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  1. C

    Tips for lowering Norepinephrine levels?

    Hey guys, I wanted to ask if anyone has any tips on lowering norepinephrine levels. I read a thread in regards to doxazosin here on EM, I don’t have a PCP to ask in regards to an Rx to attempt, and I also fear that being only 28 and attempting to ask for this script I would get rejected. So I...
  2. Vince

    New Drug Could Help Stop Depression, Anxiety, Brain Injury, and Cognitive Disorders

    A new preclinical drug reported by James Bibb, Ph.D., and colleagues has the potential to combat depression, brain injury, and cognitive disorders. The drug, which is notable for being brain-permeable, works by inhibiting the kinase enzyme Cdk5. Cdk5 is an important signaling regulator in...
  3. F

    An Unusual Source of Anxiety

    I recently discovered a surprising source of anxiety for me and wanted to share my experience so it may help others. It took me a month or so to figure out that over the counter CoQ10 was causing me recurring bouts of anxiety and tachycardia as well as episodic insomnia. I was really surprised...
  4. A

    Latest Bloods. Appreciate Advice.

    Hi guys, I followed the advice of some of the members on here after I was put on 250mg a week and them that shall not be named and dropped my dose down to 118mg a week broken into daily doses on 16mg a day. After 7 weeks my bloods are as follows; SHBG - 25nmol/L Free T - 506 pmol/L (range -...
  5. A

    How to lower dose and avoid side effects

    Hi all, Just wondering if you can please provide some advice on lowering my T dose and minimise the side effects whilst doing so. I took some bad advice and having been doing 200mg every week (MWF). I believe it is causing me the current bout of anxiety, OCD and lethargy Im experiencing. I...
  6. T

    4 weeks off TRT - still needing AI to combat E2 anxiety

    Hey guys, Looking to get some input. I am 34 years old, low SHBG (17-19), 160lb, athletic build. I've spent the last year experimenting different protocols to find one where I feel good/normal. Surprisingly, the closest I can get to feeling fine is on a single injection frequency, with AI every...
  7. G

    Fish Oil and SHBG

    I can't find the pubmed study at the moment, but it's all over Google if searched. Apparently, fish oil lowers SHBG. I'm wondering how drastic this effect could be and if cutting my EPA/DHA dose from 2.4g to 1.2g may let it rise. I've read on here that guys with low SHBG have harder times...
  8. bochinit

    Someone having anxiety on TRT?

    Hello conrades, are someone here having anxiety or any other psychologic symptom of angryness or depression on trt? My anxiety spikes right before I inject (100mg per week/2x split) and lay down as days (half life obvious) pass by. I ger anxyous, agressive and have some insonia. Are anyone...
  9. W

    Starting back on TRT: Anxiety is real bad

    Anyone else have real bad anxiety after starting trt? Third week of starting back & the anxiety is about a 9 out of 10. Is it just the hormone levels getting adjusted that is causing this? I had this when I first started last time but I thought it was the other medication. Testosterone is the...
  10. C

    My regular ED regimen not working + anxiety - advice welcome

    Hi everyone. I’m 45 and been on TRT for 6 or 7 years now (Excelmale has been a fantastic resource!!). For the past 5 years I’ve had things dialed in pretty well. But the last few months I’ve been having anxiety and ED problems even though I have increased my daily Cialis to 15 mg!! (I’m not...
  11. M

    I think I failed my PCT

    Hi Guys This is going to be a long winded post, and I do understand I have been an idiot, I just wanted to pick someone's brains I'm 37 years old from UK, I had been on self prescribed TRT since November 2019. I decided to come off as I never really found any real benefits from when I was natty...
  12. T

    Trintellix for situational/performance anxiety?

    I've seen a few posts here from members — most recently Nelson himself — who have started taking Trintellix for anxiety or depression and seen an improvement in libido and erections. One poster called it a "wonder drug" that cured his "erection-killing anxiety." Was wondering how many posters...
  13. B

    Just starting TRT. Having a rough start with anxiety and insomnia.

    Hello. Thank you for all the work this forum does. I just started TRT for low libido and energy about 1wk ago (protocol below). I will do my best to limit this post to pertinent info and not write an intro novella. ACUTE ISSUES/CONCERNS : The day after my second 70mg Test E, I experienced...
  14. Fernando Almaguer

    A lot of folks dealing with anxitey and stress ... try this

    I like checking out what's new every so often and it has often had topics of anxiety issues sprinkled in there. Recently I learned of a self hypnosis app (interactive where you talk to it as well) called Reveri, it recommends twice daily sessions to learn how to deal with the uncertainty we...
  15. M

    Cymbalta users

    Is anybody here using or have used Cymbalta? my Doc wants me to try for anxiety (High BP) and chronic back pain. I read the horror stories but want some real answers.
  16. Z

    Letting e2 run wild

    My old dr was a dr who was all about not treating E2. He said let it go as high as you want and it won’t be a problem. Well I am seeing a new dr now and my e2 sensitive was 45. My libido has been super low, my anxiety kind of high, also my junk shrivels up to nothing along with my scrotum...
  17. Z

    High Testosterone and anxiety

    So I got some Of my labs back and the basics are my T was 1477 Free T-47 SHGB was 30 Hemocrit was 51 Hemoglobin was 17 IGF-1 was 180 PSA-0.6 this was done 24 hours after my last injection. I do 25mg everyday. But my question is, my anxiety has been a little on the higher side lately. I know...
  18. Z

    Testosterone Cream and DHT increase

    So I was on cream for about a year and in that year i noticed my anxiety was heightened. I also had other issues as stated of just feeling like crap. Anyways when doing labs, most my dht readings were upwards of 3-400. I was just wondering if that could of have been the culprit of my anxiety...
  19. T

    Anxiety and Depression increased since starting TRT

    I am on my 4th week of TRT. My testosterone was at 265 from a GP lab. Started at 150, 50 3/week. I was having high anxiety on injection day so this week I started 30 EOD. My anxiety and depression is worse than when I started. I am now second guessing using TRT. Should I continue and get labs in...
  20. Gianluca

    TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?

    In this video dr Mark Gordon, starting at 9min, explains how using good level of TRT can "burn" 5 alpha reductase enzyme, that beside being responsible for converting Test into DHT, it is also responsible for converting Progesterone into Allopregnanolone in the brain. Throughout the years on...
  21. D

    Switched from E3.5D to EOD. Need to lower dose??

    Trying to keep E2 and HCT under control. I have not had very restful sleep since I started Test 9 months ago, tired all the time. Gym work and sex has been great though. I figured I would try switching to more frequent injections. I switched 55mg e3.5d, to 30mg EOD. it’s only been a week...
  22. Z

    Cream question

    So I posted a couple days ago about cream issues. Basically I use to do injections felt good but switched over to the cream because I heard it was the cats meow. Well early on it was great, my libido was sky high. And well actually that’s about it. Everything else felt normal. Fast foward 1 year...
  23. T

    Switched to cypionate - anxiety or cold sweats in the middle of the night

    I was on gel, trough levels were 880ng/dl. I skipped the gel yesterday morning and took instead 0.2 ml of a 200 mg/ml vial. At 3:30 AM I woke up feeling really anxious in cold sweat. Do you reckon this is because the levels shot up too high? Or allergies to the oil? Edit: Isn't this a bit...
  24. N

    Depression and anxiety on TRT week 5 after great start.

    I've been on TRT for almost 5 weeks (started the 5th week last monday). I didn't feel much during the first 3 weeks, but at the beginning of the 4th week I started feeling much better. Very focused and clear of mind in a way I'd never experienced before. I've had brain fog my entire life and...
  25. T

    Anxiety / poor sleep / heart beat when bumping dose

    I've been experiencing some of this.. mild-moderate anxiety and feeling my heart beat a bit off when bumping my dose. Has anybody experienced this? Did your body adjust to the new dose?
  26. J

    TRT isn't forever? Natural T came back? Lab results suggestions please

    Back in early 2018...Panic attacks started out of nowhere, heart acting weird, some stress, etc age 39 Total T = 295 Free T = 15 E2 = 9 Pretty low for everything right? Did clomid for a while, numbers went up all to normal ranges, even up to 1100TT at one point, maybe felt a little better...
  27. S

    New User, Looking for advice, Questions about HCG, Thyroid, DHEA, etc.

    At age 33, After years of depression, anxiety, fatigue, weight gain, sleep problems, ed, etc. I convinced my doctor to test my hormones. I was specifically interested in my Cortisol levels due to prolonged profound amounts of physical anxiety. The results of what he tested were; Total...
  28. J

    Just starting TRT

    I am a 49 yr old male and have struggled with anxiety disorder for over 20 yrs. About a year and a half ago it became debilitating after having it under control with medication so my doctor started looking for answers. He found it when my lab work came back with a total test at 25! Lab results(...
  29. bochinit

    Anxiety and anger on TRT

    Hello! I would like to know why sometimes I feel anxiety or anger in trt? I would like to live in a constant state of comfort but apparently that ideal point is being difficult to reach. how do I stay calm in trt? does this have to do with dosage or some hormones affected?
  30. T

    I get anxiety when using hCG with TRT

    I've tried starting HCG several times over the last two years with similar results. By day 7 I start to have anxiety from it. I've tried 500 eod, 350, and 250 with the same results. I keep trying because it helps with my mood and well being the first couple of days. The doc seemed stumped...
  31. I

    Thinking of coming off TRT after 6 months...

    About 6 months ago I started TRT with a TT that ranged between 450-550 and a free T that was 10-11 ng/dl (range was 5-20). My symptoms were anxiety, no morning wood, poor erections, v low libido, no motivation etc for many years. I did 2 short steroid cycles in the past that probably didn’t...
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