ExcelMale.com
    • Testosterone & E2 Mediate HDL Particle Size

      Exogenous testosterone decreases serum levels of high-density lipoprotein cholesterol (HDL-C) in men, but whether this reflects altered HDL function is uncertain.

      • Healthy men (n=45, 19-55 years of age) were rendered medically castrate with the GnRH antagonist acyline for 4 weeks and administered either 1) placebo gel, 2) low-dose testosterone gel (1.62%, 1.25 g), 3) full replacement dose testosterone gel (5 g) or 4) full replacement dose testosterone gel with an aromatase inhibitor.
      • At baseline and end-of-treatment, serum total and ABCA1-specific CEC were quantified, and HDL particle size and concentration were measured through calibrated ion mobility analysis.
      • As expected, a significant time-by-group interaction was observed for serum levels of HDL-C, with significant increases in HDL-C evident after both complete and partial testosterone deprivation.
      • However, serum testosterone level was not associated with changes in CEC. In contrast, change in serum 17β-estradiol level exhibited an inverse association with ABCA1-specific efflux (β=-0.48 per 10 pg/mL change in serum 17β-estradiol, p=0.002).
      • Change in l-HDL-P% correlated inversely with change in serum testosterone level, but positively with change in serum 17β-estradiol level (β=0.50 per 10 pg/mL change in serum 17β-estradiol, p=0.001).


      Testosterone-mediated changes in serum HDL-C may not reflect changes in HDL CEC. Testosterone and estradiol both may contribute to the regulation of HDL particle size in men.

      "Testosterone and Estradiol Mediate Discrete Effects on High-density Lipoprotein Particle Size and Sterol Efflux Capacity in Healthy Men," Circulation, 2017, 136 http://circ.ahajournals.org/content/136/Suppl_1/A14585

      This article was originally published in forum thread: Testosterone & E2 Mediate HDL Particle Size
    • You have probably reached our site in your search for health and potency. Are you wondering who to trust with men’s health information in an online world full of scammers and deception? Well, you are in the right place!

      Welcome to ExcelMale.com, one of the largest and best moderated men’s health forums on the Internet focused on increasing health, potency and productivity in men. With over 13,000 members (as of April 2016) that include educated men, physicians, pharmacists, dietitians, exercise trainers, nutritional supplement experts, and other professionals in the field, ExcelMale is fast becoming a leader in the field. Our forum topics range from testosterone replacement therapy, Trimix injections use for ED, HCG use for better fertility and libido, estradiol management, thyroid function optimization, peptide information, exercise routines, best supplements for men, high protein diets, testosterone side effect management and much more. We also provide men’s health information via Interviews with experts, Videos, and webinars. Last but not least, our members share their reviews of hormone replacement clinics and doctors, compounding pharmacies, pharmaceutical products, supplements, and much more. Our great moderators review every post daily to detect spammers or abuse, so ExcelMale is a safe environment for all men. And since every man wants to help important women in their lives, we do not neglect female health information as we include a folder called “ExcelFemale” to post the latest on HRT in women.


      Search our content by typing your question here.

      Register here to join our community! Don’t be shy, ask questions by posting in any forum folder. We can help each other to regain our best selves!.


      Wishing you the greatest health,

      Nelson Vergel

      Founder