• TRT & Older Men: A Look at "The Testosterone Trials"

      The Testosterone Trials are set of multi-institutional, double blind, placebo-controlled studies aimed primarily at determining the efficacy of testosterone replacement therapy (TRT) on sexual function, physical function, and vitality.

      • Seven hundred and ninety men over the age of 65 yr with symptoms of hypogonadism and a serum testosterone concentration of <275 ng/dl were randomized to receive either an initial dose of 5 g of 1% testosterone gel or placebo gel once a day.
      • Serum testosterone levels and improvement in symptoms were assessed at baseline and at 3 mo, 6 mo, 9 mo, and 12 mo.
      • Ninety-one percent of men maintained normalized testosterone levels throughout the duration of the study.
      • TRT improved sexual desire (DISF-M-II), frequency of sexual activity (Personality Diagnostic Questionnaire-4), and erectile function (International Index of Erectile Function).
      • However, TRT did not confer any significant benefits in terms of vitality.
      • In the physical function trial, there was no significant difference between TRT and placebo in terms of the percentage of men with an increase of 50 m or greater in the 6-min walking distance.
      • However, on inclusion of all men enrolled in the three trials, TRT was associated with a significantly higher percentage of men with an increase of ≥50 m in the 6-min walking distance.
      • More men in the TRT group had an increase in prostate specific antigen ≥1 ng/ml, but there was no difference in the number of men diagnosed with prostate cancer 1 yr after the study period. Similarly, there was no difference in the number of men who experienced major cardiovascular events or died during the study period.

      "Re: Effects of Testosterone Treatment in Older Men," European Urology, 2016 September, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123669/

      This article was originally published in forum thread: TRT & Older Men: A Look at "The Testosterone Trials"
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      Welcome to ExcelMale.com, one of the largest and best moderated men’s health forums on the Internet focused on increasing health, potency and productivity in men. With over 13,000 members (as of April 2016) that include educated men, physicians, pharmacists, dietitians, exercise trainers, nutritional supplement experts, and other professionals in the field, ExcelMale is fast becoming a leader in the field. Our forum topics range from testosterone replacement therapy, Trimix injections use for ED, HCG use for better fertility and libido, estradiol management, thyroid function optimization, peptide information, exercise routines, best supplements for men, high protein diets, testosterone side effect management and much more. We also provide men’s health information via Interviews with experts, Videos, and webinars. Last but not least, our members share their reviews of hormone replacement clinics and doctors, compounding pharmacies, pharmaceutical products, supplements, and much more. Our great moderators review every post daily to detect spammers or abuse, so ExcelMale is a safe environment for all men. And since every man wants to help important women in their lives, we do not neglect female health information as we include a folder called “ExcelFemale” to post the latest on HRT in women.

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