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Expert Interviews
Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck
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<blockquote data-quote="Nelson Vergel" data-source="post: 7037" data-attributes="member: 3"><p>A case report just published by Glueck</p><p></p><p>Blood Coagulation & Fibrinolysis:</p><p><a href="http://journals.lww.com/bloodcoagulation/pages/currenttoc.aspx" target="_blank">April 2014 - Volume 25 - Issue 3 - p 286-288</a></p><p>doi: 10.1097/MBC.0000000000000047</p><p>Case Reports</p><p></p><p>Testosterone, anastrozole, factor V Leiden heterozygosity and osteonecrosis of the jaws, Ramesh S.; Glueck, Charles J.</p><p></p><p></p><p></p><p></p><p>Our specific aim is to describe the development of thrombotic osteonecrosis of the jaws after testosterone diagnosed factor V Leiden heterozygosity. Before the diagnosis of V Leiden heterozygosity, he was given testosterone gel, 50mg/day, and on testosterone, serum testosterone (963ng/dl) and estradiol were high (50pg/ml). Anastrozole was started, and testosterone was continued. Six months later, osteonecrosis of the jaws was diagnosed. Exogenous testosterone is aromatized to estradiol and estradiol-induced thrombophilia, when superimposed on underlying familial thrombophilia, as in this case, may lead to thrombosis and osteonecrosis. We recommend that before giving testosterone, at a minimum, screening for the factor V Leiden and G20210A mutations, and factor VIII and XI activity be carried out, to avoid unanticipated thrombosis.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 7037, member: 3"] A case report just published by Glueck Blood Coagulation & Fibrinolysis: [URL='http://journals.lww.com/bloodcoagulation/pages/currenttoc.aspx']April 2014 - Volume 25 - Issue 3 - p 286-288[/URL] doi: 10.1097/MBC.0000000000000047 Case Reports Testosterone, anastrozole, factor V Leiden heterozygosity and osteonecrosis of the jaws, Ramesh S.; Glueck, Charles J. Our specific aim is to describe the development of thrombotic osteonecrosis of the jaws after testosterone diagnosed factor V Leiden heterozygosity. Before the diagnosis of V Leiden heterozygosity, he was given testosterone gel, 50mg/day, and on testosterone, serum testosterone (963ng/dl) and estradiol were high (50pg/ml). Anastrozole was started, and testosterone was continued. Six months later, osteonecrosis of the jaws was diagnosed. Exogenous testosterone is aromatized to estradiol and estradiol-induced thrombophilia, when superimposed on underlying familial thrombophilia, as in this case, may lead to thrombosis and osteonecrosis. We recommend that before giving testosterone, at a minimum, screening for the factor V Leiden and G20210A mutations, and factor VIII and XI activity be carried out, to avoid unanticipated thrombosis. [/QUOTE]
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Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck
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