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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
anyone with experience using mesterolone (proviron) to combat SHBG rise from clomid?
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<blockquote data-quote="Cataceous" data-source="post: 244256" data-attributes="member: 38109"><p>The body is basically regulating for its desired level of free testosterone. Sometimes this "set point" is off by enough to cause problems—secondary hypogonadism being a very common example. When this occurs there is no other compensatory mechanism. The HPTA is responsible for the regulation; if it thinks there's enough free testosterone then additional production is suppressed. My point above is that SHBG—not a <a href="https://en.wikipedia.org/wiki/Sex_hormone" target="_blank">sex hormone</a>—does not have a significant interaction with this regulatory process. You could halve your SHBG and find that free testosterone has not changed at the new equilibrium. Conventional wisdom says that free testosterone should increase. But this would apply only if you could force total testosterone to be constant. In reality free testosterone is maintained and total testosterone is reduced. So to reiterate: lowering SHBG in isolation does not improve free testosterone.</p><p></p><p>As an aside, while SHBG doesn't drive the free hormones, the free hormones do drive SHBG. Androgens tend to reduce SHBG production, while estrogens tend to increase it.</p><p></p><p>In my opinion the safest option for increasing free testosterone is with short acting products, such as testosterone nasal gel or troches. With this "TRT-lite" the HPTA can continue to function—unlike with TRT— and you're not exposed to the possible risks in long-term tampering with estrogenic activity, which you have with SERMs and AIs.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 244256, member: 38109"] The body is basically regulating for its desired level of free testosterone. Sometimes this "set point" is off by enough to cause problems—secondary hypogonadism being a very common example. When this occurs there is no other compensatory mechanism. The HPTA is responsible for the regulation; if it thinks there's enough free testosterone then additional production is suppressed. My point above is that SHBG—not a [URL='https://en.wikipedia.org/wiki/Sex_hormone']sex hormone[/URL]—does not have a significant interaction with this regulatory process. You could halve your SHBG and find that free testosterone has not changed at the new equilibrium. Conventional wisdom says that free testosterone should increase. But this would apply only if you could force total testosterone to be constant. In reality free testosterone is maintained and total testosterone is reduced. So to reiterate: lowering SHBG in isolation does not improve free testosterone. As an aside, while SHBG doesn't drive the free hormones, the free hormones do drive SHBG. Androgens tend to reduce SHBG production, while estrogens tend to increase it. In my opinion the safest option for increasing free testosterone is with short acting products, such as testosterone nasal gel or troches. With this "TRT-lite" the HPTA can continue to function—unlike with TRT— and you're not exposed to the possible risks in long-term tampering with estrogenic activity, which you have with SERMs and AIs. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
anyone with experience using mesterolone (proviron) to combat SHBG rise from clomid?
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