• Why is HCG Important for Men on Testosterone Replacement Therapy?

    Nelson Vergel from www.ExcelMale.com explains the benefits of human chorionic gonadotropin (hCG) use in men with low testosterone beyond fertility and testicular atrophy reversal. For more details go to:https://www.excelmale.com/showthread.... and watch https://www.youtube.com/watch?v=0uXoB...

    This article was originally published in forum thread: Why is HCG Important for Men on Testosterone Replacement Therapy?
    Comments 3 Comments
    1. Weasel's Avatar
      Weasel -

      Couple Questions,

      1. Can the same results be achieved by supplementing PREG/DHEA vs HCG?

      2. Have you saw any studies or evidence that HCG will increase DHT more than just testosterone will?
    1. MikeXL's Avatar
      MikeXL -
      What always bothered my about the concept of back filling the pathways is that it Presumes that the pathways need to be back filled. I realize that once on TRT, less of the higher-up-the-chain hormones are produced. However, that could merely be because less are needed given the patient is now on TRT. Pregnenolone, progesterone and DHEA are still needed when you commence TRT. And we see a decrease, but we don't see a complete shutdown like we do with LH and FSH. Perhaps the body merely down regulates them just enough to give the patient only what is needed, which would be less now that none is needed for producing T.

      And that leads me to the next thing. If LH really was needed for something other than testosterone, why would the body produce zero just because of TRT ?
    1. Nelson Vergel's Avatar
      Nelson Vergel -
      Excellent observation. Evolution has made it possible to get every hormone axis to self-regulate depending on the amount of hormones in it. It was never intended to get hormones supplied from the outside world. The downregulation of the HPTA shuts down LH and FSH with obvious physiological disadvantages like low or no fertility. Replacing T via physiologic TRT normalizes only one hormone while leaving LH, FSH, pregnenolone and progesterone low or nil. DHT and E2 remain OK since they are downstream of T. If the body was just slowing down production of all those suppressed hormones to adjust them due to less need for them, why would the axis keep an important hormone like FSH shut down. That hormone ensures the survival of our species via sperm production. If this self-regulation was just part of homeostasis, then all organ functions would eventually be normalized (including testicular sperm production). We can speculate all day since we have hardly any data on the subject.

      There are references showing that LH itself may also have other roles since LH receptors are everywhere including the brain. Unfortunately, we do not have any scientific information of what happens to those receptor with long term LH shutdown. The same thing can be said about the shut down of pregnenolone and progesterone. Those two hormones have some limited references about their role in men's health:

      https://www.excelmale.com/showthread...cursor-Hormone and


      This is an emerging field and we hope to see more studies that actually provide solid data on issues surrounding long term shut down of the HPTA and upstream steroid hormones caused by TRT.