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      GettingAnswers, you have done excellent troubleshooting by trying both Testosterone Cypionate and Testosterone Enanthate to narrow down why you are having a local reaction to these medications. You are also correct that it's impossible to create a "jet" of oil with a syringe due to the fact that the liquid is too viscous and the needle bore too small to create a sufficient flow rate.

      Any one of the ingredients in Testosterone Cypionate, which include Cottonseed Oil (carrier oil), Benzyl Benzoate (solubilizer), or Benzyl Alcohol (preservative) might cause the reaction. Since you already tried Testosterone Enanthate, which uses a different carrier oil (Sesame Oil) and preservative (Chlorobutanol) and still had the same local reaction I would say that it's not the carrier oil, solubilizer, or preservative that is causing it. It's doubtful that changing the oil is going to make any difference. Your body just doesn't like subcutaneous injections of oil-based testosterone. This is a common side effect for patients doing SQ injections of testosterone. ...
      by
      Hi Vince. My name is Jasen and I have worked in a compounding pharmacy and have worked with compounders for roughly 8 years. Most manufactured testosterone injectables are suspended in cottonseed or sometimes sesame seed oil. Both of these oils are sterilized and pass USP standards, but they are indeed "cheaper" oils typically used in mass-produced testosterone. Compounding pharmacies can use any oil you and your physician requests, like grapeseed and sesame oils. The amount of the oil injected should not be a concern as it is such as small amount, which the body will metabolize, and it is sterilized of impurities. Unless you are allergic to the oil itself than I would not be concerned at all. If you are allergic to cottonseed than you will want to choose another oil to avoid a reaction.

      Although you did not ask about the difference between testosterone enanthate and cypionate, here is a link which discusses the different testosterone esters: http://defymedical.com/resources/hea...sterone-esters
      ...
      by
      It is interesting to see for the first time that some men do not have increases in estradiol after a shot of testosterone. 9 out of 21 were in this group. They are also the ones with lower T peak values.

      I have not read the whole paper to see what estradiol test they used and if there is something in those 9 men that differentiates them from the rest at baseline.

      Effect of a single injection of testosterone enanthate on 17β estradiol and bone turnover markers in hypogonadal male patients.

      Camozzi V, et al
      J Endocrinol Invest. 2014 Oct 16.
      ...
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      This is an example of just one protocol, since there really is no "one way" to do it. This has proven a very effective foundational protocol for Defy, but of course every patient is different and therefore treatments are individualized as needed.


      TRT: EndogenousRestoration protocol for Men Discontinuing TRT



      Male patients who have been taking any form of exogenous Testosterone long term, longer than 12 weeks, will have secondary hypogonadism induced by the negative feedback response to the exogenous T use. The purpose of this protocol is to stimulate the testes using HCG so that they are able to produce testosterone once again, while also preparing them to respond to endogenous LH/FSH(gonadotropins). Tamoxifen is taken beyond the HCG as it is shown, as a SERM, to stimulate the pituitaries release of LH/FSH whole suppressing the negative effects of excess estradiol. Estradiol can elevate in men who discontinueTRT so it is important to run the SERM for some time after discontinuingTRT to mitigate E2 rebound. ...
      by
      Testosterone propionate is definitely not for everyone, however, there are certain men who do benefit from including the ester in their therapy. Propionate needs to be injected more frequently than cypionate, roughly every 2-3 days if used as a monotherapy to keep serum testosterone stable. For this reason and due to its more robust peak (and trough) effect I personally dont favor propionate as a monotherapy, but it does appear to have anecdotal benefit when combined with a longer ester including cypionate. Some men benefit from a more robust androgen peak, perhaps those suffering from finsateride syndrome or who have trouble with downstream testosterone conversion. Others who do not metabolize the cypionate ester consistently might also benefit from including lower dosages of shortened ester for faster onset and peak before leveling out. Again, this is all anecdotal, but it appears that the different effects noticed with a cypionate/propionate blend are experienced with twice per week injections (q3days).
      ...
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      Compounded injectable testosterone medications like cypionate are presently being pushed out of the market.

      Compounding pharmacies provide a low cost alternative to standard and more expensive manufactured brand name medications. In the case of testosterone, compounding pharmacies are able to obtain the FDA approved raw material to compound testosterone into strengths, solutions, forms, and combinations not available on the market. Testosterone Cypionate is not under a patent, and is available as a raw material to be compounded as a sterile injectable in various custom strengths.

      Technically, a compounding pharmacy is not supposed to compound a drug in the same strength and form already available as a brand name.
      Since Testosterone Cypionate is available as a brand name (Pfizer, Watson, etc) in 10ml 200mg/ml form, many compounders alter the finished product to justify compounding it. For example they may offer it in a different strength, volume, or as a combination drug.
      ...
      by
      Hi all,

      I'm about to start TRT with Androgel 1.62% and was prescribed HCG 2x/week at 500 IU each dose to maintain fertility. Is this enough? The sticky mentions a study done by a doctor in Houston that prescribed 500 IU every other day.

      Also would there be any difference in taking the 1,000 IU weekly total spread over 2, 3, or 4x/week? I just saw a thread where someone mentioned HCG caused some issues for them and upon stopping they felt better. I'm guessing this has to do with the slight uptick in E2?? If so would spreading the dosage out help? Given I'm in my early 30s and want to retain my fertility I'd like to find an optimum balance.

      Also just curious as to what people are paying for HCG want to get an appropriate benchmark ...
      by
      An article in the International Journal of Drug Policy reports AAS users are performing self-phlebotomies. The abstract says:

      New evidence with regard to a previously undocumented practice – self phlebotomy, known as ‘bloodletting’ – in contemporary injecting performance and image enhancing drug (PIED) culture is the subject of this paper. While self phlebotomy has been evidenced in psychiatric patients previously, it was performed here in people who inject AAS as a self directed health care procedure. Data was collected from five publicly accessible internet discussion forums and coded using NVivo software. For the purposes of this study, posts in relation to bloodletting were extracted from the final set of records for analysis.

      ...
      by
      From the referenced content below which states these factors affect your testosterone levels, I was greatly violating most of them. Is it possible I should have fixed these before starting TRT? i wonder how much of an impact these could really have. how much can these factors affect someone? i have been on TRT for 8 months and am wondering if I should stop now and see where my base is since I've corrected all of the below now (i already started tapering 2 weeks)

      Summary:

      1) Drink water from glass or stainless steel and avoid plastic Tupperware.
      2) Avoid soy like the plague.
      3) Limit your alcohol consumption.
      4) Drink vodka on special occasions instead of beer.
      5) Sleep eight hours at night in a dark room.
      6) Eliminate stress when possible. Meditate, practice yoga, laugh and
      hang out with people who make you happy.
      7) Decrease your body fat.
      8) Eat foods rich in zinc.
      9) Eat healthy fats from the sources listed above
      10) Think about sex and openly discuss any issues with your partner.
      ...
      by
      Article Preview
      • Currently, only topical minoxidil (MNX) and oral finasteride (FNS) are approved by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of androgenetic alopecia.
      • Although FNS is efficacious for hair regrowth, its systemic use is associated with side effects limiting long-term utilization. Exploring topical FNS as an alternative treatment regimen may prove promising.
      • In its systemic form, various side effects such as gynecomastia, breast tenderness, malignant neoplasms of the male breast, decreased ejaculate volume, a decrease in testicular size, testicular pain, reduction in penile curvature, reduction in penile size, sexual disorder, male infertility, high-grade prostate cancer, and prostatitis have been reported.
      ...
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      Article Preview One of the most frequent, unwanted side-effect for men on TRT is the rise in hematocrit levels. A recent study of trans men highlighted the issue.



      • In trans persons on gender-affirming hormonal treatment, a decrease (in trans women) or increase (in trans men) in hematocrit is often observed.
      • 625 hormone-naïve trans persons were enrolled in the study.
      • Gender-affirming hormonal treatment was initiated at the first visit.
      • In trans men, serum hematocrit (Hct) levels increased during the first year (+4.9 Hct %, 95% CI 3.82-5.25), with the most pronounced increase during the first 3 months (+2.7 Hct %, 95% CI 1.94-3.29).
      ...
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      Article Preview A frequent cause of high blood pressure and water retention is when levels of certain hormones in the body are unbalanced or functioning poorly. The hormones that are frequently at fault are secreted by the kidneys and the pituitary or adrenal glands. They are called aldosterone, ACTH, and renin


      What is aldosterone?

      Aldosterone (ALD) is one of a group of connected hormones. They form the renin–angiotensin–aldosterone system (1); this system is activated when there is a decrease in blood flow to your kidneys following a drop in blood volume or blood pressure such as during heavy bleeding, or sodium levels fall below healthy levels (1).
      ...

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      Welcome to ExcelMale.com, one of the largest and best moderated men’s health forums on the Internet focused on increasing health, potency and productivity in men. With over 13,000 members (as of April 2016) that include educated men, physicians, pharmacists, dietitians, exercise trainers, nutritional supplement experts, and other professionals in the field, ExcelMale is fast becoming a leader in the field. Our forum topics range from testosterone replacement therapy, Trimix injections use for ED, HCG use for better fertility and libido, estradiol management, thyroid function optimization, peptide information, exercise routines, best supplements for men, high protein diets, testosterone side effect management and much more. We also provide men’s health information via Interviews with experts, Videos, and webinars. Last but not least, our members share their reviews of hormone replacement clinics and doctors, compounding pharmacies, pharmaceutical products, supplements, and much more. Our great moderators review every post daily to detect spammers or abuse, so ExcelMale is a safe environment for all men. And since every man wants to help important women in their lives, we do not neglect female health information as we include a folder called “ExcelFemale” to post the latest on HRT in women.


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