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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Advances in stem cell research for the treatment of primary hypogonadism
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<blockquote data-quote="madman" data-source="post: 209441" data-attributes="member: 13851"><p><strong>Gonadotropin therapy </strong></p><p></p><p><em><strong>Alternative therapies to TRT, such as the administration of exogenous gonadotropins (hCG or LH) with or without FSH, can be used to restore fertility in patients with secondary hypogonadism72. <u>Administration of gonadotropins is not indicated for men with primary hypogonadism, as their Leydig cells respond weakly to gonadotropins</u>.</strong> hCG and LH share the same receptor (LHCGR) and promote the testosterone biosynthesis of Leydig cells, but hCG has a longer half-life (36h) than LH (30min), making hCG a more commonly used gonadotropin for treating secondary hypogonadism107.<strong> Notably, hCG is the only FDA-approved non-testosterone compound for the treatment of male hypogonadism108.</strong> In comparison to TRT, hCG therapy can preserve spermatogenesis. hCG is generally given by subcutaneous or intramuscular injection, with an initial dose of 1,000–1,500 IU twice or three times a week109,110.<strong> <u>FSH alone cannot reverse infertility in hypogonadal men</u>, but FSH can be given (via subcutaneous injection, 75–150 IU three times a week) to patients when hCG administration alone fails to restore spermatogenesis109. </strong>A study including 75 men diagnosed with secondary hypogonadism showed that 38 men became fathers after receiving 116 cycles of hCG therapy with an initial hCG dose of 1,500 or 2,000 IU given twice a week followed by 75 IU of FSH given three times a week if no sperm were detected following 6 months of hCG treatment110. The median concentration of sperm to achieve pregnancy was 8.0 million/ml (95% CI: 0.2–59.5 million/ml) after 2.3 years of treatment110.<strong> hCG administration is also used in combination with TRT to maintain fertility during treatment, or to re-establish fertility after TRT107, and has minimal adverse effects, except for gynaecomastia111.</strong> However, the required twice-per-week injections are inconvenient for the patients. Thus, hypogonadal men who do not seek to preserve fertility might choose alternative therapies111</em></p></blockquote><p></p>
[QUOTE="madman, post: 209441, member: 13851"] [B]Gonadotropin therapy [/B] [I][B]Alternative therapies to TRT, such as the administration of exogenous gonadotropins (hCG or LH) with or without FSH, can be used to restore fertility in patients with secondary hypogonadism72. [U]Administration of gonadotropins is not indicated for men with primary hypogonadism, as their Leydig cells respond weakly to gonadotropins[/U].[/B] hCG and LH share the same receptor (LHCGR) and promote the testosterone biosynthesis of Leydig cells, but hCG has a longer half-life (36h) than LH (30min), making hCG a more commonly used gonadotropin for treating secondary hypogonadism107.[B] Notably, hCG is the only FDA-approved non-testosterone compound for the treatment of male hypogonadism108.[/B] In comparison to TRT, hCG therapy can preserve spermatogenesis. hCG is generally given by subcutaneous or intramuscular injection, with an initial dose of 1,000–1,500 IU twice or three times a week109,110.[B] [U]FSH alone cannot reverse infertility in hypogonadal men[/U], but FSH can be given (via subcutaneous injection, 75–150 IU three times a week) to patients when hCG administration alone fails to restore spermatogenesis109. [/B]A study including 75 men diagnosed with secondary hypogonadism showed that 38 men became fathers after receiving 116 cycles of hCG therapy with an initial hCG dose of 1,500 or 2,000 IU given twice a week followed by 75 IU of FSH given three times a week if no sperm were detected following 6 months of hCG treatment110. The median concentration of sperm to achieve pregnancy was 8.0 million/ml (95% CI: 0.2–59.5 million/ml) after 2.3 years of treatment110.[B] hCG administration is also used in combination with TRT to maintain fertility during treatment, or to re-establish fertility after TRT107, and has minimal adverse effects, except for gynaecomastia111.[/B] However, the required twice-per-week injections are inconvenient for the patients. Thus, hypogonadal men who do not seek to preserve fertility might choose alternative therapies111[/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Advances in stem cell research for the treatment of primary hypogonadism
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