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    • Testosterone Therapy: Adhering to Treatment/Modes of Treatment

      An older study, but one worth considering.

      To determine which modes of treatment resulted in the highest rates of adherence, a retrospective claims database study from January 2005 through December 2011 was undertaken. The study included 106,039 men, 18-65 years of age who had initiated TRT and were diagnosed with hypogonadism or hypogonadotropic hypogonadism. A minimum of 6 months continuous enrollment before and 12 months after the TRT index date was required. Adherence was measured by the Mediation Possession Ratio (MPR) and the Proportion of Days Covered (PDC), with the adherence rate defined as MPR≥0.8. The rate of the first switching was summarized by TRT formulation.

      • The overall adherence rate over 12 months was 21.4% ranging from 28% (pellets), 19.9% (SAIs), 17.7% (gels), 7.8% (buccal), and 6.6% (patch), respectively. Similarly, the average PDCs were significantly higher for pellets (0.59) compared to gels (0.43), SAIs (0.39), buccal (0.28), and patch (0.27) (P<0.001). About 13% (n = 13,577) of patients switched from their initial therapy to a different TRT formulation. Patients starting with patch were most likely to switch to a different formulation (39.3%), followed by patients with SAIs (12.1%), pellets/buccal (12.0%), and gels (10.3%).


      "Medication adherence and switching rates of patients with testosterone replacement therapy (TRT) in the United States," Value in Health Journal, May 2014, http://www.valueinhealthjournal.com/...586-1/fulltext

      This article was originally published in forum thread: Testosterone Therapy: Adhering to Treatment/Modes of Treatment
      Comments 4 Comments
      1. LTChris's Avatar
        LTChris -
        wow, if I am understanding this correctly, it is no wonder that some men have horrible experiences on TRT with such low adherence rates. Do you think pellets are so high just because you really have no choice but to adhere?
      1. CoastWatcher's Avatar
        CoastWatcher -
        Quote Originally Posted by LTChris View Post
        wow, if I am understanding this correctly, it is no wonder that some men have horrible experiences on TRT with such low adherence rates. Do you think pellets are so high just because you really have no choice but to adhere?
        That was what I immediately thought.
      1. Weasel's Avatar
        Weasel -
        Quote Originally Posted by CoastWatcher View Post
        That was what I immediately thought.

        My thought as well.
      1. CoastWatcher's Avatar
        CoastWatcher -
        Quote Originally Posted by Weasel View Post
        My thought as well.
        Lock 'em in and leave 'em.
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