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  1. R

    What does low shbg actually mean ?

    So I don’t want the medical technical Mumbo jumbo about it’s a carrier protein and all but what I want to know is if someone has low shbg what do they feel like . Should they feel tired , not optimized , workouts suck ,low sex drive, recovery ect . Does having normal levels make you feel better ?
  2. D

    How many like/dislike effects of HCG?

    Just wondering how many guys get favorable results using HCG? (Well being, mood, libido etc. other than fertility)
  3. Z

    Letting e2 run wild

    My old dr was a dr who was all about not treating E2. He said let it go as high as you want and it won’t be a problem. Well I am seeing a new dr now and my e2 sensitive was 45. My libido has been super low, my anxiety kind of high, also my junk shrivels up to nothing along with my scrotum...
  4. T

    Feeling emotional - Estradiol at 81pg/ml with 1.5mg anastrozole per week

    I was feeling borderline tearful again yesterday and decided to test some markers, prolactin, thyroid, estradiol and cortisol. Cortisol came back slightly below medium, FT4 on the low end, FT3 right in the middle. Prolactin was fine at 3.9 ug/l. Even kinda low. Estradiol on the other hand...
  5. T

    What do you guys do to tackle mood/anxiety if anything?

    I haven't found much myself. I manage the E2 which helps. Recently I've begun taking LDN as well and all I can say is maybe it helps.. it seems to to a degree.
  6. T

    Your experiences with increasing testosterone dosage?

    This is a re-post to an extent. But what I want to hear is some of your stories on increasing testosterone. Here is mine (without much facts, just how I experienced and read it): I was taking 50mg testosterone gel and had levels at 24nmol/l or almost 700ng/dl. I increased to 100mg and...
  7. G

    Testosterone Effects on Mood

    I’m having trouble understanding something. I’ve read on here that it takes weeks to really see a difference when adjusting dose and also that it takes some length of time for testosterone deficiency induced depression to lift. But, when talking about injections every 2 weeks, apparently it’s...
  8. C

    Kisspeptin suppression under TRT: Can it affect mood and libido?

    TD;LR: Kisspeptin may affect how we act and feel. It seems plausible that a TRT-induced reduction in this hormone is a problem for some men. I’d previously asked if suppression of GnRH by TRT is a problem. The literature at least hints that it is possible. The situation with kisspeptin may be...
  9. Will Brink

    Inflammation, motivation and dopamine

    There's a fascinating connection between inflammation, dopamine, and motivation: "Why do we feel listless when we are recovering from an illness? The answer is, apparently, that low-grade chronic inflammation interferes with the dopaminergic signaling system in the brain that motivates us to do...
  10. Z

    Question on labs

    So I got my lab results today Free T-17.7 TT-797 E2-35 (roche test) SHGB 36.1 PSA-.9 I have been having some libido issues along with a little bit of mood issues. 3 weeks ago I was great. Now, kind of in the middle. Having difficulty getting erections and maintaining. Sex drive is pretty low...
  11. I

    Testosterone vs HCG when it comes to mood?

    When did you have better overall feeling? When you were on HCG or testosterone? Does your mood changes a lot when you switch those two medications? Thanks.
  12. K

    Why the Mood Stinks 5 out of 7 days?

    Hi everybody, As I have said in previous posts, my endo prescribed me 175mg of testosterone cypionate every 14 days. I instead chose to give myself my medication every 7 days after reading of the stupidity of injecting every 14 days. I also know that my dosage is probably too high for a beginner...
  13. A

    anti-depressive/mood enhancing effect of celebrex(?) Alternatives?

    Hi all, I was recently prescribed some Celebrex (celecoxib) for persistent lower back pain. I took it for about two week (200 mg/day) and it provided relief for the back pain symptoms. The last dose was 3 nights ago. During the second week while I was on celebrex, my state of mind (mood, mental...
  14. B

    Mood, libido

    Hey guys. Got a question I'm hoping you can help me out with. I'm scheduled to see my Dr again in April, and that's a ways away so I'm wondering if I need to get in early, or if my experience is normal. I'll post as many details as possible, but if I forget anything just let me know. 38...
  15. Nelson Vergel

    Men on TRT with no improvements in mood may have higher inflammation

    Blood Inflammatory Proteins and Psychological Symptoms during Testosterone Supplementation in Hypogonadal Men with the Metabolic Syndrome. - See more at: Abstract:Introduction:Low testosterone...
  16. P

    clomid and moods

    I have been on 50mg clomid 3x a week for about has brought my t up to 539 and free t to 105 and it is making me fertile again and that is what I was wanting. But lately my moods have been swinging. Also been having hip and knee pain. Does anyone have any insight if this is related to the...
  17. jger242

    HCG How long until it starts to work

    I am taking 250 ius 2 days and 250 ius 1 day prior to my weekly Tcyp injection.(100 mg) Mood seems improved and testicular aches greatly reduced after 2 1/2 weeks. How long until testicular size begins to come back? Thanks Jim
  18. Excel Male

    Benefits of Treating Hypogonadism (Testosterone Deficiency)

    Information provided by Gene Devine What are the Benefits of Treating Hypogonadism? Sexual dysfunction and low libido are among the most easily reversible symptoms of hypogonadism. Systematic reviews of randomized, placebo-controlled clinical trials of testosterone in men, including older men...
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