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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
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<blockquote data-quote="madman" data-source="post: 203210" data-attributes="member: 13851"><p><strong>post #37/38/43</strong></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/testosterone-in-atrevis-base-almost-double-test-levels.22498/page-2[/URL]</p><p></p><p>[ATTACH=full]15090[/ATTACH]</p><p><strong>Figure 1 Serum testosterone following three doses (12.5, 25, 50 mg) of testosterone cream applied to the scrotal skin at time zero with <u>sequential blood sampling at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 14 and 16 h</u>. Each participant underwent scheduled blood sampling after administration of each of the three doses with at least 2 days between the administration and sampling periods. S1 and S2 are two screening blood samples taken prior to the study and P1 and P2 are two blood samples taken 15 and 5 min prior to the application of the testosterone cream. Data are plotted as the mean and standard error of the mean. Biexponential curves are fitted to all the data for each dose. For further details see the text. Note conversion factors: to ng/dL multiple ng/mL by 100; to SI units multiply ng/mL by 3.47. [Colour figure can be viewed at wileyonlinelibrary.com].</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>DISCUSSION</strong></p><p></p><p>This study provides a pharmacokinetic profile of three doses of testosterone administered to the scrotal skin in a cream formulation. Application of the testosterone cream produced a rapid rise in serum testosterone peaking around 2 h after administration with a dose-dependent peak concentration, but not any consistent relationship between time of peak and testosterone dose. <strong><em>At the lowest dose (12.5 mg), <u>the serum testosterone concentrations were maintained in the physiological range for at least 12 h </u>and with the 25 mg dose <u>maintained serum testosterone concentrations within the physiological range for nearly 24 h concentration</u>.</em></strong></p><p></p><p></p><p></p><p></p><p>Take-home point: <em><strong>maintained serum testosterone concentrations within the physiological range for at least 12 h and for nearly 24 h.</strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 203210, member: 13851"] [B]post #37/38/43[/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/testosterone-in-atrevis-base-almost-double-test-levels.22498/page-2[/URL] [ATTACH type="full"]15090[/ATTACH] [B]Figure 1 Serum testosterone following three doses (12.5, 25, 50 mg) of testosterone cream applied to the scrotal skin at time zero with [U]sequential blood sampling at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 14 and 16 h[/U]. Each participant underwent scheduled blood sampling after administration of each of the three doses with at least 2 days between the administration and sampling periods. S1 and S2 are two screening blood samples taken prior to the study and P1 and P2 are two blood samples taken 15 and 5 min prior to the application of the testosterone cream. Data are plotted as the mean and standard error of the mean. Biexponential curves are fitted to all the data for each dose. For further details see the text. Note conversion factors: to ng/dL multiple ng/mL by 100; to SI units multiply ng/mL by 3.47. [Colour figure can be viewed at wileyonlinelibrary.com]. DISCUSSION[/B] This study provides a pharmacokinetic profile of three doses of testosterone administered to the scrotal skin in a cream formulation. Application of the testosterone cream produced a rapid rise in serum testosterone peaking around 2 h after administration with a dose-dependent peak concentration, but not any consistent relationship between time of peak and testosterone dose. [B][I]At the lowest dose (12.5 mg), [U]the serum testosterone concentrations were maintained in the physiological range for at least 12 h [/U]and with the 25 mg dose [U]maintained serum testosterone concentrations within the physiological range for nearly 24 h concentration[/U].[/I][/B] Take-home point: [I][B]maintained serum testosterone concentrations within the physiological range for at least 12 h and for nearly 24 h.[/B][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
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