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<blockquote data-quote="edvedder" data-source="post: 102767" data-attributes="member: 18021"><p><strong>Managing high Free T with low-normal SHBG</strong></p><p></p><p>Hi Dr Rand, Thank you to both you and excelmale for providing this forum to interact with you. I was hoping you could provide some guidelines on optimizing FT/E2.</p><p></p><p>i've been on a hormonal roller coaster after having started TRT recently with T Cyp (80mg * 2x) & Hcg with no AI. After the initial honeymoon of 2 weeks, I ended up bloated and puffy after 8 weeks with very high E2. Was prescribed anastrazole, over did it and crashed e2 quickly. Then tried a short protocol of 70 mg twice a week with 0.25 mg anastrazole twice a week and no Hcg. This was for just 2 weeks as I wanted to measure shbg and sensitive E2 instead of ECLIA and Free T which I hadn't done earlier. This resulted in: T=1090 ng/dL, FT=31.8 pg/mL, E2 sensitive=25, Shbg=20.8 nmol/L. </p><p></p><p>I was told by a doc that the high Free T coupled with the low-normal Shbg means that I'm likely just peeing it out and that I should reduce T to 50mg 2x/wk with potentially no AI. I wanted to get another opinion before embarking on this new experiment as I do not 'feel' much when I go below a total of 130 mg/wk. Would you be able to offer some guidance on what a high Free T and low normal Shbg mean?</p><p></p><p>Thanks !</p></blockquote><p></p>
[QUOTE="edvedder, post: 102767, member: 18021"] [b]Managing high Free T with low-normal SHBG[/b] Hi Dr Rand, Thank you to both you and excelmale for providing this forum to interact with you. I was hoping you could provide some guidelines on optimizing FT/E2. i've been on a hormonal roller coaster after having started TRT recently with T Cyp (80mg * 2x) & Hcg with no AI. After the initial honeymoon of 2 weeks, I ended up bloated and puffy after 8 weeks with very high E2. Was prescribed anastrazole, over did it and crashed e2 quickly. Then tried a short protocol of 70 mg twice a week with 0.25 mg anastrazole twice a week and no Hcg. This was for just 2 weeks as I wanted to measure shbg and sensitive E2 instead of ECLIA and Free T which I hadn't done earlier. This resulted in: T=1090 ng/dL, FT=31.8 pg/mL, E2 sensitive=25, Shbg=20.8 nmol/L. I was told by a doc that the high Free T coupled with the low-normal Shbg means that I'm likely just peeing it out and that I should reduce T to 50mg 2x/wk with potentially no AI. I wanted to get another opinion before embarking on this new experiment as I do not 'feel' much when I go below a total of 130 mg/wk. Would you be able to offer some guidance on what a high Free T and low normal Shbg mean? Thanks ! [/QUOTE]
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