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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Advances in stem cell research for the treatment of primary hypogonadism
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<blockquote data-quote="madman" data-source="post: 209443" data-attributes="member: 13851"><p><strong>Key points </strong></p><p></p><p><em><strong>• Primary hypogonadism is mainly treated using testosterone replacement therapy (TRT). However, TRT has adverse effects and is unsuitable for men with hypogonadism wishing to maintain fertility </strong></em></p><p><em><strong></strong></em></p><p><em><strong>• Stem-cell-based therapy, in which a cell lineage can be re-established in human bodies to produce testosterone normally, would be the ideal choice for treating primary hypogonadism </strong></em></p><p><em><strong></strong></em></p><p><em><strong>• Stem Leydig cells, mesenchymal stromal cells, pluripotent stem cells, and fibroblasts are newly discovered sources of Leydig cells </strong></em></p><p><em><strong></strong></em></p><p><em><strong>• Stem-cell-derived Leydig cells have many potential applications, including understanding the underlying mechanisms of primary hypogonadism, treating primary hypogonadism using transplantation therapy, and discovering drugs aimed at recovering Leydig cell function </strong></em></p><p><em><strong></strong></em></p><p><strong><em>• Research is needed in the applications of Leydig cells, including constructing 3D testicular organoids, promoting in vitro culture conditions of Leydig cells, and exploring the in vivo transplantation locations of Leydig cells</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 209443, member: 13851"] [B]Key points [/B] [I][B]• Primary hypogonadism is mainly treated using testosterone replacement therapy (TRT). However, TRT has adverse effects and is unsuitable for men with hypogonadism wishing to maintain fertility • Stem-cell-based therapy, in which a cell lineage can be re-established in human bodies to produce testosterone normally, would be the ideal choice for treating primary hypogonadism • Stem Leydig cells, mesenchymal stromal cells, pluripotent stem cells, and fibroblasts are newly discovered sources of Leydig cells • Stem-cell-derived Leydig cells have many potential applications, including understanding the underlying mechanisms of primary hypogonadism, treating primary hypogonadism using transplantation therapy, and discovering drugs aimed at recovering Leydig cell function [/B][/I] [B][I]• Research is needed in the applications of Leydig cells, including constructing 3D testicular organoids, promoting in vitro culture conditions of Leydig cells, and exploring the in vivo transplantation locations of Leydig cells[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Advances in stem cell research for the treatment of primary hypogonadism
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