free testosterone

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  1. F

    Target Free T Levels

    Gentlemen, My free T (details below) is in the middle of normal range per Quest. But, I feel really sluggish and I am working on figuring out (a) why? and, (b) how to treat it? I am trying to get a sense of where most guys feel "optimal" relative to their free T. I know there are a myriad of...
  2. S

    Chronically high SHBG and low free test (not on trt yet )

    I am hoping someone can shed some light on my current situation: 40 year old male, 5'10, 180 lbs Symptoms: Low energy, zero libido, poor recovery from exercise, fatigue Lifestyle: Don't drink, don't smoke, eat 40% carbs, 30% fat and 30% protein and 3000-4000 calories a day depending on energy...
  3. W

    Total T matter if Free is high?

    Like the title says. I know this is kind of a person specific and subjective question: For a sense of wellbeing, does Total Testosterone need to be high alongside a high Free T? Or would a normal Total T and high Free T yield similar results? Basically, I'm wondering if Total testosterone...
  4. jacb

    What it the purpose of Sex Hormone Binding Globulin (SHBG) ?

    My question might be a basic one, but what is the purpose of Sex Hormone Binding Globulin (SHBG)? In general terms I appreciate that SHBG binds to Total Testosterone (along with Albumin) to give us Free Testosteron. My question is not about what “normal values” of SHBG might be, it is more...
  5. jacb

    “Free Testosterone” Unit Conversion

    The US generally use nanograms/decilitre and picograms/millilitre, other countries, including New Zealand, use nanomoles/litre and picomoles/litre for their Free Testosterone results. I set out to find the conversion values. I found two useful links that can with some thought provide the...
  6. G

    Quest vs. Labcorp Free Test Ranges

    I was using an online calculator to see what my free T is from Quest to Labcorp, where on quest my free T is top of range in pg/mL, and Labcorp was ng/dL (I think?). Anyway, converting my top of range free T to Labcorp free T in their Unit resulted in having a free T in the middle of Labcorp's...
  7. N

    Mate is on test gel

    Hi guys . My mate is on 50mg gel a day. After about three months he is experiencing really bad headaches . I said 50mg is alot a day ... . I'm thinking his free t may be too high. I also got bad headaches when my free t was high .. I've told him to get bloods done but apart from dropping the gel...
  8. Nelson Vergel

    A novel spreadsheet method for calculating the free testosterone, free DHT, and free estradiol.

    Abstract In humans, testosterone (T), dihydrotestosterone (DHT), estradiol (E2), estrone (E1) and cortisol (C) bind to the serum proteins sex hormone-binding globulin (SHBG), albumin (Alb) and corticosteroid-binding globulin (CBG). Equilibrium dialysis is considered to be the "gold standard" for...
  9. D

    Free Testosterone Tests

    Hey Guys, I received two different sets of free testosterone labs and am trying to make sense of them. The first was LabCorp's Equilibrium FT test and the second was their Direct FT test. What is the difference and which labs would be more accurate in this case? For reference my SHBG is 20 and...
  10. J

    IGF-1 and Free T Increase Prostate Cance Risk

    From an article on the study: Risk was estimated using multivariable-adjusted Cox regression in 199,698 male UK Biobank participants. 2-sample Mendelian randomization (MR) analysis of IGF-I and risk used genetic instruments identified from UK Biobank men and genetic outcome data from the...
  11. B

    Thyroid,Bun,ast/alt feedback

    Hello everyone, I was wondering if I could get some feedback on my thyroid, bun(1st time my bun has been this high, it usually sits at 21), ast, and alt results. Feel free to ask about any other doubts you may have. A quick summary of what I have been doing. I did a 26 week cut and I know when...
  12. B

    AI monotherapy

    Has anyone tried, or can advise on AI monotherapy. My test levels are good but my free test is low, SHBG and est are high (bloods below). I was prescribed 125mg enanthate weekly and HCG 500iu 3 times a week yesterday, however I am extremely concerned about fertility and have decided to think...
  13. A

    What are all possible reasons for a higher total Testosterone number but significantly lower Free T number

    Like for example your bloodwork always comes back as around 20% above mid range Total T , but 20% below mid range Free T ?? anything you can do , or just genetics ?
  14. V

    Non typical High SHBG question

    Why does a low Free T % cause symptoms? I calculate 2 profiles. A guy with 600 total T and shbg at 30, and a guy with 800 total T with shbg at 50. Using an online free T calculator, guy 1 has a 2.30% free T and guy 2 has a 1.75%. Both will have similar direct free T numbers of 14 ng/dl. But...
  15. A

    Testosterone injections vs Clomid for secondary sexual characteristics, need help!

    Hi everyone, I'm 32 years old and have secondary hypogonadism (was diagnosed at 25 years old). I've been on clomid for around 7 years now that was prescribed by my urologist. My main question is whether testosterone injections are more effective than clomid for secondary sexual characteristics...
  16. W

    Lab measurement unit wrong? FT/TT = 0.14%* possible?

    My total testosterone is 886 ng/dl (900 is the top of the ref range), shbg = 67.67 nmol/l ( 18,30-54,10), albumin = 5.3 g/dL; I also tested my free testosterone and the lab result was 12.0 ng/l (8,30-40,10). If I convert it to ng/dl, that will be 1.2 ng/dl. This means that my FT/TT = 0.14%...
  17. N

    Know Nothing about Testosterone

    Sorry to "short-cut" reading all the posts here, but I don't know much about Testosterone and get overwhelmed quickly. What I'd like to know is (I had Radical Prostatectomy last June) what are the symptoms of low T? I've had fatigue, depression, less than ideal erections (Viagra worked well...
  18. J

    High Free Testosterone Level - Concern?

    My question is should I be concerned about having high Free T levels that exceed normal range both in total (23 pg/ml) and percentage (2.7%) ? Since moving to injections I have done two blood tests (not ideal times but based on travel to US where I can order my own test through DiscountLabs)...
  19. J

    Maximum Possible Free Testosterone Levels

    In follow up to my earlier post regarding my saliva tests, is it even humanly possible to have a Free Testosterone level of "2000 pg/ml" ?
  20. M

    HCG and Free Testosterone

    I did a scan for this but didn't see anything has anyone noticed an effect of HCG on their Free Testosterone ?
  21. M

    Men who switch from IM testosterone to subcutaneous injections: Any improvements?

    For those of you who switched to sub q, what has been the impact to your Total T, Free T, Estradiol and DHT ? Thanks !!!
  22. Nelson Vergel

    Tired of Being Tired?- A New Fatigue Exploration Panel Can Help

    Fatigue is can be very frustrating for many people since it can have several causes. There's the normal tiredness we feel at the end of every day, the tiredness that comes from being a hard-working person. But sometimes that fatigue goes beyond just the "norm". It pervades your muscles, fogs up...
  23. H

    High Free Testosterone level concerns?

    What concerns are there for having high Free Testosterone scores above the normal limits after two months of TRT when Total T, Estradiol, Hematocrit levels are all as expected? What are the next tests to consider if any?
  24. F

    Recent blood tests don't match up

    Hey guys, So I went to a doc two weeks ago that specializes in TRT. A little background on myself. I am 25 years old, 5'11" and 190 lb. When I was around 20 years old I started messing around with pro hormones and steroids without looking at the later consequences. As of the past 2 years my...
  25. Nelson Vergel

    Sex Hormone Binding Globulin and Estradiol Management - by Dr K. Kullis

    It has been traditionally thought and believed that sex hormone binding globulin (SHBG) is more or less correlated to estradiol (E) levels and the amount of free testosterone (FT). Free - testosterone is the portion of testosterone (T) that is available to enter a cell and bind to the androgen...
  26. Nelson Vergel

    How to decrease SHBG and increase free testosterone

    As shown in the figure above, about 2 percent of the testosterone in the body is active. This “free testosterone” is not attached to binding proteins that would prevent it from interacting with its receptor. About 40 percent of the body's testosterone is attached to albumin. This is a protein...
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