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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Brain estrogen creation 'critical to maintain full sexual activity or desire in males'
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<blockquote data-quote="Cataceous" data-source="post: 186919" data-attributes="member: 38109"><p>This work supports the idea. "These data suggest that aromatase is necessary for sexual activity in male mice. Testicular aromatase plays a dominant role in male sexual behavior, but <strong>brain aromatase specifically contributes to regulating the initiation and frequency of sexual activity</strong>."</p><p></p><p>In trying to tease out more details the authors found that castrated mice lacking brain aromatase could have sexual behavior "rescued" with a combination of exogenous testosterone and estrogen, but not testosterone alone. Castrated control mice could be "rescued" with exogenous testosterone alone. "Taken together, our findings indicate that a combination of T and E2 is required to rescue appropriate sexual behavior in mice with deficient E2 production in the brain."</p><p></p><p></p><p></p><p>This latter part is less certain, as treatment with exogenous estradiol helped the mice regain sexual behavior. As a practical matter, the side effects of sufficient doses of exogenous estradiol could make this treatment impractical in human males.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 186919, member: 38109"] This work supports the idea. "These data suggest that aromatase is necessary for sexual activity in male mice. Testicular aromatase plays a dominant role in male sexual behavior, but [B]brain aromatase specifically contributes to regulating the initiation and frequency of sexual activity[/B]." In trying to tease out more details the authors found that castrated mice lacking brain aromatase could have sexual behavior "rescued" with a combination of exogenous testosterone and estrogen, but not testosterone alone. Castrated control mice could be "rescued" with exogenous testosterone alone. "Taken together, our findings indicate that a combination of T and E2 is required to rescue appropriate sexual behavior in mice with deficient E2 production in the brain." This latter part is less certain, as treatment with exogenous estradiol helped the mice regain sexual behavior. As a practical matter, the side effects of sufficient doses of exogenous estradiol could make this treatment impractical in human males. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Brain estrogen creation 'critical to maintain full sexual activity or desire in males'
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