement Secondary to Benign Prostatic Hyperplasia: Results of a 6-Month, Randomized, Double-Blind, Placebo-Controlled Study of Tadalafil Coadministered with Finasteride


Glina S, Roehrborn CG, Esen A, et al. Sexual Function in Men with Lower Urinary Tract Symptoms and Prostatic Enlargement Secondary to Benign Prostatic Hyperplasia: Results of a 6-Month, Randomized, Double-Blind, Placebo-Controlled Study of Tadalafil Coadministered with Finasteride. J Sex Med. http://onlinelibrary.wiley.com/doi/10.1111/jsm.12714/abstract

INTRODUCTION: Tadalafil (TAD) 5 mg coadministered with finasteride (FIN) 5 mg significantly improves lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH) and prostatic enlargement. However, its effects on erectile/sexual function have yet to be fully described.

AIM: Assess the effects of TAD/FIN coadministration (compared with placebo [PBO]/FIN) on erectile and sexual function in sexually active men with LUTS and prostatic enlargement secondary to BPH with or without baseline comorbid erectile dysfunction (ED).

METHODS: A randomized, double-blind, PBO-controlled study of 695 men (610 sexually active; 450 with baseline ED; 404 sexually active with baseline ED) conducted at 70 sites in 13 countries. TAD 5 mg or PBO once daily coadministered with FIN 5 mg once daily for 26 weeks.

MAIN OUTCOME MEASURES: International Index of Erectile Function (IIEF) domain and single-item scores; proportions of patients who demonstrated minimal clinically important differences (MCIDs) in IIEF-Erectile Function domain scores (IIEF-EF; MCID defined as >/=4-point improvement); and sexual dysfunction adverse events (AEs).

RESULTS: Compared with PBO/FIN, TAD/FIN resulted in improvements for all IIEF domain and single-item scores assessed among patients with baseline ED (P </= 0.002 for all measures) and among patients without baseline ED (P </= 0.041 for all measures). Compared with PBO/FIN, significantly larger percentages of sexually active men with baseline ED treated with TAD/FIN achieved an IIEF-EF MCID after 4, 12, and 26 weeks of therapy (P < 0.001 for odds ratio comparisons between TAD/FIN and PBO/FIN at all 3three postbaseline timepoints). The incidence of sexual AEs was low: five TAD/FIN patients and seven PBO/FIN patients reported sexual AEs, including ED, decreased/lost libido, and ejaculation disorders.

CONCLUSIONS: TAD/FIN coadministration for the treatment of men with LUTS and prostatic enlargement secondary to BPH concurrently leads to statistically significant improvements in erectile/sexual function and is well-tolerated, regardless of the presence/absence of ED at treatment initiation.
 

OMI100

Member
While Cialis is approved for BPH it may be almost impossible to get it approved by your insurance company. I just Tried (BC/BS insurance). I tried all the other stuff and Cialis does work much better for me. It is listed as a PRIOR APPROVAL drug and the paperwork that your DR has to submit is a pain. Have to document that no other treatment has / will work and a bunch of other stuff..... They make it hard to jump through all the hoops so I am guessing most will never get prior approval. And that prior approval is only good for a year, than you have to jump through all the hoops again.... Just because FDA has approved its use, your insurance company may put up sooooooo many walls and road blocks that you will never get approval from them to use it. BTW it also appears that if ED is even mentioned BC/BS will automatically disapprove use EVEN if it helps with BPH
 

OMI100

Member
I have gotten some from the peptide sites. I was hoping that instead of paying for Flowmax or other similar meds I could just get the Cialis... BUT NO...... The insurance company would rather pay for the meds that don't work .....
 

BJE

Active Member
I’ve been taking 5mg Cialis Daily for several years. I would say that it has improved my prostate urinary symptoms a lot. So much so that I don’t really think about them any more. Improved erections are a pleasant side effect. My insurance covers it as a BPH treatment and now that it has gone generic I only have a $10 per month copay. Interesting though the generic brand is made by Eli Lilly and are the exact same pill as the name brand drug. Hopefully as the marked gets more flooded with generic competitors the cash price will drop to amount affordable for most men.
 

psaufan

Member
I’ve been taking 5mg Cialis Daily for several years. I would say that it has improved my prostate urinary symptoms a lot. So much so that I don’t really think about them any more. Improved erections are a pleasant side effect. My insurance covers it as a BPH treatment and now that it has gone generic I only have a $10 per month copay. Interesting though the generic brand is made by Eli Lilly and are the exact same pill as the name brand drug. Hopefully as the marked gets more flooded with generic competitors the cash price will drop to amount affordable for most men.

My insurance won't cover either. I was paying $400+ before the generic came out. I tried some of the Cialis off those sites where it was very cheap and was not pleased with what I received, (my personal experience) so I kept paying the $400+. CVS began to offer the generic, which is manufactured in Israel. I started paying $255 per month for that, but they recently dropped it to $27 per month. This is for 30 5mg tablets. Personally, I don't feel they generic work quite as good as the other (not a major difference, though), but I also realize everyone is different.
 

broker

Active Member
Any of you guys use flomax?
How old were you when you were first diagnosed with BPH ?
I do know if bph is ignored, it can lead to permanant damage to the bladder as well as kidneys.
 

BJE

Active Member
I started having BPH symptoms in my late forties. I tried Flomax but I never really noticed any effect. I’ve been on Cialis daily for several years now and for the most part my symptoms are much improved.
 
Any of you guys use flomax?
How old were you when you were first diagnosed with BPH ?
I do know if bph is ignored, it can lead to permanant damage to the bladder as well as kidneys.

Got a diagnosis of BPH and recently had a biopsy, which was negative. Have been on flomax for 2 weeks. It takes a while to tell and I should know in a week or 2. I also take daily Cialis as well.
 

Pauly_P

Member
Thanks for posting Nelson, very good information here, and great comments. Yes Mountain Man is right very low cost effective Cialis is out there. After 3 biopsy's my gland is a mess, but the Cialis does help. I might try getting back on Flomax and see if it improves anything. I have been considering focal laser ablation.
 
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