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    • Estradiol, Depression, & Obesity in Men

      Several studies have shown a positive association between depression and obesity; however the underlying mechanisms are not fully understood. It is not known if this association is driven by altered sex hormone levels in men due to increased BMI.

      • A total of 3925 men (2244<60years and 1681>60years) were included into analyses. Associations between BMI, sex hormones and depressive symptomatology according to CES-D score were evaluated.
      • Obese men had, compared to normal weight controls:
      • Lower total testosterone and free testosterone
      • Increased estradiol in older group only. Men <60years old with depressive symptomatology had higher estradiol levels compared to those without depressive symptomatology, however no association with BMI was observed.


      Selected sex hormone parameters were significantly different in overweight and obese compared to normal weight males and certain differences could be seen between younger and older males. Depressive symptomatology was associated with increased estradiol levels in younger men, regardless of BMI.

      "Increased Estrogen Level Can be Associated With Depression in Males," Psychoneuroendocrinology, 2 November 2017

      https://www.ncbi.nlm.nih.gov/pubmed/29107881/

      This article was originally published in forum thread: Estradiol, Depression, & Obesity in Men
      Comments 1 Comment
      1. CoastWatcher's Avatar
        CoastWatcher -
        From the material that could be accessed, it would seem that estradiol was NOT measured via the sensitive, LC, MS/MS lab test. The reference ranges and the fact that the test was conducted by European researchers strongly suggests that.
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      Welcome to ExcelMale.com, one of the largest and best moderated men’s health forums on the Internet focused on increasing health, potency and productivity in men. With over 13,000 members (as of April 2016) that include educated men, physicians, pharmacists, dietitians, exercise trainers, nutritional supplement experts, and other professionals in the field, ExcelMale is fast becoming a leader in the field. Our forum topics range from testosterone replacement therapy, Trimix injections use for ED, HCG use for better fertility and libido, estradiol management, thyroid function optimization, peptide information, exercise routines, best supplements for men, high protein diets, testosterone side effect management and much more. We also provide men’s health information via Interviews with experts, Videos, and webinars. Last but not least, our members share their reviews of hormone replacement clinics and doctors, compounding pharmacies, pharmaceutical products, supplements, and much more. Our great moderators review every post daily to detect spammers or abuse, so ExcelMale is a safe environment for all men. And since every man wants to help important women in their lives, we do not neglect female health information as we include a folder called “ExcelFemale” to post the latest on HRT in women.


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