ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Allosterically coupled multi-site binding of T to human serum albumin
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 190010" data-attributes="member: 13851"><p><span style="color: rgb(0, 0, 0)"><strong>Figure 7: </strong></span><span style="color: rgb(184, 49, 47)"><strong>Spatial rearrangements in HSA structure upon testosterone binding and principal component analysis (PCA) for inter-domain dynamics.</strong></span> <span style="color: rgb(44, 130, 201)"><strong>(7A)</strong></span><span style="color: rgb(0, 0, 0)"><strong> Specific movement of R348 hydrogen-bonded with OA </strong></span><span style="color: rgb(26, 188, 156)"><strong>(green)</strong></span><span style="color: rgb(0, 0, 0)"><strong> to HSA. A superposition of crystal structure </strong></span><span style="color: rgb(250, 197, 28)"><strong>(PDB ID: 1GNI, yellow)</strong></span><span style="color: rgb(0, 0, 0)"><strong> and MD snapshot of HSA:6OA: T </strong></span><span style="color: rgb(184, 49, 47)"><strong>(red)</strong></span><span style="color: rgb(0, 0, 0)"><strong>. testosterone </strong></span><span style="color: rgb(235, 107, 86)"><strong>(pink)</strong></span><span style="color: rgb(0, 0, 0)"><strong> is unable to form a hydrogen bond due to its compact, smaller structure. This enables domain IIB to move toward domain III, leading to a decrease in affinity for OA at site 6. </strong></span><span style="color: rgb(184, 49, 47)"><strong>(7B)</strong></span><span style="color: rgb(0, 0, 0)"><strong> PCA and PCA vector field representation of HSA only </strong></span><span style="color: rgb(184, 49, 47)"><strong>(with fatty acid site 3 occupied by testosterone and remaining sites with OA)</strong></span><span style="color: rgb(0, 0, 0)"><strong>. This depicts the primary atomic motions in HSA upon testosterone binding to site 3. </strong></span></p><p>[ATTACH=full]11391[/ATTACH]</p><p>[ATTACH=full]11392[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 190010, member: 13851"] [COLOR=rgb(0, 0, 0)][B]Figure 7: [/B][/COLOR][COLOR=rgb(184, 49, 47)][B]Spatial rearrangements in HSA structure upon testosterone binding and principal component analysis (PCA) for inter-domain dynamics.[/B][/COLOR][COLOR=rgb(0, 0, 0)][B] [/B][/COLOR][COLOR=rgb(44, 130, 201)][B](7A)[/B][/COLOR][COLOR=rgb(0, 0, 0)][B] Specific movement of R348 hydrogen-bonded with OA [/B][/COLOR][COLOR=rgb(26, 188, 156)][B](green)[/B][/COLOR][COLOR=rgb(0, 0, 0)][B] to HSA. A superposition of crystal structure [/B][/COLOR][COLOR=rgb(250, 197, 28)][B](PDB ID: 1GNI, yellow)[/B][/COLOR][COLOR=rgb(0, 0, 0)][B] and MD snapshot of HSA:6OA: T [/B][/COLOR][COLOR=rgb(184, 49, 47)][B](red)[/B][/COLOR][COLOR=rgb(0, 0, 0)][B]. testosterone [/B][/COLOR][COLOR=rgb(235, 107, 86)][B](pink)[/B][/COLOR][COLOR=rgb(0, 0, 0)][B] is unable to form a hydrogen bond due to its compact, smaller structure. This enables domain IIB to move toward domain III, leading to a decrease in affinity for OA at site 6. [/B][/COLOR][COLOR=rgb(184, 49, 47)][B](7B)[/B][/COLOR][COLOR=rgb(0, 0, 0)][B] PCA and PCA vector field representation of HSA only [/B][/COLOR][COLOR=rgb(184, 49, 47)][B](with fatty acid site 3 occupied by testosterone and remaining sites with OA)[/B][/COLOR][COLOR=rgb(0, 0, 0)][B]. This depicts the primary atomic motions in HSA upon testosterone binding to site 3. [/B][/COLOR] [ATTACH type="full"]11391[/ATTACH] [ATTACH type="full"]11392[/ATTACH] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Allosterically coupled multi-site binding of T to human serum albumin
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top