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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Allosterically coupled multi-site binding of T to human serum albumin
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<blockquote data-quote="madman" data-source="post: 190003" data-attributes="member: 13851"><p><strong>Figure 5: <span style="color: rgb(184, 49, 47)">Binding of testosterone to site 3 allosterically alters the orientation of residues in site 6, disrupting the hydrogen bonding in site 6.</span> <span style="color: rgb(44, 130, 201)">5A </span>shows the presence of hydrogen bonds with the S480 residue <span style="color: rgb(184, 49, 47)">(Sites 3 and 6 in the crystal structure of HSA (PDB ID: 1GNI))</span>. <span style="color: rgb(44, 130, 201)">5B </span>shows the rearrangement of residue orientation in site 6 due to the binding of testosterone at site 3 and loss of hydrogen bond with S480 and moves away from F204. OA of HSA:7OA <span style="color: rgb(184, 49, 47)">(Panel A) </span>at site 3 is depicted in <span style="color: rgb(26, 188, 156)">green</span> and OA at site 6 is depicted in <span style="color: rgb(61, 142, 185)">cyan</span>; testosterone of HSA:6OA: T <span style="color: rgb(184, 49, 47)">(Panel B)</span> at site 3 is depicted in <span style="color: rgb(226, 80, 65)">pink</span> and OA at site 6 is shown in <span style="color: rgb(243, 121, 52)">orange </span></strong></p><p>[ATTACH=full]11382[/ATTACH]</p><p>[ATTACH=full]11383[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 190003, member: 13851"] [B]Figure 5: [COLOR=rgb(184, 49, 47)]Binding of testosterone to site 3 allosterically alters the orientation of residues in site 6, disrupting the hydrogen bonding in site 6.[/COLOR] [COLOR=rgb(44, 130, 201)]5A [/COLOR]shows the presence of hydrogen bonds with the S480 residue [COLOR=rgb(184, 49, 47)](Sites 3 and 6 in the crystal structure of HSA (PDB ID: 1GNI))[/COLOR]. [COLOR=rgb(44, 130, 201)]5B [/COLOR]shows the rearrangement of residue orientation in site 6 due to the binding of testosterone at site 3 and loss of hydrogen bond with S480 and moves away from F204. OA of HSA:7OA [COLOR=rgb(184, 49, 47)](Panel A) [/COLOR]at site 3 is depicted in [COLOR=rgb(26, 188, 156)]green[/COLOR][COLOR=rgb(65, 168, 95)] [/COLOR]and OA at site 6 is depicted in [COLOR=rgb(61, 142, 185)]cyan[/COLOR]; testosterone of HSA:6OA: T [COLOR=rgb(184, 49, 47)](Panel B)[/COLOR] at site 3 is depicted in [COLOR=rgb(226, 80, 65)]pink[/COLOR] and OA at site 6 is shown in [COLOR=rgb(243, 121, 52)]orange [/COLOR][/B] [ATTACH type="full"]11382[/ATTACH] [ATTACH type="full"]11383[/ATTACH] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Allosterically coupled multi-site binding of T to human serum albumin
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