Testosterone Reduces Fat by Decreasing Leptin Resistance

Nelson Vergel

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“The novelty in our study stems from the fact that we simultaneously investigated the effects of testosterone in the context of a rigorous weight-loss program,” Mathis Grossmann, MD, PhD, FRACP, professor in the department of medicine at the University of Melbourne, told Endocrine Today. “This allowed us to conclude that testosterone treatment reduces leptin over and above the effects of weight loss, suggesting testosterone reduces leptin resistance.”


“The negative effect of testosterone on other adipokines and gut hormones in the context of weight loss suggests that testosterone treatment reduces fat mass by mechanisms other than appetite, in itself an important finding,” Grossman said. “Finally, by demonstrating the persistent changes of gut hormones and adipokines after weight maintenance, we not only confirm the [prior findings], but extend their findings to a controlled setting in a larger, exclusively male population.”

http://www.healio.com/endocrinology/hormone-therapy/news/in-the-journals/%7B7e304405-3252-40f7-b8ff-777548a84af1%7D/testosterone-therapy-decreases-leptin-levels-in-men-with-obesity
 
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