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      A new meta-analysis looks at the studies on fat free mass and strength gains from TRT and finds a difference in results depending on how it is administered. Intramuscular injection was 3-5 times more effective than transdermal application in increasing fat free mass (FFM) and strength.

      When administration routes were collectively assessed, TRT was associated with increases in FFM, total body strength, lower-extremity strength, and upper-extremity strength. When administration routes were evaluated separately, the magnitudes were larger and the per cent changes were 3–5 times greater for intramuscular TRT than for transdermal formulations vs. respective placebos, for all outcomes evaluated.
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      As we learn more about how elevated levels of Lp(a) can potentially kill us before anyone can determine the cause, it is imperative that everyone get this lipid marker tested frequently, especially those on any type of HRT regimen. It is entirely possible that one of the leading culprits behind the upsurge of recent untimely deaths we've been seeing pop up left and right in the sports and bodybuilding community, in which "enhanced" athletes are pushing beyond human limits, could very well be unchecked elevated Lp(a) levels.

      Standard lipid panels are pretty much worthless for many reasons, one being that Lp(a) levels are never included. Thus, millions go unchecked that potentially could have avoided that MI (heart attack) or TIA (stroke), etc. had they known they were at risk.
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      Association Between Testosterone Replacement Therapy and the Incidence of DVT and Pulmonary Embolism: A Retrospective Cohort Study of the Veterans Administration Database.

      Sharma R, et al. Chest. 2016.

      Abstract
      BACKGROUND: Testosterone replacement therapy (TRT) prescriptions have increased several-fold in the last decade. There have been concerns regarding a possible increased incidence of DVT and pulmonary embolism (PE) with TRT. Few data support the association between TRT and DVT/PE. We evaluated the incidence of DVT and PE in men who were prescribed TRT for low serum total testosterone (sTT) levels.

      METHODS: This is a retrospective cohort study, conducted using data obtained from the Veterans Affairs Informatics and Computing Infrastructure. We compared the incidence of DVT/PE between those who received TRT and subsequently had normal on-treatment sTT levels (Gp1), those who received TRT but continued to have low on-treatment sTT (Gp2), and those who did not receive TRT (Gp3). Those with prior history of DVT/PE, cancer, hypercoagulable state, and chronic anticoagulation were excluded. ...
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      Article Preview The study was a 2 x 2 factorial design where older men were given 100 mg of testosterone a week or not and were eating 1.3 g/kg or 0.8 g/kg (the RDA) of protein a day. No mention is made in the summary of any exercise program, but the summary says the men were "functionally limited." The men were followed for 6 months. As you can see from the graph, testosterone significantly increased lean body mass, but there was no benefit from additional protein.

      This randomized clinical trial with a 2 × 2 factorial design was conducted in a research center. A modified intent-to-treat analytic strategy was used. Participants were 92 functionally limited men 65 years or older with usual protein intake less than or equal to 0.83 g/kg/d within the RDA.
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      Article Preview

      Adrenal fatigue is a collection of signs and symptoms called a functional somatic syndrome where there are imbalances that cause the reserve present in the adrenal gland to be depleted below the necessary level. When evaluating healthy adults, some studies have found that 40 percent of people 60 years of age or older may present with what is called stage 3 adrenal deficiency and depression.

      Overall , adrenal fatigue is going to affect most people during the course of their lifetime. Signs and symptoms include feeling tired, run down, difficulty getting up, feeling depleted in the morning and feeling more energetic at the end of the day. Many people use caffeine as an antidote to help to deal with this problem.
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      Article Preview




      " There are various hormones in our bodies, and many of them are made in the adrenal glands. One of them, specifically, is pregnenolone, and it is the one from which all the other adrenal hormones are made - about 150 of them.We've heard of estrogen and testosterone. We've heard ...
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      Article Preview


      Estradiol is a very important sex hormone--in fact, it's the primary female sex hormone. It plays a central role in female reproductive health, as it promotes the development and maintenance of the ovaries, eggs, and other reproductive tissues.
      The male body does produce some estradiol, though in much lower quantities than the female body, via the actions of the aromatase enzyme that converts some testosterone into estradiol. Excess or too little estradiol can have health consequences in men. These are a few of them:

      It Can Cause "Man Boobs"

      Men who develop "man boobs" suffer from gynecomastia, a condition where their glandular breast tissues are enlarged. The condition is the result of the body converting too much testosterone into estradiol, which in turn causes growth in glandular tissue. Testosterone replacement therapy can increase the risk of gynecomastia, particularly in men with high levels of the enzyme aromatase. This problem can be prevented with the use of an estradiol blocker (aromatase inhibitor) like anastrozole, but the dosage has to be adequate to avoid low estradiol.

      It Plays a Role on Fat Mass ...
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      ALRIGHT MY FRIENDS HERE'S SOME KNOWLEDGE THAT WILL CHANGE LIVES ON TRT FOREVER

      -Originally wrote this as a reply to someone on a different thread, but decided to put it in it's own thread as well.-

      This is how half lives work. For example,
      let's say you take 1mg of Arimidex EOD. The
      half-life of Arimidex is 2 days. So in 2 days when you take another dose, you still have 50% of the previous dose in your system. So if you took 1mg Monday, then took 1mg Wednesday, you have 1mg from Wednesday's dose, plus 0.5mg from Monday's dose. So 1.5mg total in your system. Then you take another 1mg Friday. You now have 1mg from Friday's dose, 0.5mg from Wednesday, and 0.25mg from Monday's dose. So on Friday, you have 1.75mg on your system. Then on Sunday, you will have 1mg from Sunday's dose, 0.5mg from Friday, 0.25mg from Wednesday and 0.125mg from Monday's dose. So 1.875mg in your system on Sunday. So on Tuesday, you will have 1mg from Tuesday, 0.5mg from Sunday, 0.25mg from Friday, 0.125mg from Wednesday, and 0.0625mg from Monday. So in total on Tuesday you will have 1.9375mg in your system. So do this math one more time for Thursday's dose. Which will equal 1.96875mg, basically 2mg in your system on the 10th day. On the 10th day you have now reached a "steady state" of this medication. This means from the 10th day on if you keep taking 1mg of Arimidex EOD, you will always have roughly 2mg in your system at all times. The amount of milligrams in your system does not continue going up from this point. ...
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      Article Preview In this video the folks from Defy Medical show how to safely inject testosterone in the glutes.



      The following information was taken from the book: Testosterone: A Man's Guide

      How to Inject Testosterone Safely

      Some men prefer testosterone injections because of the convenient dosing and/or they report feeling much better when using injections versus gels. Sometimes their insurance companies only pay for injections. Men without health insurance also tend to use injections since they are a lot cheaper than gels. If your doctor empowers you to self-inject at home, it will be more convenient and possible cheaper (some physicians charge for the office visit). I tell men that they can always switch from gels to injections and vice versa depending on what they learn as they optimize their testosterone replacement.
      So you’ve decided to go with injectable testosterone. Your decision may arise out of your realization that you won’t remember to make daily use of the gels. It may have made the choice because your insurance company refuses to pay for anything but the injectable. If your doctor is letting you self-inject there are some things for you to know:
      ...
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      Article Preview Who is a Candidate for Testosterone Replacement Therapy?

      By Abraham Morgentaler, M.D.
      There is consensus that candidates for treatment with Testosterone Replacement Therapy should have signs or symptoms of TESTOSTERONE DEFICIENCY combined with biochemical evidence of low T levels.13 The challenge, however, is deciding what T level is considered low. For the first 40 years after the commercial availability of T products, the diagnosis was made entirely on clinical presentation. With the introduction of readily available testing with the development of radioimmunoassays in the 1970s, the emphasis shifted to documentation of low blood levels. Today, it is becoming increasingly clear that symptoms and clinical presentation should once again take priority,13 with blood test results an important, yet secondary confirmation. ...

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    • You have probably reached our site in your search for health and potency. Are you wondering who to trust with men’s health information in an online world full of scammers and deception? Well, you are in the right place!

      Welcome to ExcelMale.com, one of the largest and best moderated men’s health forums on the Internet focused on increasing health, potency and productivity in men. With over 13,000 members (as of April 2016) that include educated men, physicians, pharmacists, dietitians, exercise trainers, nutritional supplement experts, and other professionals in the field, ExcelMale is fast becoming a leader in the field. Our forum topics range from testosterone replacement therapy, Trimix injections use for ED, HCG use for better fertility and libido, estradiol management, thyroid function optimization, peptide information, exercise routines, best supplements for men, high protein diets, testosterone side effect management and much more. We also provide men’s health information via Interviews with experts, Videos, and webinars. Last but not least, our members share their reviews of hormone replacement clinics and doctors, compounding pharmacies, pharmaceutical products, supplements, and much more. Our great moderators review every post daily to detect spammers or abuse, so ExcelMale is a safe environment for all men. And since every man wants to help important women in their lives, we do not neglect female health information as we include a folder called “ExcelFemale” to post the latest on HRT in women.


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      Register here to join our community! Don’t be shy, ask questions by posting in any forum folder. We can help each other to regain our best selves!.


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