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  1. W

    Low SHBG guys optimize free or total T?

    My SHBG is usually between 12 and 18, and I’ve always had the impression that I should almost ignore the free testosterone and just focus on the total, but I’m starting to wonder if I have it backward. I want a reasonable amount of testosterone for someone my age or just a little bit better, and...
  2. E


    Anyone use inositol for anxiety/ocd? The suggested dosage is around 18g/day for these conditions. I have used it in the past and seemed to work great for sleep at times and then not at all. I have also found if I take it for a week or two I start feeling a little sluggish during the day, but it...
  3. C

    Anxiety and TRT

    Hello, I have posted on here before about my start of TRT. In June of 2022 I developed pretty severe anxiety out of the blue. My background I never really had any anxiety my entire life. Maybe here and there with like big things that happen. I tested low testosterone right after getting...
  4. K

    Heart Palpitations, Chest Pain, and Anxiety with TestCyp.

    29 year old male, 155 lbs. Using 150 mg test cyp (75 mg 2x a week IM). I am dealing with heart palpitations, chest pain and anxiety for past couple weeks now. If i dial back to 50 mg or miss a dose it goes away with in a few days. I had this happen in the past but only with using 300 mg or so...
  5. B

    Seeking advice TRT Vs. Clomid

    Seeking advice. I am 37 years old. I've been on this journey for 5-6 years after significant chronic fatigue and anxiety symptoms sought to me start doing the thorough medical work up my family doctor refused to do. Prior to any intervention my Total T levels were usually between 390-530 and...
  6. W

    Anxiety When Lowering TRT Dose

    Most guy get anxiety as a side effect when starting trt, it’s very common until body gets adjusted to it. I always thought it was just bc more testosterone, higher dopamine and just body running at a higher gear so just an overall shock of the body. I’m starting to notice that same elevated...
  7. C

    More questions about anxiety

    My last shot was 10/26/2022. I get a shot once a week and this is week 2 completed on my new dose of .5ml / 100mg. I was on 80mg for 5 weeks before this. Nothing else. My Nurse Practitioner advised to go up. I will have my first blood test being on TRT. My question isn't about my dose...
  8. D

    Don’t know what to do now apart from stop

    I have been on TRT for just over 12 weeks now and I am thinking of switching providers or just stopping completely as after the 6 week mark I have been experiencing extreme insomnia waking after 2 hours sleep even when taking strong sleep meds from my GP and this was never the case pre TRT and...
  9. G

    Started TRT journey - five weeks in

    Good evening, everyone. I figured I'd make a thread documenting my progress. Hopefully the information and ensuing discussions contained herein could provide assistance for others down the line, as others' threads had provided for me. I also have some questions which will be added at the end, so...
  10. C

    Week 6 - stressful event

    The days leading up to completing week 6 were amazing for me. I went from having ups and downs to feeling like I was leveling off finally. I felt back to normal. I had an extremely stressful event involving my wife in the hospital. Everything will be fine thank god. My question is the...
  11. W

    How much Sam e for mood/depression?

    I was on 400mg for one month and felt nothing. Today I started taking 800mg and will see if it works. How much sam e do you guys take and is it safe to take a much higher dose?
  12. C

    I am on week 5-6 anxiety comes and goes

    Yesterday my anxiety was completely gone. I could think with a clear mind and had zero anxiety. Today when I woke up and was also good with zero anxiety. At around 12:30pm my anxiety came back slightly. Nothing like it was before. Before I would get panic attacks now my anxiety is slight...
  13. C

    Anxiety and low testoserione

    Hello, My name is Chris just had a few questions. In may of 2022 I got Covid 19 and developed issue around sleeping. I literally could not sleep at all or maybe I would get like 1-3 hours at most for almost a month straight. I had my testosterone checked on June 9th and had a level of 328...
  14. D

    Two weeks into TRT and a couple of questions

    Hello, I'm currently just over two weeks into TRT. Protocol is 200MG/ML Hydrogel cream from Empower. Two clicks in the morning, applying one click to scrotum and one to shoulder or chest area. Have not done follow up labs. The two positive things I have noticed so far is a marked increase in...
  15. C

    Tips for lowering Norepinephrine levels?

    Hey guys, I wanted to ask if anyone has any tips on lowering norepinephrine levels. I read a thread in regards to doxazosin here on EM, I don’t have a PCP to ask in regards to an Rx to attempt, and I also fear that being only 28 and attempting to ask for this script I would get rejected. So I...
  16. Vince

    New Drug Could Help Stop Depression, Anxiety, Brain Injury, and Cognitive Disorders

    A new preclinical drug reported by James Bibb, Ph.D., and colleagues has the potential to combat depression, brain injury, and cognitive disorders. The drug, which is notable for being brain-permeable, works by inhibiting the kinase enzyme Cdk5. Cdk5 is an important signaling regulator in...
  17. F

    An Unusual Source of Anxiety

    I recently discovered a surprising source of anxiety for me and wanted to share my experience so it may help others. It took me a month or so to figure out that over the counter CoQ10 was causing me recurring bouts of anxiety and tachycardia as well as episodic insomnia. I was really surprised...
  18. A

    Latest Bloods. Appreciate Advice.

    Hi guys, I followed the advice of some of the members on here after I was put on 250mg a week and them that shall not be named and dropped my dose down to 118mg a week broken into daily doses on 16mg a day. After 7 weeks my bloods are as follows; SHBG - 25nmol/L Free T - 506 pmol/L (range -...
  19. A

    How to lower dose and avoid side effects

    Hi all, Just wondering if you can please provide some advice on lowering my T dose and minimise the side effects whilst doing so. I took some bad advice and having been doing 200mg every week (MWF). I believe it is causing me the current bout of anxiety, OCD and lethargy Im experiencing. I...
  20. T

    4 weeks off TRT - still needing AI to combat E2 anxiety

    Hey guys, Looking to get some input. I am 34 years old, low SHBG (17-19), 160lb, athletic build. I've spent the last year experimenting different protocols to find one where I feel good/normal. Surprisingly, the closest I can get to feeling fine is on a single injection frequency, with AI every...
  21. G

    Fish Oil and SHBG

    I can't find the pubmed study at the moment, but it's all over Google if searched. Apparently, fish oil lowers SHBG. I'm wondering how drastic this effect could be and if cutting my EPA/DHA dose from 2.4g to 1.2g may let it rise. I've read on here that guys with low SHBG have harder times...
  22. bochinit

    Someone having anxiety on TRT?

    Hello conrades, are someone here having anxiety or any other psychologic symptom of angryness or depression on trt? My anxiety spikes right before I inject (100mg per week/2x split) and lay down as days (half life obvious) pass by. I ger anxyous, agressive and have some insonia. Are anyone...
  23. W

    Starting back on TRT: Anxiety is real bad

    Anyone else have real bad anxiety after starting trt? Third week of starting back & the anxiety is about a 9 out of 10. Is it just the hormone levels getting adjusted that is causing this? I had this when I first started last time but I thought it was the other medication. Testosterone is the...
  24. C

    My regular ED regimen not working + anxiety - advice welcome

    Hi everyone. I’m 45 and been on TRT for 6 or 7 years now (Excelmale has been a fantastic resource!!). For the past 5 years I’ve had things dialed in pretty well. But the last few months I’ve been having anxiety and ED problems even though I have increased my daily Cialis to 15 mg!! (I’m not...
  25. M

    I think I failed my PCT

    Hi Guys This is going to be a long winded post, and I do understand I have been an idiot, I just wanted to pick someone's brains I'm 37 years old from UK, I had been on self prescribed TRT since November 2019. I decided to come off as I never really found any real benefits from when I was natty...
  26. T

    Trintellix for situational/performance anxiety?

    I've seen a few posts here from members — most recently Nelson himself — who have started taking Trintellix for anxiety or depression and seen an improvement in libido and erections. One poster called it a "wonder drug" that cured his "erection-killing anxiety." Was wondering how many posters...
  27. B

    Just starting TRT. Having a rough start with anxiety and insomnia.

    Hello. Thank you for all the work this forum does. I just started TRT for low libido and energy about 1wk ago (protocol below). I will do my best to limit this post to pertinent info and not write an intro novella. ACUTE ISSUES/CONCERNS : The day after my second 70mg Test E, I experienced...
  28. Fernando Almaguer

    A lot of folks dealing with anxitey and stress ... try this

    I like checking out what's new every so often and it has often had topics of anxiety issues sprinkled in there. Recently I learned of a self hypnosis app (interactive where you talk to it as well) called Reveri, it recommends twice daily sessions to learn how to deal with the uncertainty we...
  29. M

    Cymbalta users

    Is anybody here using or have used Cymbalta? my Doc wants me to try for anxiety (High BP) and chronic back pain. I read the horror stories but want some real answers.
  30. Z

    Letting e2 run wild

    My old dr was a dr who was all about not treating E2. He said let it go as high as you want and it won’t be a problem. Well I am seeing a new dr now and my e2 sensitive was 45. My libido has been super low, my anxiety kind of high, also my junk shrivels up to nothing along with my scrotum...
  31. Z

    High Testosterone and anxiety

    So I got some Of my labs back and the basics are my T was 1477 Free T-47 SHGB was 30 Hemocrit was 51 Hemoglobin was 17 IGF-1 was 180 PSA-0.6 this was done 24 hours after my last injection. I do 25mg everyday. But my question is, my anxiety has been a little on the higher side lately. I know...
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