• Estradiol Inhibits Certain Inflammatory Activation of C-Reactive Protein

      Cardiovascular disease (CVD) is currently the most important cause of death in developed countries.

      • Atherosclerosis, the underlying cause of most CVDs, is a dynamic and progressive inflammatory disease characterized by lipid plaque formation within the arterial wall and luminal reduction. In fact, accumulating
      • Data suggests that the inflammatory process plays a central role in the initiation, progression, and the final steps of this pathology as vulnerable plaque rupture.
      • The C-reactive protein (CRP) has emerged as the most powerful predictor and is an extensively studied systemic marker of inflammation of high sensitive CRP (hsCRP) correlates with the risk of future atherosclerotic events.
      • This plasmatic protein synthesized by hepatocytes in response to inflammation and tissue injury induces pro-inflammatory molecules' expression by endothelial cells (ECs).
      • Previous studies showed that the 17β-estradiol (E2) has beneficial effects on vascular cells by reducing in vitro pro-inflammatory molecules expressions in EC. It is hypothesized that E2 blocks or reduces CRP-mediated inflammatory responses by modulating endogenous production of CRP in EC and/or activation mechanisms.
      • A 1-h pre-treatment of E2 at a physiologic dose (10−9 M) leads to an important decrease of CRP production suggesting a partial blockage of its amplification loop mechanism.
      • Furthermore, in HAEC, E2 reduces the secretion of the most potent agonist of CRP induction, the IL-6, by 21 %. E2 pre-treatment also decreased the expression of pro-inflammatory molecules IL-8, VCAM-1, and ICAM-1 induced by CRP and involved in leukocytes recruitment.
      • In addition, we demonstrated that E2 could restore vascular endothelial growth factor-mediated EC migration response impaired by CRP suggesting another pro-angiogenic property of this hormone.

      "Effect of C-reactive protein on chemokine expression in human aortic endothelial cells," Journal of Molecular and Cellular Cardiology, 2004 March, https://www.ncbi.nlm.nih.gov/pubmed/23111890

      This article was originally published in forum thread: Estradiol Inhibits Certain Inflammatory Activation of C-Reactive Protein
      Comments 1 Comment
      1. Vince's Avatar
        Vince -
        Does low estradiol cause joint pain in men because of inflammation?

    • You have probably reached our site in your search for health and potency. Are you wondering who to trust with men’s health information in an online world full of scammers and deception? Well, you are in the right place!

      Welcome to ExcelMale.com, one of the largest and best moderated men’s health forums on the Internet focused on increasing health, potency and productivity in men. With over 13,000 members (as of April 2016) that include educated men, physicians, pharmacists, dietitians, exercise trainers, nutritional supplement experts, and other professionals in the field, ExcelMale is fast becoming a leader in the field. Our forum topics range from testosterone replacement therapy, Trimix injections use for ED, HCG use for better fertility and libido, estradiol management, thyroid function optimization, peptide information, exercise routines, best supplements for men, high protein diets, testosterone side effect management and much more. We also provide men’s health information via Interviews with experts, Videos, and webinars. Last but not least, our members share their reviews of hormone replacement clinics and doctors, compounding pharmacies, pharmaceutical products, supplements, and much more. Our great moderators review every post daily to detect spammers or abuse, so ExcelMale is a safe environment for all men. And since every man wants to help important women in their lives, we do not neglect female health information as we include a folder called “ExcelFemale” to post the latest on HRT in women.

      Search our content by typing your question here.

      Register here to join our community! Don’t be shy, ask questions by posting in any forum folder. We can help each other to regain our best selves!.

      Wishing you the greatest health,

      Nelson Vergel