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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Androgens and Non-Genomic vascular responses in hypertension
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<blockquote data-quote="madman" data-source="post: 229738" data-attributes="member: 13851"><p><strong>Fig. 2. <u>Differences of sex steroid mechanisms of action. Non-genomic mechanism (red arrow)</u>: androgen responses occur through membranes that are independent of the ligand-dependent transactivation function of nuclear receptors, they are rapid onset (seconds to minutes), short duration, and not modified by inhibitors of transcription or protein synthesis. <u>Genomic effects</u> (<u>blue arrow</u>): the androgen receptor signaling pathway for genomic action signaling involves androgens crossing the plasma membrane, entering the cytoplasm, and binding to the androgen receptor (androgen-receptor complex), resulting in the translocation of the complex to the nucleus where it dimerizes and binds to the androgen response element for modulating gene transcription, and leads to protein synthesis creating a biological response which is slower onset (minutes to days), and longer duration.</strong></p><p><strong>[ATTACH=full]24458[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 229738, member: 13851"] [B]Fig. 2. [U]Differences of sex steroid mechanisms of action. Non-genomic mechanism (red arrow)[/U]: androgen responses occur through membranes that are independent of the ligand-dependent transactivation function of nuclear receptors, they are rapid onset (seconds to minutes), short duration, and not modified by inhibitors of transcription or protein synthesis. [U]Genomic effects[/U] ([U]blue arrow[/U]): the androgen receptor signaling pathway for genomic action signaling involves androgens crossing the plasma membrane, entering the cytoplasm, and binding to the androgen receptor (androgen-receptor complex), resulting in the translocation of the complex to the nucleus where it dimerizes and binds to the androgen response element for modulating gene transcription, and leads to protein synthesis creating a biological response which is slower onset (minutes to days), and longer duration. [ATTACH type="full"]24458[/ATTACH][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Androgens and Non-Genomic vascular responses in hypertension
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