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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Brain estrogen creation 'critical to maintain full sexual activity or desire in males'
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<blockquote data-quote="Cataceous" data-source="post: 186908" data-attributes="member: 38109"><p>If <a href="https://www.ironmagazine.com/2015/the-battle-of-the-aromatase-inhibitors/" target="_blank">this article</a> is accurate then anastrozole is relatively safe in this regard due to reduced penetration of the blood-brain barrier:</p><p></p><p style="margin-left: 20px"><em>Another seldom considered aspect of A.I. use is their effect on brain function. While all A.I.’s affect the level of estrogen exposure in the brain, both letrozole and exemestane demonstrate an increased aptitude for crossing the blood-brain barrier, making them capable of adversely affecting neurosteroid balance to a greater degree than anastrozole. Along with enhanced blood-brain permeability, letrozole also suffers from a reduced clearance rate, allowing concentrations within the brain to climb even higher. While exemestane clears more quickly, its permanent deactivation of aromatase makes it equally problematic in this regard, as the body must first produce additional aromatase before proper neurosteroid balance can be restored.</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>Due to its greater specificity of action (less apt to interfere with non-target tissues), anastrozole has the clear advantage in this area. It does not penetrate the blood brain barrier as readily, making it much less likely to cause side effects such as sexual dysfunction, libido issues, or depression. Letrozole also appears to negatively impact cellular response to estrogen in areas of the brain that help govern mood, leaning, and memory. Lastly, exemestane and letrozole can disrupt steroid production within the adrenal cortex, while anastrozole does not. Many of the side effects associated with neurosteroid imbalance, such as sexual dysfunction, reduced libido, and depression, have been reported in those who use letrozole. Although exemestane appears to be less problematic in these areas, one could postulate that this is largely due to the infrequent dosing patterns employed by those who use the drug, rather than a diminished ability to affect neurosteroid balance.</em></p></blockquote><p></p>
[QUOTE="Cataceous, post: 186908, member: 38109"] If [URL='https://www.ironmagazine.com/2015/the-battle-of-the-aromatase-inhibitors/']this article[/URL] is accurate then anastrozole is relatively safe in this regard due to reduced penetration of the blood-brain barrier: [INDENT][I]Another seldom considered aspect of A.I. use is their effect on brain function. While all A.I.’s affect the level of estrogen exposure in the brain, both letrozole and exemestane demonstrate an increased aptitude for crossing the blood-brain barrier, making them capable of adversely affecting neurosteroid balance to a greater degree than anastrozole. Along with enhanced blood-brain permeability, letrozole also suffers from a reduced clearance rate, allowing concentrations within the brain to climb even higher. While exemestane clears more quickly, its permanent deactivation of aromatase makes it equally problematic in this regard, as the body must first produce additional aromatase before proper neurosteroid balance can be restored.[/I][/INDENT] [INDENT][I][/I][/INDENT] [INDENT][I]Due to its greater specificity of action (less apt to interfere with non-target tissues), anastrozole has the clear advantage in this area. It does not penetrate the blood brain barrier as readily, making it much less likely to cause side effects such as sexual dysfunction, libido issues, or depression. Letrozole also appears to negatively impact cellular response to estrogen in areas of the brain that help govern mood, leaning, and memory. Lastly, exemestane and letrozole can disrupt steroid production within the adrenal cortex, while anastrozole does not. Many of the side effects associated with neurosteroid imbalance, such as sexual dysfunction, reduced libido, and depression, have been reported in those who use letrozole. Although exemestane appears to be less problematic in these areas, one could postulate that this is largely due to the infrequent dosing patterns employed by those who use the drug, rather than a diminished ability to affect neurosteroid balance.[/I][/INDENT] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Brain estrogen creation 'critical to maintain full sexual activity or desire in males'
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