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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
A SERM (fispemifene) increases testosterone but not sex drive
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<blockquote data-quote="Nelson Vergel" data-source="post: 35771" data-attributes="member: 3"><p>Shares of San Diego-based Apricus Biosciences were crushed this morning after the biotech reported that its experimental testosterone-boosting drug had failed both the primary and secondary endpoints in a Phase IIb study among men with secondary hypogonadism and sexual dysfunction. And the setback raises some additional issues for the entire drug class.</p><p></p><p></p><p>Researchers noted that fispemifene at 450 mg did boost testosterone among the men in the study, but failed to improve erectile function or low libido, missing out on providing a clear clinical benefit--an urgent necessity in the wake of the FDA's increased vigilance on testosterone therapies. As a result, the biotech plans to bury the program and focus on other work.</p><p></p><p>Fispemifene is a once daily orally administered selective estrogen receptor modulator (SERM) in development for multiple urological conditions in men.</p><p></p><p><a href="http://www.fiercebiotech.com/story/apricus-routed-after-punting-testosterone-drug-following-trial-flop/2016-03-28" target="_blank">http://www.fiercebiotech.com/story/apricus-routed-after-punting-testosterone-drug-following-trial-flop/2016-03-28</a></p><p></p><p>Note: I suspect the same issue with this product:</p><p></p><p></p><p><strong><a href="https://www.excelmale.com/forum/showthread.php?5735-The-FDA-sends-the-maker-of-enclomiphene-back-to-drawing-board" target="_blank">The FDA sends the maker of enclomiphene back to drawing board</a></strong></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 35771, member: 3"] Shares of San Diego-based Apricus Biosciences were crushed this morning after the biotech reported that its experimental testosterone-boosting drug had failed both the primary and secondary endpoints in a Phase IIb study among men with secondary hypogonadism and sexual dysfunction. And the setback raises some additional issues for the entire drug class. Researchers noted that fispemifene at 450 mg did boost testosterone among the men in the study, but failed to improve erectile function or low libido, missing out on providing a clear clinical benefit--an urgent necessity in the wake of the FDA's increased vigilance on testosterone therapies. As a result, the biotech plans to bury the program and focus on other work. Fispemifene is a once daily orally administered selective estrogen receptor modulator (SERM) in development for multiple urological conditions in men. [url]http://www.fiercebiotech.com/story/apricus-routed-after-punting-testosterone-drug-following-trial-flop/2016-03-28[/url] Note: I suspect the same issue with this product: [b][URL="https://www.excelmale.com/forum/showthread.php?5735-The-FDA-sends-the-maker-of-enclomiphene-back-to-drawing-board"]The FDA sends the maker of enclomiphene back to drawing board[/URL][/b] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
A SERM (fispemifene) increases testosterone but not sex drive
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