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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Allosterically coupled multi-site binding of T to human serum albumin
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<blockquote data-quote="madman" data-source="post: 191318" data-attributes="member: 13851"><p><strong>EAM <span style="color: rgb(184, 49, 47)">(cFTZ) </span><span style="color: rgb(0, 0, 0)">SHBG: T binding</span></strong></p><p><strong></strong></p><p><strong>The relation between Percent FT with Total Testosterone and SHBG. <span style="color: rgb(44, 130, 201)"><u>Intra-dimer complex allostery suggests that SHBG can regulate FT fraction over a wide range of total testosterone concentrations without getting saturated</u>.</span></strong><span style="color: rgb(184, 49, 47)"> <strong><u>Indeed, it was found that percent FT calculated using the new model changed very modestly over a wide range of total testosterone concentrations</u>.</strong></span> <strong><span style="color: rgb(26, 188, 156)">In contrast, Vermeulen's equation suggests a negative relation between percent FT and total testosterone.</span></strong> <span style="color: rgb(184, 49, 47)"><strong><u>Furthermore, as SHBG concentrations increase, the percent FT calculated using our new model shows only a modest decline</u></strong> </span><span style="color: rgb(26, 188, 156)"><strong><u>in contrast to the marked decline in percent FT calculated using Vermeulen's equation</u>.</strong></span></p><p></p><p></p><p></p><p></p><p><strong>The new dynamic model leads to the reconsideration of several dogmas related to testosterone's binding to SHBG and has important physiologic and clinical implications. <span style="color: rgb(184, 49, 47)">First, the fraction of circulating testosterone which is free is substantially greater (2.9±0.4%)</span></strong> <strong><span style="color: rgb(184, 49, 47)">than has been generally assumed</span> <span style="color: rgb(26, 188, 156)">(% cFTV 1.5±0.4%)</span></strong>.<strong> <span style="color: rgb(184, 49, 47)"><u>Second, percent FT is not significantly related to total testosterone over a wide range of total testosterone concentrations</u>. <u>However, the percent FT declines as SHBG concentrations increase</u>, </span></strong><span style="color: rgb(26, 188, 156)"><strong><u>although it does not decline as precipitously as predicted by Vermeulen's model</u>.</strong></span> <span style="color: rgb(44, 130, 201)"><strong><u>Due to the allostery between the two binding sites, SHBG is able to regulate FT levels in a much larger dynamic range</u>.</strong> </span></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong>*</strong><span style="color: rgb(44, 130, 201)"><strong><u>Intra-dimer complex allostery suggests that</u></strong></span><span style="color: rgb(250, 197, 28)"><strong><u> SHBG can regulate FT fraction over a wide range of total testosterone concentrations without getting saturated</u>.</strong></span> </p><p></p><p><strong>*<span style="color: rgb(44, 130, 201)"><u>Indeed, it was found that percent FT calculated using the new model </u></span><span style="color: rgb(250, 197, 28)"><u>changed very modestly over a wide range of total testosterone concentrations</u>.</span></strong></p><p><strong></strong></p><p><strong>*<span style="color: rgb(44, 130, 201)"><u>Due to the allostery between the two binding sites,</u></span><span style="color: rgb(250, 197, 28)"><u> SHBG is able to regulate FT levels in a much larger dynamic range</u>.</span></strong></p></blockquote><p></p>
[QUOTE="madman, post: 191318, member: 13851"] [B]EAM [COLOR=rgb(184, 49, 47)](cFTZ) [/COLOR][COLOR=rgb(0, 0, 0)]SHBG: T binding[/COLOR] The relation between Percent FT with Total Testosterone and SHBG. [COLOR=rgb(44, 130, 201)][U]Intra-dimer complex allostery suggests that SHBG can regulate FT fraction over a wide range of total testosterone concentrations without getting saturated[/U].[/COLOR][/B][COLOR=rgb(184, 49, 47)] [B][U]Indeed, it was found that percent FT calculated using the new model changed very modestly over a wide range of total testosterone concentrations[/U].[/B][/COLOR] [B][COLOR=rgb(26, 188, 156)]In contrast, Vermeulen's equation suggests a negative relation between percent FT and total testosterone.[/COLOR][/B] [COLOR=rgb(184, 49, 47)][B][U]Furthermore, as SHBG concentrations increase, the percent FT calculated using our new model shows only a modest decline[/U][/B] [/COLOR][COLOR=rgb(26, 188, 156)][B][U]in contrast to the marked decline in percent FT calculated using Vermeulen's equation[/U].[/B][/COLOR] [B]The new dynamic model leads to the reconsideration of several dogmas related to testosterone's binding to SHBG and has important physiologic and clinical implications. [COLOR=rgb(184, 49, 47)]First, the fraction of circulating testosterone which is free is substantially greater (2.9±0.4%)[/COLOR][/B][COLOR=rgb(184, 49, 47)] [/COLOR][B][COLOR=rgb(184, 49, 47)]than has been generally assumed[/COLOR] [COLOR=rgb(26, 188, 156)](% cFTV 1.5±0.4%)[/COLOR][/B].[B] [COLOR=rgb(184, 49, 47)][U]Second, percent FT is not significantly related to total testosterone over a wide range of total testosterone concentrations[/U]. [U]However, the percent FT declines as SHBG concentrations increase[/U], [/COLOR][/B][COLOR=rgb(26, 188, 156)][B][U]although it does not decline as precipitously as predicted by Vermeulen's model[/U].[/B][/COLOR][COLOR=rgb(184, 49, 47)][B] [/B][/COLOR][COLOR=rgb(44, 130, 201)][B][U]Due to the allostery between the two binding sites, SHBG is able to regulate FT levels in a much larger dynamic range[/U].[/B] [/COLOR] [B]*[/B][COLOR=rgb(44, 130, 201)][B][U]Intra-dimer complex allostery suggests that[/U][/B][/COLOR][COLOR=rgb(250, 197, 28)][B][U] SHBG can regulate FT fraction over a wide range of total testosterone concentrations without getting saturated[/U].[/B][/COLOR][COLOR=rgb(44, 130, 201)] [/COLOR] [B]*[COLOR=rgb(44, 130, 201)][U]Indeed, it was found that percent FT calculated using the new model [/U][/COLOR][COLOR=rgb(250, 197, 28)][U]changed very modestly over a wide range of total testosterone concentrations[/U].[/COLOR] *[COLOR=rgb(44, 130, 201)][U]Due to the allostery between the two binding sites,[/U][/COLOR][COLOR=rgb(250, 197, 28)][U] SHBG is able to regulate FT levels in a much larger dynamic range[/U].[/COLOR][/B][COLOR=rgb(250, 197, 28)] [/COLOR] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Allosterically coupled multi-site binding of T to human serum albumin
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