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  1. B

    E2 has jumped dramatically in the last couple of years, age related?

    My dose has stayed the same at 200mg a week for the last decade, and my e2 sensitive was usually in the low 60s which was fine with me But the last e2 sensitive test came back at 107! This is a huge jump considering the dose and the injection schedule has remained unchanged over that period. I...
  2. L

    Help! Advice before AI (Anastrozole)

    So I've been on TRT for a number of months, and can't seem to get dialed in. I feel lethargic, emotional/mild depression, no drive/motivation, low libido, weak erectile function. Doctor seems a bit flustered and asked what I think the issue is. After all my research, the only thing I can come up...
  3. M

    Anyone used/using calcium d glucarate for estrogen control?

    I've been reading a lot of good things lately about calcium d glucarate particularly in it's effectiveness of estrogen control. Just wondering if anyone on here has used it and can share their thoughts on it?
  4. G

    Help: T and E too high, I'm red etc.

    Hi all, I've been on TRT a little over a year. Started at 100mg a week; was tested a month in and numbers were still low so i was bumped to 150mg a week. I was tested about 6 weeks after the increase and my total t and free t were considered "optimal" - I believe total was right around 1000 and...
  5. M

    Could DIM have knocked my e2 too low?

    Current Protocol: 110Mg pw Test Cyp Injecting E2D I've always only needed a very small amount of anastrozole. Having seen Dr Crisler and others talk about using DIM (Diindolylmethane) for years, I decided I would give this a try instead of the anastrozole. I've been taking 200mg of DIM (100mg...
  6. J

    Do these look like results from a sensitive e2 test?

  7. W

    Anyone supplementing estrogen?

    It's pretty much the only hormone that I haven't tried. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854098/
  8. D

    Anyone feels better on less frequent injections? for ex.: e7d vs e3.5d

    So I have a lot of trouble dialing in my TRT. Started gel with low T of 260 ng/dl and <5 E2 (non sensitive) , undetectable. SHBG of 23. Felt like HELL. started androgel, felt the best i have ever felt in life after 4 days, this lasted for 1.5 weeks then I lost all my benefits and slowly became...
  9. T

    Sensitive E2 in the 100’s

    Was looking for input from some of the moderators/experienced users. I work in hormone optimization/peptides/ED management/primary care. First, huge thanks to this forum, Nelson and others who have been instrumental in advancing my understanding of TRT and how to engage in optimization versus...
  10. L

    TRT low, minimal E2 suggestions

    New user, long time lurker reading up. I'm a 42 yr old male, and I was diagnosed primary hypo around 2012. Ive been on TRT for 8+ years or so. Im using 100mg every 7 days IM. My question is, is it typical for my E2 to be in the lower range? My last test result was 13.1 in the range of 8.0...
  11. U

    I found a TRT protocol that works

    So after trying injections for 2.5 years I went back to testosterone pellets. I'm one week in and my libido is already coming back strong. I started on pellets 6 years ago and stayed on them for 3 years and they always worked great. I stopped them because every now and then I'd have one that...
  12. A

    Any evidence of Resveratrol lowering E2?

    Some have recommended Resveratrol to me as a means to lower E2 naturally. Has anyone had success lowering E2 a few points with resveratrol? I want to lower my e2 by 5-10 pg/mL
  13. T

    Sensitive to E2 - subq and HCG

    Hi guys, I'm very sensitive to medium to medium high E2. I feel like absolute shit, depressed, anxious, low libido. I talked to a new doctor who wants to put me on subq test Cyp and HCG: As far as I understand there's more aromatase in the fat, and so I'd think I would aromatise more with...
  14. A

    High e2 on 100mg

    I take 100mg once a week just got my sensitive e2 back 4 days after my shot and it was 59 range is less than 29. My Test level hasn’t come back yet but I’m freaking out because it explains why I’ve been breaking out. I could only imagine what my e2 is at the day after my shot. Should I split my...
  15. S

    List of compounds that have a propensity to aromatize to estradiol.

    I recently came across a thread where someone (@Cataceous ?) posted a nice chart showing many different compounds, family, propensity to aromatize to E2. Can’t find it now. If anyone could find it based on my vague description, I’d appreciate it!
  16. T

    Testogel - increased dosage and libido went down

    I'd been on 50mg/daily for 2 months. Morning wood was present every day. Did at most 0.5mg anasrozole. Bumped to 100mg/daily for 5 days, libido seems down, no morning wood, dry eyes.. I started by increasing anastrozole as well but dropped it for the last 2 of the 5 days. Has anyone...
  17. T

    Dry eyes on testogel?

    Hi guys, Has anyone experienced dry eyes with Testogel? I have been doing a bit of anastrozole as well but quit recently to see if this has to do with low E2. I experienced this after doubling the dose of the gel.
  18. A

    Low E2 but high prolactin?

    I have had high prolactin before which was mainly caused by an intense workout the day before the test but usually it also comes along with a raised E2. My recent test showed E2 as 20 pg/mL but Prolactin was 800 mU/L on a range of 80 - 320. Libido is on the floor and I am struggling with energy...
  19. D

    Updated labs, very low E2

    I am seeing my rheumatologist in a week, (have RA) and got a few labs to bring in, also wanted to see how my TT and FT levels were looking. I have very low SHBG (10-15 usually) and so my FT is always high. My regimen has changed a bit over the years, currently my goal is to decrease my FT, it is...
  20. Robotics

    High E2 Prolactin Low SHBG

    Been on 10mg cypionate IM a day for 5 weeks. prolactin and E2 are on the high end. I got a prescription for 0.0625 AI pills, I am considering starting with 3x a week. 1. Is my prolactin High due to my e2 and should it follow e2 down if i take ai? should i add in p5p? 2. I have my honeymoon in...
  21. Robotics

    AI 0.125 vs 0.0625 to go from E2 39 to 22 ?

    I am low shbg, daily injector, trying to get my E2 from 39 to the low 20's. Libido is my biggest issue. Feel free to see my other thread regarding my protocol. https://www.excelmale.com/forum/threads/low-libido-low-shbg-protocol-help-labs-x3.21084/ I have used 0.25 ai once or twice a week on...
  22. Robotics

    Low Libido, Low SHBG Protocol HELP - LABS x3

    Has anyone dealt with something similar? Libido seems to be illusive and hard to find. I am a low SHBG and struggle with libido/erections. daily injector IM (9mg x 7 = 63 mg week) The only time I have felt normal in that sense (libido) is usually when I am coming off TRT (for a week or two). Or...
  23. D

    Estrogen Dominance & Progesterone

    Hi, I have the symptoms of high E2 (bloating, mild gyno, ED, low libido, irritability, etc). I have been using Anatrozole but it is a fucking hit or miss, the times I ever felt good tye most it last are from a few days to a few hours. I have also tried to try with lower doses and no AI, but no...
  24. S

    Estradiol - Comparing ECLIA vs LC/MS/MS results

    I recently had lab work and got the ECLIA E2 test. I know my results for both tests are "high", however I'm curious as to how any comparison might be made to previous tests that used LC/MS/MS. Previous E2 labs using LC/MS/MS: 47.2 pg/ml (8.0-35.0) Current E2 labs using ECLIA: 69.2 pg/ml...
  25. R

    Question about E2 and Testosterone Percentage in the Body

    I have been on TRT for over 10 years. have always had my T in the 1200-1500 range and E2 from 12-26. I was on arrimidex at .25 mg E3D. I felt really good for the most part, then I started having issues and did something really wrong , started listening to regular doctors and lowered my T to...
  26. G

    What’s the difference between E2 sensitive by LabCorp and E2 ultrasensitive by Quest?

    Anyone know the difference between E2 sensitive, and E2 ultrasensitive? And which one should I get? They’re both the same price on discounted labs.com. Thanks.
  27. C

    Estrogen receptor damage from AI

    Hello, does any one else here at the moment runs in the same problems as me? I’ve been trt for about 4 years now, and used about three years aromatase inhibitors, letro arimidex and aromasin, i’ve been used them all, and always caused me crushes e2 symptoms when i took them even while my e2 was...
  28. M


    I'm not sure how to ask my question, but I would like to know the specifics on why low shbg is such a problem in regards to elevated E2? I understand that when one is low on shbg that E2 can get out of control, my question is why administering an AI doesn't work. I'll use my self as an...
  29. M

    Estradiol E2 Testing in Men: Comparison Between Regular and Sensitive E2 Assays

    Since this question is always a hot topic on here, I did both tests at the same time to see how far apart they were, Royal paid for the non-sensitive and I paid cash for the sensitive in the same blood draw: ESTRADIOL, SENSITIVE 22.6 PG/ML 8.0-35.0 02 Methodology: Liquid chromatography tandem...
  30. 5

    New guy, 10 mos. TRT, dosage/ED/libido questions

    Hey all - I've been on TRT for 10 months and just found this forum today - what a MASSIVE wealth of information! I've been relying on a single thread on another forum that's totally unrelated to health, and it's been a huge help, but nothing like this. I could really use your help today; TRT...
  31. D

    E2 levels for low SHBG guys (0-15)?

    Hi All, Can low SHBG guys comment on what is your protocol? and Whether it works successfully for libido and energy? - From what I have read and in my personal case, when E2 is low, mirroring SHBG values, it is like the sweet spot, and rationale is that the low SHBG makes too much of free E2...
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