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      Please reserve your spot by using this link: http://bit.ly/clinicoptimizersgh

      Growth hormone secretagogues (GSHs) are a class of drugs which act as secretagogues (i.e., induce the secretion) of growth hormone (GH). They include agonists of the ghrelin/growth hormone secretagogue receptor (GHSR), such as ghrelin (lenomorelin), pralmorelin (GHRP-2), GHRP-6, examorelin (hexarelin), ipamorelin, and ibutamoren (MK-677), and agonists of the growth hormone-releasing hormone receptor (GHRHR), such as growth hormone-releasing hormone (GHRH) (somatorelin), CJC-1295, sermorelin, and tesamorelin. Many also induce the secretion of insulin-like growth factor 1 (IGF-1), as well as of other hypothalamic-pituitary hormones such as prolactin and cortisol. ...
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      Article Preview It's a mouse study - the point is acknowledged. However, new research at MIT raises some intriguing issues.

      As people age, their intestinal stem cells begin to lose their ability to regenerate. These stem cells are the source for all new intestinal cells, so this decline can make it more difficult to recover from gastrointestinal infections or other conditions that affect the intestine. This age-related loss of stem cell function can be reversed by a 24-hour fast, according to a new study from MIT biologists. The researchers found that fasting dramatically improves stem cells’ ability to regenerate, in both aged and young mice.

      In fasting mice, cells begin breaking down fatty acids instead of glucose, a change that stimulates the stem cells to become more regenerative. The researchers found that they could also boost regeneration with a molecule that activates the same metabolic switch. Such an intervention could potentially help older people recovering from GI infections or cancer patients undergoing chemotherapy, the researchers say.
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      More evidence higher hormone levels are heart healthy. The abstract says:

      The cardiovascular effects of testosterone and dihydrotestosterone are generally attributed to their modulatory action on lipid and glucose metabolism. However, no ex vivo studies suggest that circulating androgen levels influence the activation and reactivity of blood platelets - one of the main components of the haemostasis system directly involved in atherosclerosis. The levels of testosterone, dihydrotestosterone and oestradiol in plasma from men and women aged from 60 to 65 years were measured by LC-MS; the aim was to identify any potential relationships between sex steroid levels and the markers of platelet activation. The results of the ex vivo part of the study indicate that the concentrations of testosterone and its reduced form, dihydrotestosterone are significantly negatively associated with platelet activation and reactivity.
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      Endocr Connect. 2017 Aug 9;6(7):430-436. doi: 10.1530/EC-17-0159. Print 2017 Oct.

      HIIT produces increases in muscle power and free testosterone in male masters athletes

      Herbert P1, Hayes LD2, Sculthorpe NF3, Grace FM4.

      Abstract

      High-intensity interval training (HIIT) improves peak power output (PPO) in sedentary aging men but has not been examined in masters endurance athletes. Therefore, we investigated whether a six-week program of low-volume HIIT would (i) improve PPO in masters athletes and (ii) whether any change in PPO would be associated with steroid hormone perturbations. Seventeen male masters athletes (60 ± 5 years) completed the intervention, which comprised nine HIIT sessions over six weeks. HIIT sessions involved six 30-s sprints at 40% PPO, interspersed with 3 min active recovery. ...
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      Roli L, et al. J Endocrinol Invest. 2017.

      The steroid response to human chorionic gonadotropin (hCG) stimulation in men with Klinefelter syndrome does not change using immunoassay or mass spectrometry.

      Abstract

      PURPOSE: Liquid-chromatography tandem mass-spectrometry (LC-MS/MS) was developed in parallel to Immunoassays (IAs) and today is proposed as the "gold standard" for steroid assays. Leydig cells of men with Klinefelter syndrome (KS) are able to respond to human chorionic gonadotropin (hCG) stimulation, even if testosterone (T) production was impaired. The aim was to evaluate how results obtained by IAs and LC-MS/MS can differently impact on the outcome of a clinical research on gonadal steroidogenesis after hCG stimulation.

      METHODS: A longitudinal, prospective, case-control clinical trial. (clinicaltrial.gov NCT02788136) was carried out, enrolling KS men and healthy age-matched controls, stimulated by hCG administration. Serum steroids were evaluated at baseline and for 5 days after intramuscular injection of 5000 IU hCG using both IAs and LC-MS/MS. ...
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      We're talking anabolic doses, 10 or 20 mg/kg, which is 800 mg or 1600 mg for the average weight man. It looks like the toxic effects of trans fats are increased by testosterone. The abstract says:

      We investigated the impact of AS on gene expression, lipid profile, redox status and the development of nonalcoholic fatty liver disease (NAFLD) in mice treated with a diet rich in trans fatty acids. Seventy-two mice were equally randomized into six groups and treated with a standard diet (SD) or high-fat diet (HFD) alone or combined with testosterone cypionate (10 or 20 mg/kg) for 12 weeks. When combined with a HFD, AS reduced plasma HDL cholesterol levels. It also upregulated SREBP-1, PPARα, SCD-1 and ACOX1 gene expression; plasma and hepatic triglyceride levels; oxidative stress; circulating hepatic transaminase levels and NAFLD severity.
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      The standard predictor of cardiovascular disease (CVD) risk is the Framingham Risk Score. The Framingham Score predicts the 10 year risk of heart disease and is based on age, smoking, total cholesterol, HDL cholesterol, and blood pressure. This study added testosterone levels to the Framingham Score and found that it did not improve the prediction of heart disease. The abstract says:

      Among 816 men, 30-70 years/old, without prevalent CVD, from a community-based cohort (Tehran Lipid and Glucose Study), we assessed the predictive value of testosterone with incident CVD, using three multivariate Cox proportional-hazards models. Model I: FRS variables; model II: Model I plus total testosterone; model III: Model II plus Systolic blood pressure (SBP) * total testosterone (the best fit interaction-term between testosterone and FRS variables). During 12 years of follow-up, 121 CVD events occurred.
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      Excellent article to read if you know anyone thinking about using any of these clinics.

      "The treatments are not covered by insurance. Many of the clinics’ patients are old, sick and already struggling with medical bills. Some clinics urge individuals who can’t afford their steep fees — which range from $1,800 to more than $20,000 — to launch GoFundMe pages or take out loans, according to patients and former employees."

      "Stem cell clinics have exploded in number across the United States. In 2009, there were two; today, there are at least 700 and likely hundreds more, according to Leigh Turner, a University of Minnesota bioethicist, and Paul Knoepfler, a stem cell biologist at the University of California at Davis, who have compiled a database. In the past four years, at least 150 new facilities have opened every year." ...
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      [PDF] MP85-13 ERECTILE FUNCTION IN 478 HYPOGONADAL MEN WITH MODERATE TO SEVERE ED WITH AND WITHOUT TESTOSTERONE THERAPY FOR UP TO …

      A Haider, KS Haider, G Doros, A Traish - The Journal of Urology, 2018
      METHODS 478 men with testosterone≤ 350 ng/dL and hypogonadal symptoms had
      moderate to severe ED according to IIEF-EF (5+ 1, maximum score: 30). 246
      received testosterone undecanoate injections (TU) 1000 mg/12 weeks following an …



      [PDF] MP85-15 TESTOSTERONE TREATMENT IN MEN WITH CLASSICAL VS FUNCTIONAL HYPOGONADISM: RESULTS FROM A 9-YEAR-REGISTRY

      M Zitzmann, E Nieschlag, A Traish, S Kliesch - The Journal of Urology, 2018
      METHODS Registry data of max. 9 years comprising 650 patients with
      hypogonadism including 266 men with primary (mean age 34.0±11.7 years), 196
      with secondary (mean age 31.9±12.0 years) and 188 with functional hypogonadism …


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      Earlier this week, Senators Orrin Hatch (R-UT) and Sheldon Whitehouse (D-RI) introduced the SARMs Control Act of 2018. If passed and signed by the President, the Act would amend the Controlled Substances Act to list SARMs as Schedule III controlled substances, meaning they would be regulated by the DEA the same as anabolic steroids.
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      https://www.govtrack.us/congress/bil...utm_medium=rss
      .
      https://www.hatch.senate.gov/public/...ation-of-sarms
      .
      The Act defines "SARM" as "any drug or other substance that is a selective androgen receptor agonist chemically unrelated to tesosterone, estrogens, progestins, corticosteroids, and dehydroepiandrosterone . . ." Specifically scheduled (but not an exclusive list if the substance otherwise fits the definitions) are ostarine, LGD-4033 (ligandrol), RAD-140, andarine, and several other common SARMs products. ...
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      An article recommends treating obese men with hypogonadism for obesity first.

      Obesity, increasing in prevalence globally, is the clinical condition most strongly associated with lowered testosterone concentrations in men, and presents as one of the strongest predictors of receiving testosterone treatment. While low circulating total testosterone concentrations in modest obesity primarily reflect reduced concentrations of sex hormone binding globulin, more marked obesity can lead to genuine hypothalamic-pituitary-testicular axis (HPT) suppression. Although the obesity-hypogonadism relationship is bi-directional, the effects of obesity on testosterone concentrations are more substantial than the effects of testosterone on adiposity. In markedly obese men submitted to bariatric surgery, substantial weight loss is very effective in reactivating the HPT axis.
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