I've been on TRT for more than two years. Dialed in and feeling great for most of that time. I have used a low dose of adex the whole time. Seems like the general consensus on this site is to avoid adex unless you need a D cup bra or have severe swelling. Maybe I'm just sensitive to E2, but I feel awesome when my E2 is mid 20's to mid 30's. Any higher and I lose a lot of the positive effects of TRT.