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      Let's try to clear up some confusion here. No need to debate what the E2 level in a young male going through puberty would be but yes it can run >70. This is not the point. The point is that a level ...
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      Exp Clin Endocrinol Diabetes 2015; 123(10): 608-613

      The Effect of Metformin and Metformin-Testosterone Combination on Cardiometabolic Risk Factors in Men with Late-onset Hypogonadism and Impaired Glucose Tolerance

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      “The novelty in our study stems from the fact that we simultaneously investigated the effects of testosterone in the context of a rigorous weight-loss program,” Mathis Grossmann, MD, PhD,FRACP, professor in the department of medicine ...
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      Article Preview


      Phthalates are used in a large variety of products, from enteric coatings of pharmaceutical tablets and nutritional supplements to viscosity control agents, gelling agents, film formers, stabilizers,dispersants, lubricants, binders, emulsifying agents, and suspending agents. End-applications include adhesives ...
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      Article Preview The best paper to date summarizing research therapies for ED. I highly recommend reading the full paper below (attached file- Register on ExcelMale to open it).



      Abstract: Although oral phosphodiesterase-5 (PDE5) inhibitors are generally ...
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      Article Preview
      I get a lot of emails from men on testosterone replacement therapy (and/or HCG) that feel they have water retention (some with ankle swelling) and they are puzzled that their estradiol is low or below 35 micrograms/ml. They may have tried anastrozole treatment without any success in decreasing water retention.

      This study was pointed out by a previous article written by Patrick Arnold.

      "There is an enzyme that is localized primarily in the kidneys whose function is to protect the kidneys from circulating cortisol. The kidneys have receptors called mineralcorticoid receptors (MR’s) which are meant to bind to specific adrenal hormones (called mineralcorticoids) in the body such as aldosterone. The result of this binding is a signal to increase sodium and water retention in the body, while stimulating the excretion of potassium. This is an important mechanism to maintain fluid and electrolyte balance in the body.
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      Association Between Testosterone Replacement Therapy and the Incidence of DVT and Pulmonary Embolism: A Retrospective Cohort Study of the Veterans Administration Database.

      Sharma R, et al. Chest. 2016.

      Abstract
      BACKGROUND: Testosterone replacement therapy (TRT) prescriptions have increased several-fold in the last decade. There have been concerns regarding a possible increased incidence of DVT and pulmonary embolism (PE) with TRT. Few data support the association between TRT and DVT/PE. We evaluated the incidence of DVT and PE in men who were prescribed TRT for low serum total testosterone (sTT) levels.

      METHODS: This is a retrospective cohort study, conducted using data obtained from the Veterans Affairs Informatics and Computing Infrastructure. We compared the incidence of DVT/PE between those who received TRT and subsequently had normal on-treatment sTT levels (Gp1), those who received TRT but continued to have low on-treatment sTT (Gp2), and those who did not receive TRT (Gp3). Those with prior history of DVT/PE, cancer, hypercoagulable state, and chronic anticoagulation were excluded.
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      Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial.

      Ng Tang Fui M, et al. BMC Med. 2016.

      Abstract
      BACKGROUND: Whether testosterone treatment has benefits on body composition over and above caloric restriction in men is unknown. We hypothesised that testosterone treatment augments diet-induced loss of fat mass and prevents loss of muscle mass.

      METHODS: We conducted a randomised double-blind, parallel, placebo controlled trial at a tertiary referral centre. A total of 100 obese men (body mass index ≥ 30 kg/m(2)) with a total testosterone level of or below 12 nmol/L and a median age of 53 years (interquartile range 47-60) receiving 10 weeks of a very low energy diet (VLED) followed by 46 weeks of weight maintenance were randomly assigned at baseline to 56 weeks of 10-weekly intramuscular testosterone undecanoate (n = 49, cases) or matching placebo (n = 51, controls). The main outcome measures were the between-group difference in fat and lean mass by dual-energy X-ray absorptiometry, and visceral fat area (computed tomography).
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      Article Preview DHT – FRIEND OR ENEMY?

      With the exception of estradiol, no hormone is more misunderstood than dihydrotestosterone, DHT. In fact, many men actually fear DHT, going out of their way to lower it and frustrate its biological activity. However, DHT is actually a critical hormone, one that men need for sexual and prostate health, cognitive function, skeletal strength – and many other reasons. Like everything in life, there are downsides to DHT, but the upside of healthy DHT levels far outweighs the challenges it can present.



      DHT – Where it Comes From

      The principal hormone produced in men is, of course, testosterone. When testosterone is produced by the testicles (or injected/absorbed by a man on testosterone replacement) an enzyme, 5-alphareductase (5-AR) sets to work converting a portion of that testosterone to DHT. ...
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      Article Preview Although the measurement of serum testosterone levels is commonly used in the diagnosis of male HG, the cut-off values for low testosterone are not well defined and vary throughout the literature, ranging from 200–400 ng/dL, with 300 ng/dL being the most commonly utilized in clinical practice. Other measurements such as FT may also be used. Although cut-off is an important component in diagnosing HG, guidelines from the United States Endocrine Society define HG as symptoms of HG with TT <300 ng/dL, which differs from the cut-off of 249 ng/dL recommended by the European Association for Urology (10,26).


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      I could not see clomid dosages used.


      This makes a big difference, as we now no too much zuclomiphene causes inverse effects. According to Dr Saya, this does not seem to happen in the low dose patients they see, which appears to be consistent with other doctors now using lower dose clomid.


      Too bad enclomiphene is being held up, at least last I heard. This is an important tool for diagnosing younger men and/or boosting borderline TT levels that don't warrant full replacement.


      Either way, nothing works as good as testosterone supplementation since you get a guaranteed bell curve of androgens after administration.

      _______________________________________

      Testosterone versus clomiphene citrate in managing symptoms of hypogonadism in men

      Pranav Dadhich1, Ranjith Ramasamy2, Jason Scovell1, Nathan Wilken1, Larry Lipshultz1
      1 Scott Department of Urology, Baylor College of Medicine, Houston, USA
      2 Department of Urology, University of Miami Miller School of Medicine, Miami, Florida, USA


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      Androgen Therapy and Rehospitalization in Older Men With Testosterone Deficiency.

      Baillargeon J, et al. Mayo Clin Proc. 2016.


      OBJECTIVE: To assess whether the receipt of androgen therapy is associated with a reduced 30-day rehospitalization rate among older men with testosterone deficiency.

      PATIENTS AND METHODS: We conducted a retrospective cohort study using a 5% national sample of Medicare beneficiaries. We identified 6372 nonsurgical hospitalizations between January 1, 2007, and December 31, 2012, for male patients aged 66 years and older with a previous diagnosis of testosterone deficiency. Patients who died or lost Medicare coverage in the 30 days after hospital discharge or who were discharged to another inpatient setting were excluded from the analysis. Logistic regression was used to calculate odds ratios (ORs) and 95% CIs for the risk of 30-day hospital readmissions associated with receipt of androgen therapy.

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    • You have probably reached our site in your search for health and potency. Are you wondering who to trust with men’s health information in an online world full of scammers and deception? Well, you are in the right place!

      Welcome to ExcelMale.com, one of the largest and best moderated men’s health forums on the Internet focused on increasing health, potency and productivity in men. With over 13,000 members (as of April 2016) that include educated men, physicians, pharmacists, dietitians, exercise trainers, nutritional supplement experts, and other professionals in the field, ExcelMale is fast becoming a leader in the field. Our forum topics range from testosterone replacement therapy, Trimix injections use for ED, HCG use for better fertility and libido, estradiol management, thyroid function optimization, peptide information, exercise routines, best supplements for men, high protein diets, testosterone side effect management and much more. We also provide men’s health information via Interviews with experts, Videos, and webinars. Last but not least, our members share their reviews of hormone replacement clinics and doctors, compounding pharmacies, pharmaceutical products, supplements, and much more. Our great moderators review every post daily to detect spammers or abuse, so ExcelMale is a safe environment for all men. And since every man wants to help important women in their lives, we do not neglect female health information as we include a folder called “ExcelFemale” to post the latest on HRT in women.


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