ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Anyone tried testosterone base (no ester)?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 184589" data-attributes="member: 13851"><p><span style="color: rgb(184, 49, 47)">But is there something special about doing it three times with the nasal gel? Maybe in the Natesto product development phase they experimented with different frequencies?</span></p><p></p><p>I think with multiple peaks (2-3x daily) it would more effective and you would reap the overall beneficial effects regarding (energy/mood/libido/erectile function/body composition).</p><p></p><p>They state that testosterone levels or symptoms are used to guide titration decisions between either twice daily or three times a day doses used to restore testosterone levels to the normal range.</p><p></p><p>If dosing once daily was truly optimal there would be no need for 2-3 times/day application</p><p></p><p></p><p><span style="color: rgb(44, 130, 201)"><em>*Based on the data, Acerus believes that the mechanism of action of NATESTO® is unique whereby <u><strong>the peaks in testosterone generated by NATESTO® dosing provide efficacy and improvement of symptoms</strong></u>, while the time between doses (4-8 hours) allows for the maintenance of testicular testosterone production and sperm production. </em></span></p><p><em></em></p><p><em><span style="color: rgb(44, 130, 201)">*The 24-hour pharmacokinetic profile of testosterone for patients on TNG treatment has <strong>t</strong><u><strong>wo or three discrete peaks (“pulses”) of testosterone</strong></u> provoked by LH secretions that occur on average every 2 hours. <u><strong>A maximal peak of testosterone appears at about 1h (Tmax) followed by a return to endogenous, pre-dose levels, 4-6 hours later (t1/2 ~1h)</strong></u><strong>.</strong> </span></em></p><p><em><span style="color: rgb(44, 130, 201)"></span></em></p><p><em><span style="color: rgb(44, 130, 201)">*Natesto, a testosterone-based nasal gel, is self-administered three times per day. Approximately 40 minutes after administration, testosterone levels return to normal, although <u><strong>Natesto’s half-life is widely variable, between 10 and 100 minutes</strong></u><strong>.</strong> </span></em></p><p><em></em></p><p><em></em></p><p></p><p></p><p><span style="color: rgb(184, 49, 47)">Are there any references for the half-life of testosterone in oil? What if it is hours instead of minutes? If so then a single morning injection would somewhat approximate a natural rhythm. </span></p><p></p><p>Not that I have come across for an oil-based unesterified T and looking through the studies done using esterified T I find it hard to believe that the carrier oil would have any impact on the delaying the absorption rate to any significant degree.</p><p></p><p>Let alone the volume of oil-injected using such a low daily dose (100mg/ml strength-based T) would be a measly 10 units/.10 ml</p><p></p><p><em><strong><span style="color: rgb(44, 130, 201)">*The pharmacokinetics and pharmacodynamics of androgen esters are therefore primarily determined by <u>ester side-chain length, the volume of oil vehicle, and site of injection via hydrophobic physicochemical partitioning of the androgen ester between the hydrophobic oil vehicle and the aqueous extracellular fluid</u>.</span></strong></em></p><p></p><p>The half-life of unmodified T is 10 min.</p><p></p><p>Endogenous testosterone secretion is likewise pulsatile and diurnal, with the highest plasma concentrations occurring at about 8 A.M. and the lowest at about 8 P.M.</p><p></p><p></p><p></p><p></p><p><span style="color: rgb(184, 49, 47)">Natural men do experience "hypogonadal" testosterone levels at their troughs.</span></p><p></p><p>Indeed!</p><p></p><p>Many healthy men, considered to be eugonadal, do have testosterone levels in the hypogonadal range during different times during the day.</p><p></p><p>The main difference is these men have a healthy functioning hpta let alone are not experiencing any low-t symptoms.</p></blockquote><p></p>
[QUOTE="madman, post: 184589, member: 13851"] [COLOR=rgb(184, 49, 47)]But is there something special about doing it three times with the nasal gel? Maybe in the Natesto product development phase they experimented with different frequencies?[/COLOR] I think with multiple peaks (2-3x daily) it would more effective and you would reap the overall beneficial effects regarding (energy/mood/libido/erectile function/body composition). They state that testosterone levels or symptoms are used to guide titration decisions between either twice daily or three times a day doses used to restore testosterone levels to the normal range. If dosing once daily was truly optimal there would be no need for 2-3 times/day application [COLOR=rgb(44, 130, 201)][I]*Based on the data, Acerus believes that the mechanism of action of NATESTO® is unique whereby [U][B]the peaks in testosterone generated by NATESTO® dosing provide efficacy and improvement of symptoms[/B][/U], while the time between doses (4-8 hours) allows for the maintenance of testicular testosterone production and sperm production. [/I][/COLOR] [I] [COLOR=rgb(44, 130, 201)]*The 24-hour pharmacokinetic profile of testosterone for patients on TNG treatment has [B]t[/B][U][B]wo or three discrete peaks (“pulses”) of testosterone[/B][/U] provoked by LH secretions that occur on average every 2 hours. [U][B]A maximal peak of testosterone appears at about 1h (Tmax) followed by a return to endogenous, pre-dose levels, 4-6 hours later (t1/2 ~1h)[/B][/U][B].[/B] *Natesto, a testosterone-based nasal gel, is self-administered three times per day. Approximately 40 minutes after administration, testosterone levels return to normal, although [U][B]Natesto’s half-life is widely variable, between 10 and 100 minutes[/B][/U][B].[/B] [/COLOR] [/I] [COLOR=rgb(184, 49, 47)]Are there any references for the half-life of testosterone in oil? What if it is hours instead of minutes? If so then a single morning injection would somewhat approximate a natural rhythm. [/COLOR] Not that I have come across for an oil-based unesterified T and looking through the studies done using esterified T I find it hard to believe that the carrier oil would have any impact on the delaying the absorption rate to any significant degree. Let alone the volume of oil-injected using such a low daily dose (100mg/ml strength-based T) would be a measly 10 units/.10 ml [I][B][COLOR=rgb(44, 130, 201)]*The pharmacokinetics and pharmacodynamics of androgen esters are therefore primarily determined by [U]ester side-chain length, the volume of oil vehicle, and site of injection via hydrophobic physicochemical partitioning of the androgen ester between the hydrophobic oil vehicle and the aqueous extracellular fluid[/U].[/COLOR][/B][/I] The half-life of unmodified T is 10 min. Endogenous testosterone secretion is likewise pulsatile and diurnal, with the highest plasma concentrations occurring at about 8 A.M. and the lowest at about 8 P.M. [COLOR=rgb(184, 49, 47)]Natural men do experience "hypogonadal" testosterone levels at their troughs.[/COLOR] Indeed! Many healthy men, considered to be eugonadal, do have testosterone levels in the hypogonadal range during different times during the day. The main difference is these men have a healthy functioning hpta let alone are not experiencing any low-t symptoms. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Anyone tried testosterone base (no ester)?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top