Blood levels of pregnenolone after a year on 400mg a day

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Anonymon

Active Member
It’s been almost a year since I started taking 400mg of pregnenolone a day in the morning on an empty stomach. I’ve tried different brands but settled on the Double Wood brand from Amazon for the price and effectiveness. Had a brief time where I tried stopping here and there and didn’t feel as good, so I just went back, but it’s mostly been 400mg a day for nearing a year.

Before all these, my pregnenolone blood test was somewhere around 23. On 100mg, at Quest labs it came out at 73. After a almost year on 400mg, from Labcorp, it came back at 104. This is all in ng/dL.

The rest of my protocol’s varied a bit, but the core of it during the last two tests was 24mg of test-c daily, 720iu’s HCG 3x a week, HGH peptides in the evening 5x a week, and various thyroid med combinations. More HCG didn’t seem to have any significant impact on my pregnenolone levels during tests compared to smaller amounts, though I do still feel better on that amount in ways similar to taking pregnenolone.

I tend to have low cortisol and have extensive experience replacing it and trying different things for related hormones, which include hydrocortisone, cortisone acetate, fludrocortisone, rhodiola, adrenal cortex, and pretty much anything you can throw at it. I’ve done transdermal pregnenolone, progesterone, you name it. My thyroid levels also tend to come back low, so I’ve done anything you could think of with NDT, T4, and T3 in their various formats. For me, pregnenolone does raise my resting heart rate in a dose dependent manner, about 1bpm per 100mg. Goes up and down accordingly any time I made a change there. Blood pressure didn’t change much. Does cause a bit of water retention in my stomach and legs and lower back, maybe a bit on the face too. Raises my libido a lot when on thyroid meds. Also helps give me the ability to sweat in response to things, which I lack without it unfortunately.

Comparing things, I get a lot of the benefits from replacing cortisol with cortisone acetate but without the sides. Not all, but many. We’ll find out how much it affected my morning cortisol because that test isn’t back yet, but on the last tests it didn’t really seem to help there. The biggest benefit for me is likely one that I saw in one study, which saw a dose dependent increase in dopamine in response to different things when supplementing pregnenolone. My latest experiments with Selegiline at 2.5mg a day under the tongue in the morning seem to confirm that, which works synergistically with it.

Seems like when you supplement pregnenolone, your body is going to preferentially convert it to things and try to use it up over increasing your stores of it. At least in my case. I came into all this with PFS, so the allopregnenolone conversion likely benefits me a lot. Sucks that my blood test scores on it seem to have a cap, but I do get the benefits of it, so I’m not too sad about that. Main downside for me is that it’s technically one of the priciest things I do to take that much of it. 200mg a day was acceptable, but 400mg for me is where I prefer to be in terms of mental wellbeing and libido and being able to sweat and be more normal after PFS.

Extremely synergistic with T3 / liothyronine. If I’m on preg with little hits of that throughout the day, in as little as 18.75mcg of T3 or up to 30-40mcg T3 a day, and I have a good base of T4 built up, I think about sex pretty much all day and my dick might even get too hard. I do microdose cialis daily at 2.5-10mg, but it doesn’t do anything if I don’t have everything else in place because I can’t feel my penis as much for the blood flow to happen. I’m taking more cialis now because I had to get some weird amino version and it seems like it’s half as effective so I take more, and it was getting to be annoying cutting the pills that small.

For libido and mental well being, if my thyroid levels are looking good, pregnenolone has been one of the most effective things in my protocol. Add in some selegiline, and at least mentally I feel great. So great it takes some getting used to because I can get caught up in pretty much anything if I’m not careful. Even without the selegiline, however, things were great on most fronts, sans glycogen retention and dehydration, which I still struggle with.

Feel free to ask any questions and over time I’ll do my best to answer them because a lot of people over time have asked me about this.
 
Defy Medical TRT clinic doctor

newuser

Member
I’ve done transdermal pregnenolone, progesterone, you name it. My thyroid levels also tend to come back low, so I’ve done anything you could think of with NDT, T4, and T3 in their various formats. For me, pregnenolone does raise my resting heart rate in a dose dependent manner, about 1bpm per 100mg. Goes up and down accordingly any time I made a change there. Blood pressure didn’t change much. Does cause a bit of water retention in my stomach and legs and lower back, maybe a bit on the face too.
You prefer oral pregnenolone then trandermal. What difference have you noticed between those routes of administration? Doesn't oral preg convert mostly to progesterone and DHEA(incresed heart rate+estrogen+water retention)?
 

Mastodont

Active Member
It seems that particular product is non-micronized, just plain pregnenolone, i also have very low levels, but for some reason cannot tolerate pregnenolone capsules, they make me lethargig during the day even at 30mg, micronised version is different and gives energy and dopamine boost, but sleep is affected too much.
 

Anonymon

Active Member
It seems that particular product is non-micronized, just plain pregnenolone, i also have very low levels, but for some reason cannot tolerate pregnenolone capsules, they make me lethargig during the day even at 30mg, micronised version is different and gives energy and dopamine boost, but sleep is affected too much.
I’ve tried the micronized kinds, like Klaire Labs and many others, and of them Klaire Labs would be my pick for the price. I didn’t notice any difference between theirs and Double Wood though, and Double Wood’s cheaper, so I settled on that. Plenty of times I was on Klaire Labs and other micronized ones.

Other kinds didn’t do anything for me at all, like the Life Extension brand. Like I was taking fake pills.
 

Anonymon

Active Member
You prefer oral pregnenolone then trandermal. What difference have you noticed between those routes of administration? Doesn't oral preg convert mostly to progesterone and DHEA(incresed heart rate+estrogen+water retention)?
There are the theoretical pathways of conversion, and what actually happens to you when you try it, and in my case my DHEA wasn’t up. I had that tested throughout. When I was on DHEA at 50-75mg my DHEA-Sulfate was in the high 200s low 300s as I recall over time. Dropping that but on all that preg and I was in the 90’s, just under the reference range for DHEA. I noticed a big difference in stopping DHEA vs taking it and although mentally I liked DHEA, I‘m better off without it with my low cortisol as they compete. On preg, I didn’t notice any of the things I’d notice on DHEA, and my DHEA levels on blood tests were not elevated. They were even a hair low.

For transdermal, I seemed to adapt to it pretty quickly. It made me mentally feel calmer and have an elevated mood but that was most of it, then nothing. I was on that plenty of times throughout this but stopped and didn’t even notice it was gone at that point. For oral, everything was better at a higher dose. Libido, mood, energy, I could sweat when needed. Transdermal, I went up to 75mg a day as I recall. It was nice at first but then tapered off. With oral, there was a little tapering but it was mostly just the same indefinitely. My E2 wasn’t elevated on preg from what it was at before. Little bit of water retention and it did increase my heart rate 1bmp per 100mg, which isn’t much.

I’m coming at this from PFS, so my conversion pathways may be altered from some folks.
 

Mastodont

Active Member
I’ve tried the micronized kinds, like Klaire Labs and many others, and of them Klaire Labs would be my pick for the price. I didn’t notice any difference between theirs and Double Wood though, and Double Wood’s cheaper, so I settled on that. Plenty of times I was on Klaire Labs and other micronized ones.

Other kinds didn’t do anything for me at all, like the Life Extension brand. Like I was taking fake pills.
That´s funny, life extension is ruining my sleep, can also feel it, there might definitely be individualism in what the oral pregs are converted to.
 

Nelson Vergel

Founder, ExcelMale.com
@Anonymon Thanks for sharing. I have been looking for someone that has tried the higher dose of pregnenolone! Strange that the blood level did not increase more than that with 400 mg/day. When you used Labcorp, did you get the LC/MS test or the regular immunoassay?

Interesting to see that your heart rate increased but not your BP.

100 mg pf preg brought me up to 95 ng/dL. I had no chance to test at 400 mg/d since my BP went up dramatically.

All data on mood was generated using high doses up to 500 mg/day.

I felt really good at 400 mg/day and I wish I did not have to deal with high BP which would require for me to go beyond my calcium channel blocker. I really do not want to take combo therapy for BP!
 

Anonymon

Active Member
That´s funny, life extension is ruining my sleep, can also feel it, there might definitely be individualism in what the oral pregs are converted to.
Since we’re getting this stuff from Amazon in most cases, there’s also the chance that some of it’s not actually what’s in the bottle. That’s partly why I try to stick to brands I like and trust. Klaire Labs is good. Double Wood’s good. Gaia Herbs is good though I don’t know if they have any preg in any higher doses.
 

Anonymon

Active Member
@Anonymon Thanks for sharing. I have been looking for someone that has tried the higher dose of pregnenolone! Strange that the blood level did not increase more than that with 400 mg/day. When you used Labcorp, did you get the LC/MS test or the regular immunoassay?

Interesting to see that your heart rate increased but not your BP.

100 mg pf preg brought me up to 95 ng/dL. I had no chance to test at 400 mg/d since my BP went up dramatically.

All data on mood was generated using high doses up to 500 mg/day.

I felt really good at 400 mg/day and I wish I did not have to deal with high BP which would require for me to go beyond my calcium channel blocker. I really do not want to take combo therapy for BP!
When I used Quest it was LC/MS, but Labcorp was MS as that’s all I had access to when buying tests. Would have been nice to have both at Quest with the same test but my doc switched to Labcorp.

When you took your pregnenolone, did you take it all at once in the morning or night, or spread it out throughout the day? I’m playing with other things right now but trying to spread it out throughout the day would be another thing I wanted to try, maybe 200 in the morning and 200 afternoon. I tried taking 30mg 3x a day before but it didn’t do much for me and may have just made me anxious if anything.

I’ve always been weird with blood pressure and heart rate. Before all this my blood pressure was always veering too low. More sodium actually decreases my heart rate.
 

Anonymon

Active Member
Got off with my doc just now, and as a further update, my DHEA-Sulfate levels on 400mg of pregnenolone were actually in the 60’s, which is pretty low despite all the HCG on top of that. SHBG was better than ever at 31 from 25ish. Not much better but still better. Morning cortisol was 8.4 or so as I recall, a little lower than last time which was around 10 at that dose of preg.
 

RP McMurphy

New Member
I take 150 mg of pregnenolone daily. I like the micronized version by Allergy Research Group. Taking it has been a game changer for me, as my levels were non detectable after extensive toxic mold exposure. One thing I’ve found re testing…I usually take my dose in the morning, but based on the recommendation of a doc I trust, for three days prior to any labs I switch my dose to nightly. The lab values always show up higher when I do this, and tend to think they’re more indicative of actual levels. Dr. Mark Gordon instructs patients to take DHEA and pregnenolone at night…if I remember correctly for synergistic effects with growth hormone production.
 

Anonymon

Active Member
Is your doctor scripting you for cortisone acetate?
No. I had a personal connection for that but that’s since gone belly up so I don’t have access anymore. Which sucks because T4 + that was actually pretty great in most ways. I had some bad things happen that I had attributed to that at the time but figured out it was something else. Really wish all these underground sites would offer cortisone acetate over hydrocortisone.

I still have a bunch but wanted another long term solution because I knew I couldn’t get it forever, whereas T4 and T3 and things like that are everywhere.
 

Dicky

Active Member
No. I had a personal connection for that but that’s since gone belly up so I don’t have access anymore. Which sucks because T4 + that was actually pretty great in most ways. I had some bad things happen that I had attributed to that at the time but figured out it was something else. Really wish all these underground sites would offer cortisone acetate over hydrocortisone.

I still have a bunch but wanted another long term solution because I knew I couldn’t get it forever, whereas T4 and T3 and things like that are everywhere.
That's too bad your source fell through. I like hydrocortisone, but don't like how it metabolizes so fast. This aspiring physician Hormetheus – Medium used Acetate with good results. I wish I was able to try it out.

EDIT: I just looked at Hormetheus' blog. It is not rendering properly for me. Not sure if he took the content down or what. It would not surprise me if he did. He was a med student and he talked about replacing all of his major hormones. Something that is pretty controversial.
 
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Anonymon

Active Member
That's too bad your source fell through. I like hydrocortisone, but don't like how it metabolizes so fast. This aspiring physician Hormetheus – Medium used Acetate with good results. I wish I was able to try it out.
He ended up coming off everything after playing around with MAO inhibitors like I am and attributed all his issues to stress and a bad cutting cycle when he was a kid. He also tried to take down everything he wrote in most places as I recall, presumably to avoid leading people down the rabbit hole he fell down and for legal reasons. Everyone should always exercise a lot of caution when reading the accounts of others doing a bunch of things as we’re all different and learning when it comes to this.

Having played around with everything and more than most people can get access to, at least in my case I got a lot of the same benefits as being on T4 + cortisone as I did when simply doing a low carb diet, and being potentially ketogenic some of the time. In my case I couldn’t keep doing that, however, because it lowered my T3 too much and made some debilitating gut issues a lot worse and ruined my already poor sleep at the time. Sleep now is great, though depending on my thyroid and diet I might be a little too tired in the morning. Originally my experience with T4 and cortisone made me think the cortisone caused some massive issues but I found out much later that it was something else.

Right now I’m actually trying to go down on T3 again and get by with just T4 and go lower carb again. Lower carb and higher fat seems to up dopamine levels, and since that’s my general trend that I’m going for, I want to see if I can make it work now that some of my gut issues are healed. I also want to do it because T3 ruins my already ruined glycogen retention as I’m really sensitive to it, and carbs in general require a lot of hydration that my body sucks at after finasteride. Carbs using up water to process is probably why they bring so much water into the body, but I suck at that right now. If I eat more without T3, I get dehydration marks on my face and my skin gets really dry and bad.

Cortisone and T4 together raised my fasting insulin without lowering my cortisol, which for me is good, and I’m trying to see if I can do that with T4 and adrenal glandulars as just the cortex didn’t really work well for me. Even on T4 and T3 with the whole glandular my glycogen retention starts shooting up and my A1C is more normal, before having been too low. Last time it was 5.1, which for me is probably the highest it’s ever been. Pregnenolone didn’t help my A1C at all and I still had a low 3’s A1C on it back in February. My experience being on levothyroxine and even just a little bit of the lowest dose of Pure brand Adrenal Glandular was similar to being on a low dose of cortisone with levothyroxine in a way that built up day over day. It’s not from the aldosterone in it as fludrocortisone actually makes things for me a lot worse, especially if I eat potassium as it just shoots it out of my body. There is likely dopamine in the glandular but for me and the other issues it helps with, it might be that it has cortisone in there, or that I’m able to deactive the cortisol in it in a way that my body can’t do with hydrocortisone. Or something completely different I’ll learn years later if ever, but that’s where I’m at.

It also helps me tolerate DHEA, which competes with cortisol. I dropped it because it helped with some things but mine is really low despite all the preg and HCG, and I do like the mental benefits I got from 50mg a day in the morning, so I’m also back on that.

The adrenal glandular also gives me a normal person’s body odor, which cortisone was one of the only other things that allowed that. Without that even if I can get myself to sweat there’s no odor. Sounds weird as a positive outcome but I’m always happy with anything that brings me closer to being human again.
 
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Gman86

Member
I take 150 mg of pregnenolone daily. I like the micronized version by Allergy Research Group. Taking it has been a game changer for me, as my levels were non detectable after extensive toxic mold exposure. One thing I’ve found re testing…I usually take my dose in the morning, but based on the recommendation of a doc I trust, for three days prior to any labs I switch my dose to nightly. The lab values always show up higher when I do this, and tend to think they’re more indicative of actual levels. Dr. Mark Gordon instructs patients to take DHEA and pregnenolone at night…if I remember correctly for synergistic effects with growth hormone production.
What benefits have u noticed since taking 150mg of preg? I definitely think I lived in a house with black mold for many years
 

Gianluca

Well-Known Member
It’s been almost a year since I started taking 400mg of pregnenolone a day in the morning on an empty stomach. I’ve tried different brands but settled on the Double Wood brand from Amazon for the price and effectiveness. Had a brief time where I tried stopping here and there and didn’t feel as good, so I just went back, but it’s mostly been 400mg a day for nearing a year.

Before all these, my pregnenolone blood test was somewhere around 23. On 100mg, at Quest labs it came out at 73. After a almost year on 400mg, from Labcorp, it came back at 104. This is all in ng/dL.

The rest of my protocol’s varied a bit, but the core of it during the last two tests was 24mg of test-c daily, 720iu’s HCG 3x a week, HGH peptides in the evening 5x a week, and various thyroid med combinations. More HCG didn’t seem to have any significant impact on my pregnenolone levels during tests compared to smaller amounts, though I do still feel better on that amount in ways similar to taking pregnenolone.

I tend to have low cortisol and have extensive experience replacing it and trying different things for related hormones, which include hydrocortisone, cortisone acetate, fludrocortisone, rhodiola, adrenal cortex, and pretty much anything you can throw at it. I’ve done transdermal pregnenolone, progesterone, you name it. My thyroid levels also tend to come back low, so I’ve done anything you could think of with NDT, T4, and T3 in their various formats. For me, pregnenolone does raise my resting heart rate in a dose dependent manner, about 1bpm per 100mg. Goes up and down accordingly any time I made a change there. Blood pressure didn’t change much. Does cause a bit of water retention in my stomach and legs and lower back, maybe a bit on the face too. Raises my libido a lot when on thyroid meds. Also helps give me the ability to sweat in response to things, which I lack without it unfortunately.

Comparing things, I get a lot of the benefits from replacing cortisol with cortisone acetate but without the sides. Not all, but many. We’ll find out how much it affected my morning cortisol because that test isn’t back yet, but on the last tests it didn’t really seem to help there. The biggest benefit for me is likely one that I saw in one study, which saw a dose dependent increase in dopamine in response to different things when supplementing pregnenolone. My latest experiments with Selegiline at 2.5mg a day under the tongue in the morning seem to confirm that, which works synergistically with it.

Seems like when you supplement pregnenolone, your body is going to preferentially convert it to things and try to use it up over increasing your stores of it. At least in my case. I came into all this with PFS, so the allopregnenolone conversion likely benefits me a lot. Sucks that my blood test scores on it seem to have a cap, but I do get the benefits of it, so I’m not too sad about that. Main downside for me is that it’s technically one of the priciest things I do to take that much of it. 200mg a day was acceptable, but 400mg for me is where I prefer to be in terms of mental wellbeing and libido and being able to sweat and be more normal after PFS.

Extremely synergistic with T3 / liothyronine. If I’m on preg with little hits of that throughout the day, in as little as 18.75mcg of T3 or up to 30-40mcg T3 a day, and I have a good base of T4 built up, I think about sex pretty much all day and my dick might even get too hard. I do microdose cialis daily at 2.5-10mg, but it doesn’t do anything if I don’t have everything else in place because I can’t feel my penis as much for the blood flow to happen. I’m taking more cialis now because I had to get some weird amino version and it seems like it’s half as effective so I take more, and it was getting to be annoying cutting the pills that small.

For libido and mental well being, if my thyroid levels are looking good, pregnenolone has been one of the most effective things in my protocol. Add in some selegiline, and at least mentally I feel great. So great it takes some getting used to because I can get caught up in pretty much anything if I’m not careful. Even without the selegiline, however, things were great on most fronts, sans glycogen retention and dehydration, which I still struggle with.

Feel free to ask any questions and over time I’ll do my best to answer them because a lot of people over time have asked me about this.
What was your hydrocortisone protocol in terms of dosing and times of the day?

How is your Iodine? another sign of Iodine deficiency can be less perspiration, which is not a good thing, especially during the summer
 
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Anonymon

Active Member
What was your hydrocortisone protocol in terms of dosing and times of the day?

How is your Iodine? another sign of Iodine deficiency can be less perspiration, which is not a good thing, especially during the summer
I did different variations but they were mostly the same with different substances. I’d either take 20mg of hydrocortisone or 25mg of cortisone acetate per day, divided into the smallest doses I could make (1/8 a tablet as I recall), beginning before I woke up around 6ish when I’d get up to pee, then when I woke up, then every hour after that until I took it all. I did all HC, all CA, and a 50/50 mix of both once. HC mostly sucks and I hate everything about it. CA was very decent. I tried a little more of both and that didn’t really help any. The peak benefit with CA was actually pretty low, around 12.5mg. I got the most out of being on CA when I’d have MCT oil that seemingly helped activate it where it needed to be and I’d be wonderfully hydrated.

I’m pretty sure I had that tested at least a couple of times and it looked okay. I tried experimenting with high dose iodine and moderate dose and avoiding iodine. High dose had me feeling like I do when I start T3 the next day, then quickly seems to taper down and I feel worse. Moderate dose did nothing. Avoiding it did nothing. Might try it again I guess with everything I’m on now to see what happens as it’s not like I don’t still have some.

For me, not sweating is usually tied to one of two things based on tweaking all my levers over time: lack of muscle glycogen (For me anyway, using that up seems to initiate my sweat response and if I’m painfully low on that it won’t happen. Not being able to sweat when you workout sucks.), and low dopamine (Doing anything to up that always has me sweating when you’d normally expect, like when it’s hot). Not being able to sweat really sucks because I just turn red and puffy and feel really bad and no normal doctor really believed me. I even went to a sauna once when I realized it and just sat there and felt like crap but nothing happened with my glands.
 

Gianluca

Well-Known Member
I did different variations but they were mostly the same with different substances. I’d either take 20mg of hydrocortisone or 25mg of cortisone acetate per day, divided into the smallest doses I could make (1/8 a tablet as I recall), beginning before I woke up around 6ish when I’d get up to pee, then when I woke up, then every hour after that until I took it all. I did all HC, all CA, and a 50/50 mix of both once. HC mostly sucks and I hate everything about it. CA was very decent. I tried a little more of both and that didn’t really help any. The peak benefit with CA was actually pretty low, around 12.5mg. I got the most out of being on CA when I’d have MCT oil that seemingly helped activate it where it needed to be and I’d be wonderfully hydrated.

I’m pretty sure I had that tested at least a couple of times and it looked okay. I tried experimenting with high dose iodine and moderate dose and avoiding iodine. High dose had me feeling like I do when I start T3 the next day, then quickly seems to taper down and I feel worse. Moderate dose did nothing. Avoiding it did nothing. Might try it again I guess with everything I’m on now to see what happens as it’s not like I don’t still have some.

For me, not sweating is usually tied to one of two things based on tweaking all my levers over time: lack of muscle glycogen (For me anyway, using that up seems to initiate my sweat response and if I’m painfully low on that it won’t happen. Not being able to sweat when you workout sucks.), and low dopamine (Doing anything to up that always has me sweating when you’d normally expect, like when it’s hot). Not being able to sweat really sucks because I just turn red and puffy and feel really bad and no normal doctor really believed me. I even went to a sauna once when I realized it and just sat there and felt like crap but nothing happened with my glands.
I understand. Iodine and Thyroid optimization they both help me to sweat more, but also salt. I salt my food plus I take extras salt in water, probably like over 1/2 tsp per day just with water.

I was researching this particular matter, and it may take a couple of weeks to teach the body to sweat, but once the glands are working better, perspiration will occur more easily.
 

Anonymon

Active Member
I understand. Iodine and Thyroid optimization they both help me to sweat more, but also salt. I salt my food plus I take extras salt in water, probably like over 1/2 tsp per day just with water.

I was researching this particular matter, and it may take a couple of weeks to teach the body to sweat, but once the glands are working better, perspiration will occur more easily.
Right now I keep my salt intake constant and have a very decent amount of it. In the past I got up to 1 1/4 tsp 2-3 times a day with meals when I was at my worst. When I stopped I went to the hospital. I found out at the time I needed more because my cortisol was so low and potassium so high that I started having massive issues. Even started to get the marks people with Addison’s get and had some blood vessels burst. I can handle more salt if my T4 is higher but I also ‘use up’ water in my body or something to process it and I tend to run out real quick. Right now I’m probably around 4000mg a day to 5. At the height I wouldn’t doubt I’d hit 8-10. Hell, too much salt for me actually causes erectile dysfunction now. Which is weird but I can make it happen any time within a day and it’ll go away just as quick when I stop. That only happened while on levothyroxine.

Before all this I used to have a bunch of salt and it mostly made me feel great despite needing to pee constantly and was like a secret of mine. Now it’s very context and hormone dependent. My glands all work, it’s more that they’re not being triggered I’ve found, which things like preg and selegiline help a lot with, as does CA and T4 or seemingly glandular and T4. My face gets puffier and dryer if I have less salt but I can only handle so much of it depending on where I’m at with all this.

I also developed/reopened some ulcers from all the salt I had at the height of it that now are healed but that was one thing that kicked all this off into the worst of it for me. Kidneys are wonderful according to all the metrics and tests and my last eGFR was 115. Most of my bloodwork’s actually pretty enviable.
 
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