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  1. E

    MIF-1 (and other peptides) for Anhedonia/Depression

    Thought I would start a discussion about this awesome lesser known peptide, yet one of the peptides with quite a few actual human studies behind it. So I'll start with my experience before getting to the science: I have done a few cycles (they last 5-7 days of 8-10 mg) of it this year and...
  2. G

    Low Dopamine and ADHD while on TRT

    Ive been circling around this for a while now. When I started(2020) TRT it was remarkable. I could inject 200mg a week. Sometimes 250-300 a week. Last year it all started spiraling down hill. I didnt notice that it was the trt, so I changed up numerous other things I was doing. Sex drive went...
  3. W

    How much of dosage change side effects are in relation to dopamine?

    This is more of what’s everyone’s opinion. When changes are made to testosterone dosages, let’s say lowering it for this instance. How much of those depressed, anxiety, no drive or libido type of feelings that come following a reduction in dosage, do you believe are mainly from the brain...
  4. B

    Dopamine: A hack on how to increase

  5. C

    Tips for lowering Norepinephrine levels?

    Hey guys, I wanted to ask if anyone has any tips on lowering norepinephrine levels. I read a thread in regards to doxazosin here on EM, I don’t have a PCP to ask in regards to an Rx to attempt, and I also fear that being only 28 and attempting to ask for this script I would get rejected. So I...
  6. W

    Using protocol change to spike dopamine?

    I have kept a crude TRT journal over the last several years, adding notes every week or so. On occasion, I will review the journal to spot any patterns or conclusions that I can draw with a reasonably high degree of certainty. This is how I often find myself repeating the same mistakes over...
  7. Fernando Almaguer

    Anyone else listening to these gem podcasts

    Hi all, Andrew Huberman and Derek from more plates more dates on YouTube have collabed to make a hormonal based podcast that is 3 hours long. In addition Huberman lab podcast has a wealth of new health protocols that one can follow to optimize everything from hormones to dopamine baseline...
  8. S

    TRT and Neurotransmitter Balance

    What effects, if any, does TRT have on neurotransmitters, particularly on serotonin? I know that in the initial stages of TRT, there is a pronounced effect on dopamine - I have been told that this is what causes the "honeymoon" that many guys experience. Are there neurotransmitter imbalances...
  9. Rock H. Johnson

    My 15 weeks experiment with Nandrolone.

    As with anything in life, one size does not fit all. So the following is anecdotal as in my subjective experience with Nandrolone Decanoate. When in last December chatter on the forum started to become louder on people adding Nandrolone to their protocol, I decided to go to my local friendly...
  10. K

    A Med that Boosts Dopamine that in Turn Boosts Libido?

    After taking it for less than 2 weeks, I've given up TRT androgel testosterone therapy since hair loss is a symptom I cannot risk possessing. Recently I read an article about a med that docs prescribe to boost dopamine levels in the brain that in turn boosts libido. Sadly I can't find this...
  11. I

    Chronic depression, fatigue, no libido all of my life

    Hello ! I'm 33 years old. I've chronic fatigue, depression and no libido (and no morning erections. Erections are good if I get horny.) all of my life. I often feel nervous too much and experience anxiety (including social. I'm an introvert). I have apathy which progresses with time. Also I...
  12. B

    Intuiv aka Guanfacine??????? Non-stimulant ADHD dopamine agonist

    I was talking to my doctor about lack of motivation due to no available stimulants to get me going hard in the gym... I have taken Modafinil in the past but it took about 300 to 400 mg's to get an effect which felt like old-school ephedra but I'd end up awake for a few days... and then it...
  13. Nelson Vergel

    13 Surprising Reasons You Should Increase Dopamine

    Without dopamine, we wouldn't be able to feel pleasure or motivation. It is also very important for our emotional responses, movement, pain, and the brain's pleasure and reward center. Many people seek out artificial sources of dopamine, which can lead to addiction. Read this post to learn about...
  14. Nelson Vergel

    Dopamine Drugs Are Turning Parkinson's Patients Into Picassos

    Dopamine is an important neurotransmitter, one whose functions is myriad and includes motor control, pleasure response, and habit reinforcement. Levels of dopamine in the brain have long been linked to a feeling of well-being, impulsivity control, and creativity. In a study in Behavioral...
  15. Nelson Vergel

    Using Dopamine Supplements to Hack Motivation: the Neurobiology of Ambition

    'Dopamine is the neurotransmitter that seems to make life itself rewarding. In this post, I'll teach you how to fuel your brain with dopamine supplements. Dopamine is the motivation molecule. It makes your favorite activities exhilarating and life accomplishments satisfying. Optimizing the...
  16. Nelson Vergel

    This Startup Gets You High On Dopamine, No Exercise Required

    IN BRIEF Using electric headphones, I zapped my brain's pleasure center. Here's what that's like. ALL OF THE FUN, NONE OF THE WORKOUT If you think about it, every company exhibiting at CES is trying to sell the same thing: happiness. But of the booths I visited last week at the yearly...
  17. Nelson Vergel

    Effect of Dopamine and Prolactin and Sex Drive

    This a very good read: "Dopamine. It's at the core of our sexual drives and survival needs, and it motivates us to do just about everything. This mechanism within the reward center of the primitive brain has been around for millions of years and has not changed. Rats, humans indeed, all mammals...
  18. Nelson Vergel

    Dopamine, Prolactin and Sex

    This a very good read: "Dopamine. It's at the core of our sexual drives and survival needs, and it motivates us to do just about everything. This mechanism within the reward center of the primitive brain has been around for millions of years and has not changed. Rats, humans indeed, all mammals...
  19. A

    Follow up bloodwork at 8 months on TRT - high prolactin?

    Hi all!!! My Test Cyp dosage varied initially from .5ml/week to 1ml/week with 250 iu HCG every day. I've settled on .5ml/week with 250iu hcg every day. Initial prolactin was measured at 4.8ng/ml with a range of 4-15.2ng/ml when I started TRT back in Feb 2014. Two weeks ago I got my new lab...
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