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Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck
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<blockquote data-quote="Concerned wife" data-source="post: 27102" data-attributes="member: 12457"><p>This is a little off the subject, but I wonder if doctors of women having issues are refusing them hormone therapy because of the risks? I have a female friend with Factor V Leiden and she has resisted pharmaceutical blood thinners. </p><p></p><p>This is an excerpt of the benefit versus risk ratio for these patients. I am sure some suffering women are willing to take their chances for a better quality of life:</p><p></p><p><strong>What Are the Special Considerations for Women With Factor V Leiden?</strong></p><p></p><p><strong>Hormone Use</strong></p><p></p><p>The use of hormones, such as oral contraceptive pills (OCPs) and hormone replacement therapy (HRT, including estrogen and estrogen-like drugs) taken after menopause, increases the risk of developing DVT and PE. Healthy women taking OCPs have a 3- to 4-fold increased risk of developing a DVT or PE compared with women who do not take OCP. Women with factor V Leiden who take OCPs have about a 35-fold increased risk of developing a DVT or PE compared with women without factor V Leiden and those who do not take OCPs. This would translate to an about 35 per 10 000 chance per year of use on average for women in their twenties with factor V Leiden. Likewise, postmenopausal women taking HRT have a 2- to 3-fold higher risk of developing a DVT or PE than women who do not take HRT, and women with factor V Leiden who take HRT have a 15-fold higher risk. This is about a 15 to 40 per 1000 chance per year of use, on average, for women in their fifties with factor V Leiden. Women with heterozygous factor V Leiden who are making decisions about OCP or HRT use should take these statistics into consideration when weighing the risks and benefits of treatment.</p></blockquote><p></p>
[QUOTE="Concerned wife, post: 27102, member: 12457"] This is a little off the subject, but I wonder if doctors of women having issues are refusing them hormone therapy because of the risks? I have a female friend with Factor V Leiden and she has resisted pharmaceutical blood thinners. This is an excerpt of the benefit versus risk ratio for these patients. I am sure some suffering women are willing to take their chances for a better quality of life: [B]What Are the Special Considerations for Women With Factor V Leiden?[/B] [B]Hormone Use[/B] The use of hormones, such as oral contraceptive pills (OCPs) and hormone replacement therapy (HRT, including estrogen and estrogen-like drugs) taken after menopause, increases the risk of developing DVT and PE. Healthy women taking OCPs have a 3- to 4-fold increased risk of developing a DVT or PE compared with women who do not take OCP. Women with factor V Leiden who take OCPs have about a 35-fold increased risk of developing a DVT or PE compared with women without factor V Leiden and those who do not take OCPs. This would translate to an about 35 per 10 000 chance per year of use on average for women in their twenties with factor V Leiden. Likewise, postmenopausal women taking HRT have a 2- to 3-fold higher risk of developing a DVT or PE than women who do not take HRT, and women with factor V Leiden who take HRT have a 15-fold higher risk. This is about a 15 to 40 per 1000 chance per year of use, on average, for women in their fifties with factor V Leiden. Women with heterozygous factor V Leiden who are making decisions about OCP or HRT use should take these statistics into consideration when weighing the risks and benefits of treatment. [/QUOTE]
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Expert Interviews
Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck
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