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    • Testosterone Replacement Enhances the Effects of Metformin on Lipids and Inflammation

      Exp Clin Endocrinol Diabetes 2015; 123(10): 608-613

      The Effect of Metformin and Metformin-Testosterone Combination on Cardiometabolic Risk Factors in Men with Late-onset Hypogonadism and Impaired Glucose Tolerance


      Abstract

      No previous study has investigated the effect of metformin, administered alone or together with testosterone, on cardiometabolic risk factors in men with hypogonadism. The study included 30 men with late-onset hypogonadism (LOH) and impaired glucose tolerance (IGT) who had been complying with lifestyle intervention. After 12 weeks of metformin treatment (1.7 g daily), the participants were allocated to one of 2 groups treated for the following 12 weeks with oral testosterone undecanoate (120 mg daily, n=15) or not receiving androgen therapy (n=15). Plasma lipids, glucose homeostasis markers, as well as plasma levels of androgens, uric acid, high-sensitivity C-reactive protein (hsCRP), homocysteine and fibrinogen were determined before and after 12 and 24 weeks of therapy with the final dose of metformin. Patients with LOH and IGT had higher levels of hsCRP, homocysteine and fibrinogen than subjects with only LOH (n=12) or only IGT (n=15). Metformin administered alone improved insulin sensitivity, as well as reduced 2-h postchallenge plasma glucose and triglycerides. Testosterone-metformin combination therapy decreased also total and LDL cholesterol, uric acid, hsCRP, homocysteine and fibrinogen, as well as increased plasma testosterone. The effect of this combination therapy on testosterone, insulin sensitivity, hsCRP, homocysteine and fibrinogen was stronger than that of metformin alone. The obtained results indicate that IGT men with LOH receiving metformin may gain extra benefits if they are concomitantly treated with oral testosterone.

      This article was originally published in forum thread: Testosterone Replacement Enhances the Effects of Metformin on Lipids and Inflammation
      Comments 8 Comments
      1. GEORGE TOULIATOS's Avatar
        GEORGE TOULIATOS -
        At the moment i use 850mg of metmorfin,along with 4 iu of somatropin and 100mg of testim gel,plus 160mg of TU (andriol) oily caps.
      1. J2048b's Avatar
        J2048b -
        Quote Originally Posted by GEORGE TOULIATOS View Post
        At the moment i use 850mg of metmorfin,along with 4 iu of somatropin and 100mg of testim gel,plus 160mg of TU (andriol) oily caps.
        man i wish i could manage to get some gh!! that would complete my anti aging adventure and make me a happy duckling!

        why do u use met?
      1. J2048b's Avatar
        J2048b -
        i guess ill start my metformin sooner than i thought as my doc prescribed me some due to high insulin levels recently...
      1. kettlebellfreak64's Avatar
        kettlebellfreak64 -
        I'm on Metformin i take 1 850mg dose a day but i also eat a lowcarb moderate fat diet which keeps my BS in check damn near normal when i eat real correct my fasting BS inmorning is 90-110 i need to lose about 50lbs build some muscle and i can get off it and probably my HBP meds too!!
      1. kettlebellfreak64's Avatar
        kettlebellfreak64 -
        Great post Vergel!!
      1. MarkLA's Avatar
        MarkLA -
        Interesting that T+Metformin reduces homocysteine. I had read that Metformin worsens (increases) homocysteine when used alone.
      1. GEORGE TOULIATOS's Avatar
        GEORGE TOULIATOS -
        As known,somatropin lowers insulin sensitivity and establishes insulin resistance.Metformin is known to make cellular receptors more sensitive to insulin.Testosterone also improves insulin sensitivity,perhaps due to improvement in lean body mass (BMI).Daibetic patients who use insulin,have to adjust and lower their daily dosage,while on testosterone.
      1. GEORGE TOULIATOS's Avatar
        GEORGE TOULIATOS -
        Quote Originally Posted by J2048b View Post
        man i wish i could manage to get some gh!! that would complete my anti aging adventure and make me a happy duckling!

        why do u use met?
        As known,somatropin lowers insulin sensitivity and establishes insulin resistance.Metformin is known to make cellular receptors more sensitive to insulin.Testosterone also improves insulin sensitivity,perhaps due to improvement in lean body mass (BMI).Daibetic patients who use insulin,have to adjust and lower their daily dosage,while on testosterone.
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