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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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<blockquote data-quote="xqfq" data-source="post: 189406" data-attributes="member: 38167"><p>Based on the quote from madman:</p><p></p><p>"Based on the new data on the distribution of free testosterone levels in healthy men the target range of free testosterone has been determined to be 164 to 314 pg/ml (mean+/−1SD)"</p><p></p><p>I took the 'range' to not mean a 'range of a random selection of blood samples' but rather an effort to identify the 'therapeutic range' for healthy men's free T level[1]. Unfortunately, I cannot find a source for this quote, though I did find some information in a patent filing:</p><p></p><p>[URL unfurl="true"]https://patents.google.com/patent/WO2014138026A1/en[/URL]</p><p></p><p>[ATTACH]11233[/ATTACH]</p><p></p><p>I remember reading something more concrete on this 'range' a while ago, but I can't find it now.</p><p></p><p>1. To the best of my knowledge, there is no published paper on such a therapeutic range, though it would be very valuable. The 'healthy non-obese' subjects used in the latest labcorp range are majority-prediabetic and majority-prehypertensive, for instance. I also have concerns about a BMI shift over time, wherein the average fat mass of a male now is likely higher than it was, say, 30 years ago. The study which labcorp draws its range from (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460736/" target="_blank">Harmonized Reference Ranges for Circulating Testosterone Levels in Men of Four Cohort Studies in the United States and Europe</a>) does not 'adjust' for this likely BMI shift, but instead simply excludes anyone with BMI >= 30. A study which also measured things like energy levels, libido, mood / depression, would be much more valuable. Instead, the range likely reflects an increasingly sick population.</p><p></p><p>On this subject, [MEDIA=youtube]EhP5RvXBi7s:276[/MEDIA] is an interesting discussion about age-related decline and when to initiate therapy.</p></blockquote><p></p>
[QUOTE="xqfq, post: 189406, member: 38167"] Based on the quote from madman: "Based on the new data on the distribution of free testosterone levels in healthy men the target range of free testosterone has been determined to be 164 to 314 pg/ml (mean+/−1SD)" I took the 'range' to not mean a 'range of a random selection of blood samples' but rather an effort to identify the 'therapeutic range' for healthy men's free T level[1]. Unfortunately, I cannot find a source for this quote, though I did find some information in a patent filing: [URL unfurl="true"]https://patents.google.com/patent/WO2014138026A1/en[/URL] [ATTACH alt="Screen Shot 2020-10-22 at 2.58.30 PM.png"]11233[/ATTACH] I remember reading something more concrete on this 'range' a while ago, but I can't find it now. 1. To the best of my knowledge, there is no published paper on such a therapeutic range, though it would be very valuable. The 'healthy non-obese' subjects used in the latest labcorp range are majority-prediabetic and majority-prehypertensive, for instance. I also have concerns about a BMI shift over time, wherein the average fat mass of a male now is likely higher than it was, say, 30 years ago. The study which labcorp draws its range from ([URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460736/']Harmonized Reference Ranges for Circulating Testosterone Levels in Men of Four Cohort Studies in the United States and Europe[/URL]) does not 'adjust' for this likely BMI shift, but instead simply excludes anyone with BMI >= 30. A study which also measured things like energy levels, libido, mood / depression, would be much more valuable. Instead, the range likely reflects an increasingly sick population. On this subject, [MEDIA=youtube]EhP5RvXBi7s:276[/MEDIA] is an interesting discussion about age-related decline and when to initiate therapy. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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