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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Another clue as to why TSH doesn’t suppress with thyroid replacement therapy
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<blockquote data-quote="mcs" data-source="post: 212406" data-attributes="member: 12"><p>In my case, FT3/FT4 levels are within range (upper limit of FT3) but the pituitary hormone TSH has not been responding to thyroid replacement as I <a href="https://www.excelmale.com/forum/threads/dessicated-thyroid-continues-having-zero-effect-on-tsh-elevated-ft3-normal-ft4.24360/#post-211691" target="_blank">previously posted </a>on.</p><p></p><p>More investigation reveals that I carry the <a href="https://pubmed.ncbi.nlm.nih.gov/19190113/" target="_blank">Thr92AlaD2 variant</a> which predisposes me to a T4-T3 conversion defect (+/+ [C/C] for this SNP) via decreased DIO2 enzyme. This may be why some patients seem to fail T4 monotherapy. There may also be as-yet unknown thyroid hormone resistance selective pituitary variants in my genome that could be why my TSH hasn't suppressed on meds. </p><p></p><p>Combination (T4/T3) therapy is warranted, but at <em>what ratio</em>? NDT has a 4:1 T4 to T3 ratio and there is some dispute as to whether that is an optimal level for functioning (some say too much T3), as research suggests there is a <a href="https://thyroidpatients.ca/2019/05/22/the-two-t4-t3-ratios-that-confine-thyroid-therapy/" target="_blank">wide variance </a>in the ratio in humans.</p><p></p><p>Some people have dropped the dose of NDT and added T4 to adjust the ratio to a tolerable level. Lots of tweaking involved.</p><p></p><p><strong>Bottom line:</strong> In addition to everything else discussed here, it would seem that <a href="https://www.geneticlifehacks.com/thyroid-issues-and-genetics/" target="_blank">individual thyroid genetics </a>need to be taken into account as well.</p></blockquote><p></p>
[QUOTE="mcs, post: 212406, member: 12"] In my case, FT3/FT4 levels are within range (upper limit of FT3) but the pituitary hormone TSH has not been responding to thyroid replacement as I [URL='https://www.excelmale.com/forum/threads/dessicated-thyroid-continues-having-zero-effect-on-tsh-elevated-ft3-normal-ft4.24360/#post-211691']previously posted [/URL]on. More investigation reveals that I carry the [URL='https://pubmed.ncbi.nlm.nih.gov/19190113/']Thr92AlaD2 variant[/URL] which predisposes me to a T4-T3 conversion defect (+/+ [C/C] for this SNP) via decreased DIO2 enzyme. This may be why some patients seem to fail T4 monotherapy. There may also be as-yet unknown thyroid hormone resistance selective pituitary variants in my genome that could be why my TSH hasn't suppressed on meds. Combination (T4/T3) therapy is warranted, but at [I]what ratio[/I]? NDT has a 4:1 T4 to T3 ratio and there is some dispute as to whether that is an optimal level for functioning (some say too much T3), as research suggests there is a [URL='https://thyroidpatients.ca/2019/05/22/the-two-t4-t3-ratios-that-confine-thyroid-therapy/']wide variance [/URL]in the ratio in humans. Some people have dropped the dose of NDT and added T4 to adjust the ratio to a tolerable level. Lots of tweaking involved. [B]Bottom line:[/B] In addition to everything else discussed here, it would seem that [URL='https://www.geneticlifehacks.com/thyroid-issues-and-genetics/']individual thyroid genetics [/URL]need to be taken into account as well. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Another clue as to why TSH doesn’t suppress with thyroid replacement therapy
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