At wits end with ED problems

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TRTinNY

Member
Hi...So i have been having an endless amount of ED problems for a very long time.

Here is the stats on me:

I am 39 (40 in August)
I was a smoker until 6 weeks ago when I quit. I cheated for a few days and had 2-3 per day for about a week over a week ago because of a huge business loss but i stopped. I did this because i was afraid it might cause my ED problems and because of my hematocrit and the need for donating blood which has caused low ferritin on occasion and then i take iron and then it is too high lol
I have low SHBG (11-17)
I have low prolactin 3.5 to 3.9
I take daily 10mg cialis and anytime i know im having sex i add 100mg viagra (all generic from the pharmacy.
I am 6'2 225 in pretty good shape.
My A1C is 5.7 and my fasting glucose at times comes back in the high 90s or low 100s which makes me a barely prediabetic i guess but no doctor feels it has been an issue.
No Thyroid problems to date

I am on 52mg (26mL) Test Cyp EOD
I take 300IU HCG 2x/week
I take .05 (yes you read the right) Anastrozole every 6 days

I have never really found the sweet spot for me with E2 because it takes a week to get my results back and i feel like i play chicken and egg with it.

I use Defy Medical and just feel like i have never got this right.

I have recurring ED problems. All I want is to not have ED problems or just know if i take a daily cialis i dont have to think about it.

When i was smoking, i was not getting morning wood for a few years. A few days after i stopped smoking i started getting raging morning wood for a bit then it just stopped. For the last few days, i am having trouble keeping a hard on unless i am vigorously stimulating myself. Some days things are amazing and i take a viagra and things just work. About 2 weeks ago i had a girl over and we spontaneously fucked and the stars aligned and everything just worked. Other days i feel like no matter what i do nothing works and yes on occasion with cialis and viagra nothing works.

I feel like i am not hopeless where i need trimix or penile implants because there are days where everything is awesome. I just cannot figure out how to zoom in on whats right on those days and replicate.

Being divorced at 39, i feel like i want to fucking kill myself (not actually) at times because of this. I have a high sex drive, just need my penis to be even mostly reliable would be nice.

I dont know if i am doomed or what but i have been on TRT for a few years and i feel like it has been a failure.

Please help.
 
Defy Medical TRT clinic doctor

TLawyer

Active Member
Hi...So i have been having an endless amount of ED problems for a very long time.

Here is the stats on me:

I am 39 (40 in August)
I was a smoker until 6 weeks ago when I quit. I cheated for a few days and had 2-3 per day for about a week over a week ago because of a huge business loss but i stopped. I did this because i was afraid it might cause my ED problems and because of my hematocrit and the need for donating blood which has caused low ferritin on occasion and then i take iron and then it is too high lol
I have low SHBG (11-17)
I have low prolactin 3.5 to 3.9
I take daily 10mg cialis and anytime i know im having sex i add 100mg viagra (all generic from the pharmacy.
I am 6'2 225 in pretty good shape.
My A1C is 5.7 and my fasting glucose at times comes back in the high 90s or low 100s which makes me a barely prediabetic i guess but no doctor feels it has been an issue.
No Thyroid problems to date

I am on 52mg (26mL) Test Cyp EOD
I take 300IU HCG 2x/week
I take .05 (yes you read the right) Anastrozole every 6 days

I have never really found the sweet spot for me with E2 because it takes a week to get my results back and i feel like i play chicken and egg with it.

I use Defy Medical and just feel like i have never got this right.

I have recurring ED problems. All I want is to not have ED problems or just know if i take a daily cialis i dont have to think about it.

When i was smoking, i was not getting morning wood for a few years. A few days after i stopped smoking i started getting raging morning wood for a bit then it just stopped. For the last few days, i am having trouble keeping a hard on unless i am vigorously stimulating myself. Some days things are amazing and i take a viagra and things just work. About 2 weeks ago i had a girl over and we spontaneously fucked and the stars aligned and everything just worked. Other days i feel like no matter what i do nothing works and yes on occasion with cialis and viagra nothing works.

I feel like i am not hopeless where i need trimix or penile implants because there are days where everything is awesome. I just cannot figure out how to zoom in on whats right on those days and replicate.

Being divorced at 39, i feel like i want to fucking kill myself (not actually) at times because of this. I have a high sex drive, just need my penis to be even mostly reliable would be nice.

I dont know if i am doomed or what but i have been on TRT for a few years and i feel like it has been a failure.

Please help.
You should post your complete labs for the most useful advice.
 

madman

Super Moderator
Hi...So i have been having an endless amount of ED problems for a very long time.

Here is the stats on me:

I am 39 (40 in August)
I was a smoker until 6 weeks ago when I quit. I cheated for a few days and had 2-3 per day for about a week over a week ago because of a huge business loss but i stopped. I did this because i was afraid it might cause my ED problems and because of my hematocrit and the need for donating blood which has caused low ferritin on occasion and then i take iron and then it is too high lol
I have low SHBG (11-17)
I have low prolactin 3.5 to 3.9
I take daily 10mg cialis and anytime i know im having sex i add 100mg viagra (all generic from the pharmacy.
I am 6'2 225 in pretty good shape.
My A1C is 5.7 and my fasting glucose at times comes back in the high 90s or low 100s which makes me a barely prediabetic i guess but no doctor feels it has been an issue.
No Thyroid problems to date

I am on 52mg (26mL) Test Cyp EOD
I take 300IU HCG 2x/week
I take .05 (yes you read the right) Anastrozole every 6 days

I have never really found the sweet spot for me with E2 because it takes a week to get my results back and i feel like i play chicken and egg with it.

I use Defy Medical and just feel like i have never got this right.

I have recurring ED problems. All I want is to not have ED problems or just know if i take a daily cialis i dont have to think about it.

When i was smoking, i was not getting morning wood for a few years. A few days after i stopped smoking i started getting raging morning wood for a bit then it just stopped. For the last few days, i am having trouble keeping a hard on unless i am vigorously stimulating myself. Some days things are amazing and i take a viagra and things just work. About 2 weeks ago i had a girl over and we spontaneously fucked and the stars aligned and everything just worked. Other days i feel like no matter what i do nothing works and yes on occasion with cialis and viagra nothing works.

I feel like i am not hopeless where i need trimix or penile implants because there are days where everything is awesome. I just cannot figure out how to zoom in on whats right on those days and replicate.

Being divorced at 39, i feel like i want to fucking kill myself (not actually) at times because of this. I have a high sex drive, just need my penis to be even mostly reliable would be nice.

I dont know if i am doomed or what but i have been on TRT for a few years and i feel like it has been a failure.

Please help.

You have been at this since 2017.

Why are you still running higher doses of T with a low SHBG?

At one time you were even injecting daily 26-30mg.

Look at how high your FT and free e2 levels were at on some of your previous protocols and that was with less than stellar TT levels.


Screenshot (1600).png



With a TT 575 ng/dL look at how high your FT levels are and bet your free e2 was through the roof.
Screenshot (1601).png


These are your FT levels using the most accurate assay Equilibrium Dialysis.
 
Last edited:

madman

Super Moderator
Look how absurdly high your FT levels are at with a TT 1100 ng/dL and that is not even using an accurate assay as it was the direct immunoassay.

Screenshot (1602).png
 

madman

Super Moderator
So do you think this has a direct correlation with my issues?

Your current protocol is 52mg EOD.

Who knows where that puts your TT/FT/e2 levels as you did not post labs.

Having low SHBG and running to high FT would have your free e2 through the roof.
 

TRTinNY

Member
This was in December....Just got labs on Friday but waiting for results. This was the morning of an injection. I dont remember if i was daily or eod that time.
 

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TRTinNY

Member
Your current protocol is 52mg EOD.

Who knows where that puts your TT/FT/e2 levels as you did not post labs.

Having low SHBG and running to high FT would have your free e2 through the roof.
That didnt answer what i was asking though but maybe the labs from December would help otherwise ill have the latest ones by the end of the week.
 

madman

Super Moderator
That didnt answer what i was asking though but maybe the labs from December would help otherwise ill have the latest ones by the end of the week.

For someone with low SHBG your FT is too high hence your high free e2 let alone RBCs/hemoglobin/hematocrit and these are trough levels?
 

TRTinNY

Member
For someone with low SHBG your FT is too high hence your high free e2 let alone RBCs/hemoglobin/hematocrit and these are trough levels?
These are not trough levels...i believe i was doing daily so isnt every day a peak or trough? I believe was after my morning injection if thats your questions.
 

madman

Super Moderator
These are not trough levels...i believe i was doing daily so isnt every day a peak or trough? I believe was after my morning injection if thats your questions.

Even if it was daily your FT levels are very high double the top end.

No wonder you are struggling with e2 and elevated RBCs/hemoglobin/hematocrit.
 

TRTinNY

Member
Even if it was daily your FT levels are very high double the top end.

No wonder you are struggling with e2 and elevated RBCs/hemoglobin/hematocrit.
So I guess my question is number one what should I be doing and number two do you think this correlates to all the ED problems that I have. I had ED problems before I went on trt but I was also 50 60 pounds heavier.
 

madman

Super Moderator
So I guess my question is number one what should I be doing and number two do you think this correlates to all the ED problems that I have. I had ED problems before I went on trt but I was also 50 60 pounds heavier.

Wait on your new labs to see where your levels sit on your current protocol.

I will pm you when I have time.
 

TRTinNY

Member
Wait on your new labs to see where your levels sit on your current protocol.

I will pm you when I have time.
I took anastrozole the night before the labs. Thinking about getting another set tomorrow for just e2 to see where I'm at a few days later.
 

fifty

Well-Known Member
I don't understand the TRT treatment that increases a guy's freeT by a factor of ~4x.

"Sir, your Free T is 70. Let's try a protocol that takes you to 350 at trough"...
 

TLawyer

Active Member
Even if it was daily your FT levels are very high double the top end.

No wonder you are struggling with e2 and elevated RBCs/hemoglobin/hematocrit.
I will say that I am low SHBG as well, and my protocol had my max TT at 1,500 and trough at maybe 750 (combination of daily injections and daily cream application). I don't remember where my Free TT and E2 was landing, but I will say that I think the protocol had me too high. I have felt better after stopping and having my levels drop. I may go back on depending on where I land, but definitely am going to shoot for a max of maybe 700 or so and obviously a lower trough.
 
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