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      Metformin, the first-line antihyperglycemic, has been touted as something of a wonder drug with strong, anti-aging properties. A recent study conducted in Toronto was undertaken to determine if Metformin ...
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      Another paper in the Asian Review of Andrology reviews the studies of cardiovascular events that were based on analyzing prescription records. Each study is summarized and its weaknesses discussed. The ...
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      New evidence suggests that fluoride may be an sexual hormone disruptor. From the abstract:

      We conducted a cross-sectional study in rural areas of Henan province in China to explore the interaction
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      It's been well established that waist circumference is a useful, reliable predictor for cardiovascular risk. However, until earlier this year it was not certain what its value was in regard to sexual ...
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      While there have been studies of the role TRT may play in terms of cardiovascular disease, there have been few focusing specifically on TRT and stroke. Testosterone Replacement Therapy and the Risk of ...
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      Does adding the measurement of cystatin C to that of serum creatinine to determine estimated glomerular filtration rate improve its accuracy? That's the question asked by researchers who undertook a meta-analysis of 11 general population studies (90,750 participants) and five studies of cohorts with chronic kidney disease (2,960 participants) for whom standardized measurements of serum creatinine and cystatin C were available.


      • Researchers compared the association of the eGFR as calculated by the measurement of creatinine or cystatin C alone or in combination with creatinine, with the overall rate of death, death from cardiovascular causes, and end-stage renal disease.
      • Across all eGFR categories, the reclassification of the eGFR to a higher value with the measurement of cystatin C, as opposed to creatinine, was associated with a reduced risk of all three study outcomes; reclassification to a lower eGFR was associated with an increased risk.
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      Urologists see it all the time. Pain in or near the scrotum, perineum, or penis, frequently made worse by urination or ejaculation. A diagnosis of prostatitis is made and antibiotics start. Followed by more antibiotics. Prostatitis has been subdivided, bacterial/non-bacterial/chronic/acute, and sometimes classified as urethritis or cystitis.


      Perhaps there's a better way. Dr. Jeanette Potts, an American urologist, suggested as much in her article Male Pelvic Pain: Beyond Urology and Chronic Prostatitis, "Current Urology Rheumatology Review," v. 12, number 2, 2015, that over the course of many years she came to realize that in many, though certainly not all, "prostatitis" cases, something more was going on.
      "Thoughtful interview and methodical physical examination can very often reveal pelvic floor muscle dysfunction, Myofascial pain syndromes, Functional Somatic Syndrome/Central Sensitization Syndromes and/or psychosocial distress.

      One must be aware that many of these syndromes frequently overlap. Acknowledgement of these conditions and validation of both their physical and psychological distress is paramount to creating trust and confidence in the patient. These are the cornerstones for empowerment and self-care required in the management of chronic pelvic pain."

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      A recent study published in Diabetologia investigated the impact of DHEA, DHEAS, androstenedione, and the ratio of DHEAS to DHEA on type II diabetes.

      Data from 5,189 men and women were gathered. After adjusting for age, sex, cohort, fasting status, fasting glucose, insulin, and BMI, "both serum DHEA and serum DHEAS levels were inversely associated with risk of type II diabetes in the total population." Further analysis showed that androstenedione was not associated with risk of type II diabetes, not what the DHEAS to DHEA ratio.

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      Article Preview
      BACKGROUND
      Reported declines in sperm counts remain controversial today and recent trends are unknown. A definitive meta-analysis is critical given the predictive value of sperm count for fertility, morbidity and mortality.





      OBJECTIVE AND RATIONALE
      To provide a systematic review and meta-regression analysis of recent trends in sperm counts as measured by sperm concentration (SC) and total sperm count (TSC), and their modification by fertility and geographic group.


      “In this comprehensive meta-analysis, sperm counts whether measured by SC or TSC declined significantly among men from North America, Europe and Australia during 1973–2011, with a 50–60% decline among men unselected by fertility, with no evidence of a ‘leveling off' in recent years,” the authors concluded.

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      Women who take hormone replacement therapy (HRT) to ease menopause symptoms like hot flashes and night sweats may be no more likely to die prematurely than women who don’t take hormones, a new study suggests.

      Many women have been reluctant to use hormones for menopause symptoms since 2002, when the federally funded Women’s Health Initiative (WHI) study linked the treatments containing man-made versions of the female hormones estrogen and progestin to an increased risk of breast cancer, heart attacks and strokes.

      The current study, however, looked at longer-term data from the WHI study and found no increased risk of death from all causes, or from cancer or cardiovascular issues in particular, associated with hormone use.

      “Women seeking treatment for distressing hot flashes, night sweats or other menopausal symptoms may find the mortality results reassuring,” said lead study author Dr. JoAnn Manson of Brigham and Women’s Hospital and Harvard Medical School in Boston.

      Source
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      Administration of daily 5 mg tadalafil improves endothelial function in patients with benign prostatic hyperplasia.


      Tadalafil is a promising phosphodiesterase (PDE) 5 inhibitor prescribed for erectile dysfunction (ED). Daily low dose (5 mg) of tadalafil has also been used for the treatment of male lower urinary tract symptoms (LUTS) associated with benign prostate hyperplasia (BPH). PDE5 inhibitors induce relaxation of smooth muscle cells in the urethra, prostate, bladder neck, and blood vessels. The aim of this study was to investigate the efficacy of tadalafil on vessels endothelial function, in patients with male LUTS symptoms associated with BPH.

      The Institutional Review Board (IRB) approved this clinical study and informed consents had been obtained from 81 BPH patients. The following male LUTS parameters: international prostate symptom score (IPSS), overactive bladder symptom score (OABSS), voiding volume, max and mean voiding flow on voiding flowmetry examination and post-voiding residual urine (RU) were compared at 0, 1, 3, 6, and 12 months after a daily dose of 5 mg tadalafil. In addition, erectile function was evaluated by the sexual health inventory for men (SHIM) score and vessels endothelial function and peripheral neuropathy were assessed by the brachial-ankle pulse wave velocity (baPWV), ankle brachial index (ABI), and vibration perception threshold (VPT) at 0, 3, 6, and 12 months after treatment.
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      Visceral adiposity index is associated with benign prostatic enlargement in non-diabetic patients: a cross-sectional study.

      To evaluate the association between visceral adiposity index (VAI) - a novel indicator for the assessment of visceral adipose tissue and prostate enlargement in non diabetic patients.

      Four hundred patients who were admitted to the Urology clinic between January and December 2014 with complaints of BPH(benign prostatic hyperplasia )/LUTS(male lower urinary tract symptoms)were enrolled in this cross-sectional study. Patients were divided into two groups according to their prostate volume and international prostate symptom score (IPSS) value. They were compared in terms of age, body mass index (BMI), VAI, prostate volume, PSA, post micturional residual volume (PMRV), uroflowmetry Q max value, triglyceride (TG), high density lipoprotein-cholesterol (HDL-C) and fasting blood sugar (FBS).

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    • You have probably reached our site in your search for health and potency. Are you wondering who to trust with men’s health information in an online world full of scammers and deception? Well, you are in the right place!

      Welcome to ExcelMale.com, one of the largest and best moderated men’s health forums on the Internet focused on increasing health, potency and productivity in men. With over 13,000 members (as of April 2016) that include educated men, physicians, pharmacists, dietitians, exercise trainers, nutritional supplement experts, and other professionals in the field, ExcelMale is fast becoming a leader in the field. Our forum topics range from testosterone replacement therapy, Trimix injections use for ED, HCG use for better fertility and libido, estradiol management, thyroid function optimization, peptide information, exercise routines, best supplements for men, high protein diets, testosterone side effect management and much more. We also provide men’s health information via Interviews with experts, Videos, and webinars. Last but not least, our members share their reviews of hormone replacement clinics and doctors, compounding pharmacies, pharmaceutical products, supplements, and much more. Our great moderators review every post daily to detect spammers or abuse, so ExcelMale is a safe environment for all men. And since every man wants to help important women in their lives, we do not neglect female health information as we include a folder called “ExcelFemale” to post the latest on HRT in women.


      Search our content by typing your question here.

      Register here to join our community! Don’t be shy, ask questions by posting in any forum folder. We can help each other to regain our best selves!.


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