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  1. S

    Melatonin supplements before evening meal - yes or no?

    I stopped taking melatonin before bed as i eat my evening meal fairly late and i'd read that melatonin impairs insulin sensitivity. But i've just found this study and (to me at least), it seems to claim the opposite. Am i missing something here? I always liked using melatonin as i felt it...
  2. C

    Melatonin usage during daytime

    Hi. I want the benefits of using Melatonin as an antioxidant, but I can not take it pre bed. I get restless legs every time and it disturbs my sleep. I have read some information regarding use during the day on other sites, but can not find i anymore. Does anyone have experience with usage...
  3. Vince

    Melatonin and Brain

    Melatonin as a natural occurring free radical scavenger and an inducer of antioxidant enzymes has been well documented in thousands of publications within the last decade. Melatonin is no longer exclusively classified as a neurohormone since melatonin has been identified in bacteria, fungi...
  4. S

    Melatonin can enhance immunity in older or ill people and possibly prolong life
  5. K.pietera

    Trouble staying asleep

    Hi there , I have a hard time sleeping for as long as I remember but it worsened since I quit smoking weed. I've smoked weed on and off since I was 17 untill 25 ( I am now 30 ) I stopped because I got nasty panic attacks at the end and I've changed my life for the better ! Now I am suffering...
  6. A

    Melatonin Preventing Estrogen-Mediated Gene Transcription In Vitro

    This study (Melatonin blocks the activation of estrogen receptor for DNA binding - PubMed) seems to show that melatonin hinders the action of estrogen-bound estrogen receptors. "The present study shows that melatonin prevents, within the first cell cycle, the estradiol-induced growth of...
  7. Vince

    Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study

    The results obtained in the present study show that the chronic evening ingestion of melatonin in hypertensive patients well controlled by nifedipine GITS induces a blood pressure increase and a heart rate acceleration. Conclusions We...
  8. Vince


    No one knows why the sleep aid potentially increases horniness, but apparently, at low-to-medium doses, it gives some people the best orgasms of their lives
  9. Vince

    Melatonin: functional significance for optimal cellular physiology - Prof. Russel Reiter (14/11/19)

    My notes. Dr. Russell J. Reiter said he’s taken melatonin for 27 years to protect his mitochondria. He thinks that this protection, and other effects of melatonin, are far superior to what it does for sleep. One of the most important things that it does is to detoxify Reactive Oxygen Species...
  10. D

    Melatonin gives me insomnia?

    Used to work but now at best go to sleep for a few hours then wake. Even at lower doses. Seem to get this from any form of magnesium recently too. Used to love zma. Take theanine at that point. Takes awhile to take effect but at least I can get up for work. Anyone have any thoughts on this. TIA
  11. G

    Blue blocking glasses

    Has anyone tried using quality blue blocking glasses? If so, did you notice any positive benefits to using them? Just watched this episode of SuperHumanRadio, and I ended up buying a pair. The evidence seems pretty compelling.
  12. Nelson Vergel

    Melatonin As Potent as Letrozole in Inhibiting Aromatization of Testosterone to Estrogen

    ..."What really makes the results outstanding, though, is that melatonin was as potent as letrozole, the most potent antiaromatase inhibitor the publicly available pharmaceutical arsenal knows in suppressing cell proliferation, estradiol (E2) production and gene expression of CYP19A1...
  13. Nelson Vergel

    Long term melatonin supplementation may decrease sperm quality in men

    Melatonin administration alters semen quality in healthy men. Luboshitzky R, et al.Journal J Androl. 2002 Jul-Aug;23(4):572-8. Androl. 2004 Mar-Apr;25(2):185-6; author reply 186-7. Abstract The role of melatonin in the regulation of reproduction in humans is unknown. We conducted a 6-month...
  14. Nelson Vergel

    Protect your prostate with good sleep or melatonin supplements

    Men who sleep soundly are less likely to develop prostate cancer, a new study suggests. Higher levels of melatonin, a hormone produced at night which helps regulate the body's internal clock, were linked to a 75 per cent lower risk of developing an advanced form of the disease. But those...
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