ACE and ARB blood pressure meds (i.e losartan) and coronavirus concern

[Marco N Cognito]

Skip to 23:33. This is troubling. Jay's guest, Anthony Jay, PhD, fails to mention the more recent contrarian argument that we've been making in which upregulation of ACE2 via ACEIs and ARBs can actually be protective and block the virus from entry (and the fact that Losartan is in clinical trials as potential treatment for COVID-19 [Losartan for Patients With COVID-19 Requiring Hospitalization - Full Text View - ClinicalTrials.gov]. He advises to just stop the meds even if BP goes up a little.

 

[GreenMachineX]

I wonder why the studies keep mentioning losartan...telmisartan does the same thing and has anti-inflammatory and PPAR activity...shouldn’t it work just as well?

 

[Marco N Cognito]

I wonder why the studies keep mentioning losartan...telmisartan does the same thing and has anti-inflammatory and PPAR activity...shouldn’t it work just as well?

Use of angiotensin receptor blockers such as Telmisartan, Losartsan in nCoV Wuhan Corona Virus infections – Novel mode of treatment

www.bmj.com

 

[Westin]

Stay off of Facebook until this is over. Way too much misinformation.

 

[GreenMachineX]

Use of angiotensin receptor blockers such as Telmisartan, Losartsan in nCoV Wuhan Corona Virus infections – Novel mode of treatment

www.bmj.com

Thanks. I have seen that one too, but I feel like I’m seeing more in general about losartan. I could be wrong though. I love this thread though.

 

[GreenMachineX]

Stay off of Facebook until this is over. Way too much misinformation.

What does Facebook have to do with ARBs and this virus? What did I miss?

 

[Westin]

It’s the main offender of misinformation. People keep forwarding this information as of they just discovered a miracle. I keep getting all this virus stuff, It’s all BS. They know but the CDC has never heard of it?

Facebook is a menace to society in my opinion.

BTW: I’m on 50mg If it a day of it. Works well.

Done venting

 

[GreenMachineX]

It’s the main offender of misinformation. People keep forwarding this information as of they just discovered a miracle. I keep getting all this virus stuff, It’s all BS. They know but the CDC has never heard of it?

Facebook is a menace to society in my opinion.

BTW: I’m on 50mg If it a day of it. Works well.

Done venting

Oh, gotcha. I’m mostly on message boards, rarely on Facebook. But I agree, mostly sensationalism and misinformation (and possibly disinformation!!!).

 

[Marco N Cognito]

Angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers in COVID-19 - The Centre for Evidence-Based Medicine

There is no evidence that ACE-1 inhibitors, e.g. enalapril and ramipril, and ARBs, such as candesartan and valsartan, may treat COVID-19.

www.cebm.net

https://www.cebm.net/wp-content/uploads/2020/03/ACEI-ARB-recommendations-BMJ-1.png

 

[Marco N Cognito]

Much of the controversy about the positive or negative effect of ARB/ACEI is based on a time confusion. The positive effect of ACE2 would only occur AFTER the SARS-CoV-2 entered into the target cells. On the opposite, BEFORE its entry, the ACE2 availability may potently increase the number of receptors for the virus spike proteins and leads to an enhanced severity of the infection. This is the conundrum I worry about. What we urgently need now is the ratio of death according to the use or not of ARB/ACEI among the patients with comorbidities (hypertension, diabetes, CVD).

 

[Marco N Cognito]

Angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers in COVID-19 - The Centre for Evidence-Based Medicine

There is no evidence that ACE-1 inhibitors, e.g. enalapril and ramipril, and ARBs, such as candesartan and valsartan, may treat COVID-19.

www.cebm.net

 

[GreenMachineX]

This is a cardiologist’s opinion on blood pressure, ACE inhibitors and COVID-19. It makes the most sense to me.

 

[Marco N Cognito]

Blood Pressure Meds Point the Way to Possible COVID-19 Treatment

There is little evidence that antihypertensive drugs worsen COVID-19, and scientists are instead exploring the idea that such medications—or their downstream effects—may actually alleviate symptoms.

www.the-scientist.com

 

[GreenMachineX]

“Findings Among the elderly (age>65) COVID-19 patients with hypertension comorbidity, the risk of COVID-19-S (severe disease) was significantly decreased in patients who took ARB drugs prior to hospitalization compared to patients who took no drugs (OR=0.343, 95% CI 0.128-0.916, p=0.025). The meta-analysis showed that ARB use has positive effects associated with morbidity and mortality of pneumonia. Interpretation Elderly (age>65) COVID-19 patients with hypertension comorbidity who are taking ARB anti-hypertension drugs may be less likely to develop severe lung disease compared to patients who take no anti-hypertension drugs.”

Anti-hypertensive Angiotensin II receptor blockers associated to mitigation of disease severity in elderly COVID-19 patients

Background The novel coronavirus (CoV) severe acute respiratory syndrome (SARS)-CoV-2 outbreak started at the end of 2019 in Wuhan, China, and spread over 100 countries. SARS-CoV-2 uses the membrane protein Angiotensin I converting enzyme 2(ACE2) as a cell entry receptor. Indeed, it was reported...

www.medrxiv.org

 

[Marco N Cognito]

Blood-pressure drugs are in the crosshairs of COVID-19 research

Scientists are baffled by how the coronavirus attacks the body - killing many patients while barely affecting others.

www.reuters.com

 

[Golfboy307]

Excellent balanced article. Thanks for posting. I am going to keep taking my 20mg Lisinopril for the time being. And social distancing!

 

[GreenMachineX]

Excellent balanced article. Thanks for posting. I am going to keep taking my 20mg Lisinopril for the time being. And social distancing!

Same here as I’m on telmisartan. I also wonder if taking these drugs causing an increase in ACE2 receptors, how long does it take for the new Receptors to go away when the drug is discontinued? Processes like that aren’t instant, correct?

 

[GreenMachineX]

Same here as I’m on telmisartan. I also wonder if taking these drugs causing an increase in ACE2 receptors, how long does it take for the new Receptors to go away when the drug is discontinued? Processes like that aren’t instant, correct?

@Nelson Vergel
Any thoughts on this?

 

[Marco N Cognito]

UPDATE FROM MEDCRAM:

 

[Golfboy307]

Thanks for posting... feeling better about this particular question.