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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Case Study: Absorption of Testosterone Cream via Scrotal Delivery
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<blockquote data-quote="Nelson Vergel" data-source="post: 129326" data-attributes="member: 3"><p>The aim of this study was to define the pharmacokinetics of testosterone delivered via the scrotal skin route. The study was a single‐center, three‐phase cross‐over pharmacokinetic study of three single doses (12.5, 25, 50 mg) of testosterone cream administered in random sequence on different days with at least 2 days between doses to healthy eugonadal volunteers with endogenous testosterone suppressed by administration of nandrolone decanoate. Serum testosterone, DHT and estradiol concentrations were measured by liquid chromatograpy, mass spectrometry in extracts of serum taken before and for 16 h after administration of each of the three doses of testosterone cream to the scrotal skin. Testosterone administration onto the scrotal skin produced a swift (peak 1.9–2.8 h), dose‐dependent (p < 0.0001) increase in serum testosterone with the 25 mg dose maintaining physiological levels for 16 h. Serum DHT displayed a time‐ (p < 0.0001), but not dose‐dependent, increase in concentration reaching a peak concentration of 1.2 ng/mL (4.1 nm) at 4.9 h which was delayed by 2 h after peak serum testosterone. There were no significant changes in serum estradiol over time after testosterone administration. We conclude that testosterone administration to scrotal skin is well tolerated and produces dose‐dependent peak serum testosterone concentration with a much lower dose relative to the non‐scrotal transdermal route.</p><p></p><p>"The bioavailability of testosterone via the scrotal skin is striking higher than for abdominal skin. Using the same testosterone cream and steroid LC‐MS assay measurements, in this study a Cmax (4.6 ng/mL, 16.0 nm) was achieved with the lowest dose (12.5 mg) applied to the scrotal skin whereas applying 100 mg testosterone cream to the abdominal skin produced a Cmax of 16.3 nmol/L (4.7 ng/mL).<strong> This suggests an about eightfold increase in testosterone bioavailability, using the scrotal compared with abdominal ski</strong>n routes. "</p><p></p><p>"<strong>Testosterone administration to the scrotal skin also produced a marked rise in serum DHT following each testosterone dose</strong>, but neither the time of peak nor the peak DHT concentration were dose dependent."</p><p></p><p>Source:</p><p><strong>Pharmacokinetics of testosterone cream applied to scrotal skin</strong></p><p>R. Iyer</p><p>Andrology. Volume5, Issue4</p><p>July 2017</p><p>Pages 725-731 </p><p></p><p>[ATTACH=full]6284[/ATTACH]</p><p></p><p>[ATTACH=full]6285[/ATTACH]</p><p>[ATTACH=full]6286[/ATTACH]</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 129326, member: 3"] The aim of this study was to define the pharmacokinetics of testosterone delivered via the scrotal skin route. The study was a single‐center, three‐phase cross‐over pharmacokinetic study of three single doses (12.5, 25, 50 mg) of testosterone cream administered in random sequence on different days with at least 2 days between doses to healthy eugonadal volunteers with endogenous testosterone suppressed by administration of nandrolone decanoate. Serum testosterone, DHT and estradiol concentrations were measured by liquid chromatograpy, mass spectrometry in extracts of serum taken before and for 16 h after administration of each of the three doses of testosterone cream to the scrotal skin. Testosterone administration onto the scrotal skin produced a swift (peak 1.9–2.8 h), dose‐dependent (p < 0.0001) increase in serum testosterone with the 25 mg dose maintaining physiological levels for 16 h. Serum DHT displayed a time‐ (p < 0.0001), but not dose‐dependent, increase in concentration reaching a peak concentration of 1.2 ng/mL (4.1 nm) at 4.9 h which was delayed by 2 h after peak serum testosterone. There were no significant changes in serum estradiol over time after testosterone administration. We conclude that testosterone administration to scrotal skin is well tolerated and produces dose‐dependent peak serum testosterone concentration with a much lower dose relative to the non‐scrotal transdermal route. "The bioavailability of testosterone via the scrotal skin is striking higher than for abdominal skin. Using the same testosterone cream and steroid LC‐MS assay measurements, in this study a Cmax (4.6 ng/mL, 16.0 nm) was achieved with the lowest dose (12.5 mg) applied to the scrotal skin whereas applying 100 mg testosterone cream to the abdominal skin produced a Cmax of 16.3 nmol/L (4.7 ng/mL).[B] This suggests an about eightfold increase in testosterone bioavailability, using the scrotal compared with abdominal ski[/B]n routes. " "[B]Testosterone administration to the scrotal skin also produced a marked rise in serum DHT following each testosterone dose[/B], but neither the time of peak nor the peak DHT concentration were dose dependent." Source: [B]Pharmacokinetics of testosterone cream applied to scrotal skin[/B] R. Iyer Andrology. Volume5, Issue4 July 2017 Pages 725-731 [ATTACH=full]6284[/ATTACH] [ATTACH=full]6285[/ATTACH] [ATTACH=full]6286[/ATTACH] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Case Study: Absorption of Testosterone Cream via Scrotal Delivery
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