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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Axiron: Single testosterone measurement may lead to poor dose adjustment
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<blockquote data-quote="Nelson Vergel" data-source="post: 27467" data-attributes="member: 3"><p><strong>Utility of a Single Serum Testosterone Measurement to Determine Response to Topical Testosterone Replacement in Hypogonadal Men</strong>[h=2]Current Medical Research and Opinion.Oct 2015[/b]</p><p></p><p></p><p><strong>Objective:</strong> To evaluate the utility of single serum testosterone measurements in patients receiving transdermal testosterone therapy.</p><p><strong>Research Design and Methods:</strong> Data were from an open-label, 120-day, multi-center titration trial in androgen-deficient men receiving an initial daily dose of 60 mg testosterone (testosterone topical solution 2%) applied to axillae (30 mg/axilla). Average concentration (C[SUB]avg[/SUB]) of serum testosterone (TT) was determined on days 15, 60, and 120; doses were adjusted to maintain normal C[SUB]avg[/SUB] (300-1050 ng/dL [10.4-36.4 nmol/L]). Accuracy of single serum TT measurements (2, 4, 8, 12, 16, and 20 hours post-dose) was assessed in patients with C[SUB]avg[/SUB] TT within and below (<300 ng/dL [<10.4 nmol/L]) the normal range.</p><p><strong>Clinical Trial Registration: </strong>Clinicaltrials.gov – NCT00702650</p><p><strong>Main Outcome Measure: </strong>Serum testosterone levels.</p><p><strong>Results:</strong> In patients with normal C[SUB]avg[/SUB] (n=85), 79% to 92% had serum testosterone levels within normal range 2, 4, 8, 12, 16, and 20 hours post-dose; significant effects of time post-dose single testosterone measurement accuracy (<em>P</em>=0.01) were observed: testing accuracy peaked 4 to 8 hours post-dose and tapered ∼16 hours post-dose. In 28/63 instances with low C[SUB]avg[/SUB] TT throughout the study a normal 2-hour serum TT level was observed. The average percentage (across all days) of discordant results between C[SUB]avg[/SUB] (<300 ng/dL [<10.4 nmol/L]) and single serum TT measurements (300-1050 ng/dL [10.4-36.4 nmol/L]) declined with increasing time from dose application (44% at 2 hours, 38% at 4 hours, 22% at 8 hours, 3% at 16 hours).</p><p><strong>Conclusions:</strong> Reliance on a single serum testosterone measurement to determine the need for dose adjustment of testosterone topical solution 2% may lead clinicians to change the dose unnecessarily, or alternatively, not increase the dose when necessary. The results reported here are limited to testosterone topical solution 2% and may not be applicable to other topical agents.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 27467, member: 3"] [b]Utility of a Single Serum Testosterone Measurement to Determine Response to Topical Testosterone Replacement in Hypogonadal Men[/b][h=2]Current Medical Research and Opinion.Oct 2015[/b] [B]Objective:[/B] To evaluate the utility of single serum testosterone measurements in patients receiving transdermal testosterone therapy. [B]Research Design and Methods:[/B] Data were from an open-label, 120-day, multi-center titration trial in androgen-deficient men receiving an initial daily dose of 60 mg testosterone (testosterone topical solution 2%) applied to axillae (30 mg/axilla). Average concentration (C[SUB]avg[/SUB]) of serum testosterone (TT) was determined on days 15, 60, and 120; doses were adjusted to maintain normal C[SUB]avg[/SUB] (300-1050 ng/dL [10.4-36.4 nmol/L]). Accuracy of single serum TT measurements (2, 4, 8, 12, 16, and 20 hours post-dose) was assessed in patients with C[SUB]avg[/SUB] TT within and below (<300 ng/dL [<10.4 nmol/L]) the normal range. [B]Clinical Trial Registration: [/B]Clinicaltrials.gov – NCT00702650 [B]Main Outcome Measure: [/B]Serum testosterone levels. [B]Results:[/B] In patients with normal C[SUB]avg[/SUB] (n=85), 79% to 92% had serum testosterone levels within normal range 2, 4, 8, 12, 16, and 20 hours post-dose; significant effects of time post-dose single testosterone measurement accuracy ([I]P[/I]=0.01) were observed: testing accuracy peaked 4 to 8 hours post-dose and tapered ∼16 hours post-dose. In 28/63 instances with low C[SUB]avg[/SUB] TT throughout the study a normal 2-hour serum TT level was observed. The average percentage (across all days) of discordant results between C[SUB]avg[/SUB] (<300 ng/dL [<10.4 nmol/L]) and single serum TT measurements (300-1050 ng/dL [10.4-36.4 nmol/L]) declined with increasing time from dose application (44% at 2 hours, 38% at 4 hours, 22% at 8 hours, 3% at 16 hours). [B]Conclusions:[/B] Reliance on a single serum testosterone measurement to determine the need for dose adjustment of testosterone topical solution 2% may lead clinicians to change the dose unnecessarily, or alternatively, not increase the dose when necessary. The results reported here are limited to testosterone topical solution 2% and may not be applicable to other topical agents. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Axiron: Single testosterone measurement may lead to poor dose adjustment
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